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Unlocking tumor immune evasion: IL1RL1+ Treg cells and CAFs collaborate for immunotherapy resistance

Researchers demonstrated that the crosstalk between IL1RL1+ regulatory T-cells (Treg) and cancer-associated fibroblasts (CAFs) drives the tissue repairing.

30 Aug 2023

Beyond traditional models: 3D bioprinted tumor microenvironment unlocks resistance insights

Researchers developed a three-dimensional (3D) biologically printed in vitro model of the breast cancer tumor microenvironment.

28 Aug 2023

Novel microfluidic cell separation technology for early cancer detection

Early detection allows for timely intervention in many diseases before they progress to a severe stage, often at a lower treatment cost.

25 Aug 2023

Artificial intelligence and polyclonal antibody sequencing redefine the future of antibody discovery

In this interview, News-Medical had the opportunity to speak with Dr. Xiaobing Han, Principal Scientist for Antibody Discovery at Rapid Novor.

From Rapid Novor Inc 23 Aug 2023

Unleashing the Power of Microfluidic Picodroplets

In this interview conducted at SLAS EU 2023 in Brussels, Belgium, we spoke to Richard Hammond, Chief Technical Officer at Sphere Fluidics, about Sphere Fluidic's microfluidic picodroplet technology and more.

From Sphere Fluidics 21 Aug 2023

Study explores the protective effect of transmembrane mucins against SARS-CoV-2 infection

A recent study analyzed the role played by host mucins and mucin glycans with regard to SARS-CoV-2 entry into the airway epithelial cells.

15 Aug 2023

Oncolytic viruses could be used to 'warm up' cold tumors and improve immunotherapy

Equipping cancer-infecting, or oncolytic, viruses with tumor-inhibiting genetic cargo stimulates the immune system and helps immunotherapy to shrink or completely clear aggressive tumors in mice, according to a new study in the Journal of Experimental Medicine led by University of Pittsburgh and UPMC researchers.

14 Aug 2023

Unveiling hidden threats: clustering loops in CAR-T cells impact cancer therapy

How complementarity-determining region (CDR) loops in the single-chain variable fragment (scFv) influence chimeric antigen receptor (CAR)-T cell behavior.

14 Aug 2023

Newly identified helicase might hold the key to a novel family of anti-COVID-19 drugs

Researchers used a multidisciplinary approach to investigate a nonstructural protein essential in SARS-CoV-2 replication.

10 Aug 2023

Researchers discover new spiroindolin-1,2-diazepine derivatives with anti-Alzheimer therapeutic potential

In a recent study, researchers designed substituted spiro indolin-1,2-diazepine derivatives '5a–v' with cholinesterase inhibitory activities as anti-Alzheimer's disease agents.

31 Jul 2023

New technology could revolutionize treatment for age-related macular degeneration

Scientists have found a way to use nanotechnology to create a 3D 'scaffold' to grow cells from the retina –paving the way for potential new ways of treating a common cause of blindness.

28 Jul 2023

Tumor-derived GDF-15 suppresses immunotherapy response

Researchers evaluate the impact of tumor-derived GDF-15 on responses to anti-PD-1 immunotherapy.

26 Jul 2023

Meclofenamate shows promise in treating abnormal respiratory mucus

Our respiratory system is lined with a thin fluid layer called mucus on the inside. The mucus protects us from inhaling harmful and unwanted airborne agents from germs to pollutants; it achieves this feat due to its unique gel-like texture imparted by proteins called mucins.

25 Jul 2023

Study reveals potential target for repairing beta-cell dysfunction in Type 2 diabetes

Researchers used a murine model to demonstrate that functional excision of murine PITPNA eventually led to hyperglycemia in mice.

19 Jul 2023

An evaluation of the main nanotechnology approaches to improve the therapeutic potential of polyphenols against cancer

Researchers comprehensively evaluated all nanotechnology-based approaches.

18 Jul 2023

The potential prognostic role of AhRR and PPP1R3C expression in serous ovarian cancer

Study evaluated genes with copy number alterations to identify biomarkers for ovarian cancer prognosis.

18 Jul 2023

Study uncovers pathogenic variants in the chromatin modifier EZH1 as the cause of neurodevelopmental disorders

Study identified pathogenic variants in the EZH1 as a cause of neurodevelopmental disorders.

14 Jul 2023

Researchers identify glycolipid that blocks infection with SARS-CoV-2 and RSV

7DW8-5, a glycolipid that utilizes the body's non-specific immune response to quickly combat viral infections, including COVID-19 in vivo.

11 Jul 2023

Sphere Fluidics expands Cyto-Mine capabilities to meet cGMP requirements for drug manufacture workflows

Sphere Fluidics, a company developing single cell analysis systems underpinned by its patented picodroplet technology, today announced updates to its flagship platform, Cyto-Mine®, enabling it to be compliant with current Good Manufacturing Practice (cGMP) regulations enforced by the US FDA.

From Sphere Fluidics 6 Jul 2023

Researchers uncover the role of glutaminase 2 in glucose homeostasis

Glutaminase 2 (GLS2) is a master regulator of glutaminolysis. GLS2 converts glutamine to glutamate, thereby playing a role in cellular energy production. GLS2 is abundant in the liver, and is also found in pancreatic β-cells. However, the role of GLS2 in pancreatic islets – in which both ɑ- and β- cells are present – associated with glucose metabolism is currently unknown.

5 Jul 2023