Cell Metabolism News and Research

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Power-boosting signal in muscle declines with age

As people age, they may have to exercise even harder to get the benefits afforded to younger folk. That's the suggestion of a report in the February issue of the journal Cell Metabolism, showing that a signal that gives muscles a kind of metabolic boost in response to exercise is blunted in older animals.

6 Feb 2007

SH2B1 protein plays a key role in controlling body weight, response to insulin and leptin

A single protein in brain cells may act as a linchpin in the body's weight-regulating system, playing a key role in the flurry of signals that govern fat storage, sugar use, energy balance and weight, University of Michigan Medical School researchers report.

29 Jan 2007

A central thermogenic-like mechanism in feeding regulation

During periods of fasting, brain cells responsible for stimulating the appetite make sure that you stay hungry.

2 Jan 2007

Researchers uncover new way in which the aging process is linked to DNA damage

Researchers have uncovered a new way in which the aging process is linked to DNA damage--which occurs normally as a result of cell metabolism and environmental influences--and the various ways in which cells repair that damage.

23 Oct 2006

Scientists discover how brain turns on system designed to protect nerve cells from toxic "free radicals"

Scientists at Dana-Farber Cancer Institute report they have found how the brain turns on a system designed to protect its nerve cells from toxic "free radicals," a waste product of cell metabolism that has been implicated in some degenerative brain diseases, heart attacks, strokes, cancer, and aging.

20 Oct 2006

PGC-1 alpha implicated in Huntington's disease neurodegeneration

A metabolic disorder underlies the brain effects found in those with Huntington's disease, researchers report in an advance article publishing online October 19, 2006. The article will appear in the November 2006 issue of the journal Cell Metabolism, published by Cell Press.

20 Oct 2006

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

Using a combination of enzyme activity and metabolite profiling, we determined that this protein-whose function was previously unknown-serves as a key regulator of a lipid signaling network that contributes to cancer," said Benjamin F. Cravatt, a Scripps Research professor and a member of its Skaggs Institute for Chemical Biology who led the study.

20 Oct 2006

Metabolic syndrome may be treatable thanks to a newly discovered role for a regulatory gene

Single gene may contribute to the body's responses to caloric restriction and may explain some aspects of the Atkins Diet.

8 Aug 2006

Researchers discover how genes and diet interact to cause birth defects

Expectant mothers may someday get a personalized menu of foods to eat during pregnancy to complement their genetic makeup as a result of new research at Washington University School of Medicine in St. Louis.

8 Aug 2006

The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock

In mammals, including humans, a master clock in the brain and subordinate clocks found in organs throughout the body coordinate daily, or circadian, rhythms of behavior and physiology.

8 Aug 2006

Atp7a determines a hierarchy of copper metabolism essential for notochord development

A new study reveals the timing of developmental events that critically depend on copper. While copper deficiency is rare in humans, the findings suggest that suboptimal copper metabolism might contribute to birth defects, according to the researchers.

8 Aug 2006

New molecular target for obesity

Mice bred without the enzyme MKP-1 are resistant to weight gain despite consuming high fat foods and eating more than control mice, according to a research study published online in Cell Metabolism.

24 Jul 2006

Migraine with 'aura' linked to heart attacks

Researchers say that of the 28 million Americans who suffer from migraines, those who experience an "aura" before the start of the pain have an increased risk for heart attack or stroke.

19 Jul 2006

New discovery boosts basic understanding of prion infections

Brittleness is often seen as a sign of fragility. But in the case of infectious proteins called prions, brittleness makes for a tougher, more menacing pathogen.

28 Jun 2006

Gardenia fruit compound helps treat the symptoms of type 2 diabetes

A Gardenia fruit extract traditionally used in Chinese medicine to treat the symptoms of type 2 diabetes does indeed contain a chemical that reverses some of the pancreatic dysfunctions that underlie the disease, researchers report in Cell Metabolism.

6 Jun 2006

Nerve signals sent to the pancreas after eating play a critical role in blood sugar control

A critical role for b cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo.

6 Jun 2006

New study may advance treatments to prevent type 2 diabetes and metabolic syndrome

Insulin uses two distinct mechanisms to control glucose and the metabolism of blood fats (lipids) in the liver, a new Joslin Diabetes Center-led study has discovered.

23 May 2006

The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis

An imbalance in the lipid content of the liver appears to trigger the downward spiral that leads some with fatty liver disease to advance to full-blown liver failure, according to a new study in the May Cell Metabolism.

11 May 2006

Ghrelin involved in development of diabetes

Ghrelin, a hormone long considered a key player in obesity, may instead take a major role in maintaining the balance between insulin and glucose and the development of diabetes, said Baylor College of Medicine researchers in a report in the current issue of the journal Cell Metabolism.

11 May 2006

Gene "CGI-58" linked to rare disease activates fat breakdown

A gene earlier linked to a rare disease plays a critical role in the body's "finely tuned balance" of fat storage and break down, new evidence reported in the May Cell Metabolism reveals.

10 May 2006

Cell Metabolism News and Research

Power-boosting signal in muscle declines with age

SH2B1 protein plays a key role in controlling body weight, response to insulin and leptin

A central thermogenic-like mechanism in feeding regulation

Researchers uncover new way in which the aging process is linked to DNA damage

Scientists discover how brain turns on system designed to protect nerve cells from toxic "free radicals"

PGC-1 alpha implicated in Huntington's disease neurodegeneration

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

Metabolic syndrome may be treatable thanks to a newly discovered role for a regulatory gene

Researchers discover how genes and diet interact to cause birth defects

The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock

Atp7a determines a hierarchy of copper metabolism essential for notochord development

New molecular target for obesity

Migraine with 'aura' linked to heart attacks

New discovery boosts basic understanding of prion infections

Gardenia fruit compound helps treat the symptoms of type 2 diabetes

Nerve signals sent to the pancreas after eating play a critical role in blood sugar control

New study may advance treatments to prevent type 2 diabetes and metabolic syndrome

The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis

Ghrelin involved in development of diabetes

Gene "CGI-58" linked to rare disease activates fat breakdown

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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