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Experts receive $5.2 million NIH grant to develop affordable test for diagnosing Chagas disease

Experts receive $5.2 million NIH grant to develop affordable test for diagnosing Chagas disease

An international team of researchers led by infectious disease experts at the University of Georgia has received $5.2 million from the National Institutes of Health to develop a more accurate, affordable diagnostic test for Chagas disease, a parasitic infection that kills more than 50,000 people each year in Central and South America. [More]
Gene therapy may be viable approach for treating CF lung problems

Gene therapy may be viable approach for treating CF lung problems

Two new studies from the University of Iowa suggest that gene therapy may be a viable approach for treating or preventing lung disease caused by cystic fibrosis. [More]
Researchers identify mutant traits in mouse for many human disease genes

Researchers identify mutant traits in mouse for many human disease genes

About one-third of all genes in the mammalian genome are essential for life. An international, multi-institutional research collaboration identified, for the first time, mutant traits in the mouse for 52 human disease genes, which significantly contributes to the understanding of the genetic bases for some human diseases, including cardiovascular defects, spina bifida, and metabolic disorders, among many others. The study was published this week in Nature. [More]
Mitosis study identifies new potential target for cancer therapy

Mitosis study identifies new potential target for cancer therapy

Structural biologists show in a new study that an apparently key step in the process of cell division depends on a unique interaction among specific proteins, including one that is strongly linked to cancer. Their hope now is that the detailed new characterization of the interaction will make it a target for exploring a new cancer therapy. [More]
Researchers working to find faster way to treat sleeping sickness using oral drugs

Researchers working to find faster way to treat sleeping sickness using oral drugs

Researchers at the University of Georgia are working to find the fastest way possible to treat and cure human African trypanosomiasis, long referred to as sleeping sickness. By working to improve chemical entities already tested in human clinical trials, they hope to have a faster route to field studies to treat the disease using drugs that can be administered orally to patients. [More]
UC Davis scientists show how cells control DNA synthesis in mitochondria

UC Davis scientists show how cells control DNA synthesis in mitochondria

Aging, neurodegenerative disorders and metabolic disease are all linked to mitochondria, structures within our cells that generate chemical energy and maintain their own DNA. In a fundamental discovery with far-reaching implications, scientists at the University of California, Davis, now show how cells control DNA synthesis in mitochondria and couple it to mitochondrial division. [More]
International project to develop globally accessible bank of new cancer cell models for research

International project to develop globally accessible bank of new cancer cell models for research

An international project to develop a large, globally accessible bank of new cancer cell culture models for the research community launched today. [More]
Pain reliever appears to help preserve vision in animal model of retinal degeneration

Pain reliever appears to help preserve vision in animal model of retinal degeneration

A pain medicine that potently activates a receptor vital to a healthy retina appears to help preserve vision in a model of severe retinal degeneration, scientists report. [More]
Researchers aim to protect kidneys while improving cisplatin's efficacy against cancer

Researchers aim to protect kidneys while improving cisplatin's efficacy against cancer

Cisplatin is a common, powerful chemotherapy agent used for a wide range of cancers such as breast, ovarian and lung, that in a handful of days can also permanently damage or destroy patients' kidneys. [More]
New FDA draft guidelines place tighter restrictions on surgical practices using tissue-based regenerative therapies

New FDA draft guidelines place tighter restrictions on surgical practices using tissue-based regenerative therapies

The therapeutic use of human cell and tissue products is highly regulated by the U.S. government, but a specific exception allows surgeons to harvest, manipulate, and implant tissues in many commonly performed procedures. [More]
UCLA scientists discover cystatin E/M protein that can inhibit cervical cancer growth

UCLA scientists discover cystatin E/M protein that can inhibit cervical cancer growth

UCLA scientists have identified a protein that has the potential to prevent the growth of cervical cancer cells. The discovery could lead to the development of new treatments for the deadly disease. [More]
OIST scientists reveal how big protein complex inside E. coli cells divide and multiply

OIST scientists reveal how big protein complex inside E. coli cells divide and multiply

Escherichia coli (E. coli) are bacteria that live all around and inside of us. Most E. coli are harmless, but some strains can cause illness, and can even, in extreme cases, be deadly. With recent outbreaks of E. coli around the world, there is a fear of acquiring an infection from these bacteria. [More]
Metabolic characteristics of CRPC may open new avenues for treatment

Metabolic characteristics of CRPC may open new avenues for treatment

Advanced prostate cancer is usually treated by removing androgen, the male hormone that helps it grow. Although initially effective, this treatment often leads to the tumor becoming castration resistant- a lethal condition. [More]
Motor protein Myo1c uses actin cytoskeleton as 'track' for Neph1 transport

Motor protein Myo1c uses actin cytoskeleton as 'track' for Neph1 transport

The motor protein Myo1c binds to Neph1, a protein crucial for ensuring effective filtration by the kidney, and serves as one mode of its cellular transport, according to findings by investigators at the Medical University of South Carolina and their collaborators reported in the May 16, 2016 issue of Molecular and Cellular Biology. [More]
Researchers reveal new mechanism that helps breast cancer cells engage MDSCs

Researchers reveal new mechanism that helps breast cancer cells engage MDSCs

Not every breast cancer tumor follows the same path to grow. Some tumors have the assistance of myeloid-derived suppressor cells (MDSCs), a diverse type of immune cell involved in the suppression of the body's response against tumors. [More]
lncRNA in placenta may help protect unborn baby from invading pathogens

lncRNA in placenta may help protect unborn baby from invading pathogens

The human placenta is an organ unlike any other. During the course of nine months it is formed by the embryo, sustains life and then is shed. [More]
Study shows over-expression of adhesion molecules in fat tissues protects mice from obesity, diabetes

Study shows over-expression of adhesion molecules in fat tissues protects mice from obesity, diabetes

Okayama University researchers report that the overexpression of an adhesion molecule found on the surface of fat cells appears to protect mice from developing obesity and diabetes. The findings, published in the journal Diabetes, March 2016, may fuel the development of new therapies targeting these diseases. [More]
Study highlights significance of tiny RNA molecules in tissue regeneration process

Study highlights significance of tiny RNA molecules in tissue regeneration process

Dr. Elizabeth Hutchins, a Post-Doctoral Fellow in TGen's Neurogenomics Division, and co-lead author of the study, said she hopes this investigation eventually enables such things as regenerating cartilage in knees, repairing spinal cords in accident victims, and reproducing the muscles of injured war veterans. [More]
Combination of nanoscale topography and triculture technology benefits large or slow-healing wounds

Combination of nanoscale topography and triculture technology benefits large or slow-healing wounds

Large or slow-healing wounds that do not receive adequate blood flow could benefit from a novel approach that combines a nanoscale graft onto which three different cell types are layered. Proper cell alignment on the nanograft allows for the formation of new blood vessel-like structures, as reported in of Tissue Engineering, Part A, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free for download on the Tissue Engineering website until May 26, 2016. [More]
Brain chemical dopamine plays key role in representing or encoding movement

Brain chemical dopamine plays key role in representing or encoding movement

Princeton University researchers have found that dopamine - a brain chemical involved in learning, motivation and many other functions - also has a direct role in representing or encoding movement. The finding could help researchers better understand dopamine's role in movement-related disorders such as Parkinson's disease. [More]
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