Chemokine News and Research

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Chemokines are a family of small cytokines, or proteins secreted by cells. Proteins are classified as chemokines according to shared structural characteristics such as small size (they are all approximately 8-10 kilodaltons in size), and the presence of four cysteine residues in conserved locations that are key to forming their 3-dimensional shape.

Research examines molecules derived from ticks as potential COVID-19 treatment option

UK-based biotechnology firm ILC Therapeutics is working alongside the University of Oxford to examine the use of Evasins – molecules derived from ticks – as a potential COVID-19 treatment option for patients whose lungs are badly damaged by the virus and face a critical juncture in recovery.

13 May 2020

Octapharma USA supports new COVID-19 clinical trial

Octapharma USA is supporting a new investigator initiated clinical trial led by George Sakoulas, M.D. of Sharp Memorial Hospital in San Diego, California focused on treating the most critical patients at the heart of the coronavirus pandemic, those experiencing respiratory failure who become ventilator dependent.

16 Apr 2020

Statistical modeling technique helps track tumor cell diversity

Cancer cells are a wily adversary. One reason the disease outfoxes many potential treatments is because of the diversity of the cancer cell population. Researchers have found this population difficult to characterize and quantify.

20 Feb 2020

New target protein linked to regulation, movement of tumor-associated macrophages

Developing a therapy to combat cancer remains one of the most difficult challenges in medical research. Cancer owes its notorious identity to the fact that the cancer cells use the host's own immune system to grow and spread, ultimately becoming deadly.

30 Jan 2020

Nanoparticle Trojan horse approach to clearing atherosclerotic plaques

Researchers from Michigan State University and Stanford University have designed special nanoparticles which could break down an atherosclerotic plaque from within. This could prevent heart attacks say researchers. The study titled, “Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis,” was published in the latest issue of the journal Nature Nanotechnology.

29 Jan 2020

Siah2 Gene Control could Help Treat Melanomas More Effectively

To develop improved cancer immunotherapies, it is essential to understand how cancers shut down the natural immune response to foreign antigens. This current study demonstrates how mice lacking the Siah2 gene, fail to develop BRAF-mutation carrying melanoma from the corresponding cells, completely rejecting them. This could help in boosting the anticancer effect of existing specific immune checkpoint inhibitors, such as anti-PD-1 drugs.

10 Jan 2020

Study reveals cellular cross-talk between regulatory T cells and fibroblast cells in pancreatic cancer microenvironment

A multidisciplinary Michigan Medicine team is shedding new light on the role of regulatory T cells in pancreatic cancer -; and, in mouse models, have uncovered a new potential target to improve immunotherapy approaches to the deadly disease.

9 Jan 2020

Novel and targeted cellular product causes cell death in non-Hodgkin lymphoma models

Investigators at Rutgers Cancer Institute of New Jersey have found that a treatment based on a novel cellular product programmed to deliver an overabundance of chimeric antigen receptor causes cell death in non-Hodgkin lymphoma models that are sensitive or resistant to standard therapies.

16 Dec 2019

Scientists develop new method for targeted drug delivery to cancer cells

A team of scientists from Peter the Great St.Petersburg Polytechnic University together with their colleagues developed a method of targeted drug delivery to cancer cells.

13 Dec 2019

Study reveals new mechanism that contributes to bone maintenance and repair

Led by researchers at Baylor College of Medicine, a study published in the journal Cell Stem Cell reveals a new mechanism that contributes to adult bone maintenance and repair and opens the possibility of developing therapeutic strategies for improving bone healing.

9 Dec 2019

Scientists develop a method of targeted drug delivery to cancer cells

A team of scientists from Peter the Great St.Petersburg Polytechnic University together with their colleagues developed a method of targeted drug delivery to cancer cells. The discovery is based on the use of mesenchymal stem cells and microcapsules made of polymeric compounds.

9 Dec 2019

Transitional T cells could help improve cancer immunotherapy

In chronic viral infections and cancer, T cell dysfunction is sure to be observed. A new study to be published in the journal Immunity shows that before these cells are completely exhausted, there is a transitory stage in which some cells are present with features that are characteristic of neither the stem-like T cells nor the mature but exhausted T cells.

4 Dec 2019

Study shows ADA2 is a sensitive, specific biomarker for macrophage activation syndrome

According to new research findings presented at the 2019 ACR/ARP Annual Meeting, adenosine deaminase 2 (ADA2) in the peripheral blood is a sensitive, specific biomarker for macrophage activation syndrome, a potentially life-threatening complication of systemic juvenile idiopathic arthritis (systemic JIA)

10 Nov 2019

Study: Pleural effusions are linked with NSCLC and malignant mesothelioma

Cryopreserved cell-free PE fluid from 101 NSCLC patients, 8 mesothelioma and 13 with benign PE was assayed for a panel of 40 cytokines/chemokines using the Luminex system.

6 Nov 2019

Discovery reveals why newer PD-1 targeted therapies sometimes fail

Researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute report a discovery that helps scientists understand why some tumors lack immune cell infiltration and are therefore unresponsive to newer PD-1 targeted therapies.

23 Oct 2019

Temple researchers win NIH grant to study HIV-related neuroinflammation in context of opioid addiction

The National Institutes of Health has awarded a Temple research team a 5-year, $3.27 million grant to study neuroinflammation following HIV-infection in the context of opioid addiction.

16 Oct 2019

TUM researchers identify complex interactions between bacteria and parasites

A team at the Technical University of Munich has completed the first study of the effects of a simultaneous infection with blood flukes (schistosomes) and the bacterium Helicobacter pylori - a fairly common occurrence in some parts of the world.

19 Sep 2019

Roswell Park moving three-pronged immunotherapy strategy forward with support from DoD grant

A team from Roswell Park Comprehensive Cancer Center is moving a new three-part strategy for treating advanced cancers forward with support from a U.S. Department of Defense grant to Pawel Kalinski, MD, PhD, Vice Chair for Translational Research and Rustum Family Professor for Molecular Therapeutics and Translational Research at the Buffalo, N.Y.-based cancer center.

18 Sep 2019

Researchers take important step towards preventing cancer metastasis

Researchers at the Paul Scherrer Institute, together with colleagues from the pharmaceutical company F. Hoffmann-La Roche AG, have taken an important step towards the development of an agent against the metastasis of certain cancers.

23 Aug 2019

New circulating immune cell could help predict type 1 diabetes risk

A new Finnish study suggests that type 1 diabetes may in part be caused by a novel subset of immune cells. This is because these cells, called peripheral T helper cells, are found to circulate at a higher rate in children with type 1 diabetes of recent onset, as well as in healthy children who later develop the condition.

20 Aug 2019