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Scientists detect gene networks likely to be shared by all CLL patients

Scientists detect gene networks likely to be shared by all CLL patients

Research, involving scientists and doctors at the University of Southampton and Royal Bournemouth Hospital, has identified a network of genes that are likely to be shared by all patients who have chronic lymphocytic leukaemia (CLL). [More]
HDAC inhibitors may help regulate alcoholism-induced anxiety

HDAC inhibitors may help regulate alcoholism-induced anxiety

Epigenetics is the study of changes in organisms caused by modifying gene expression - by alcohol, for example - rather than alteration of the genetic code itself. Recent evidence suggests that alcohol can inhibit activity of an enzyme called histone deacetylase (HDAC) in the amygdala, a brain region that is crucial for storing memories and regulating fear, anxiety, and other emotions. [More]
Researchers identify new potential target for pancreatic cancer treatment

Researchers identify new potential target for pancreatic cancer treatment

Using an innovative approach to identify a cancer's genetic vulnerabilities by more swiftly analyzing human tumors transplanted into mice, researchers have identified a new potential target for pancreatic cancer treatment, published online in Cell Reports. [More]
Drexel University researchers aim to identify new molecular mechanisms involved in chronic pain

Drexel University researchers aim to identify new molecular mechanisms involved in chronic pain

Chronic pain is one of the most prevalent, disabling and expensive public health crises in the United States. It affects more than 100 million Americans, with annual costs estimated at $635 billion, says a 2014 report from the American Pain Society. [More]
Penn researchers help identify unique characteristics of reserve stem cells

Penn researchers help identify unique characteristics of reserve stem cells

Adult stem cells represent a sort of blank clay from which a myriad of different cell and tissue types are molded and as such are of critical importance to health, aging and disease. [More]
Study underscores importance of developing PRMT5 inhibitors as promising treatment for GB patients

Study underscores importance of developing PRMT5 inhibitors as promising treatment for GB patients

A new study suggests that blocking an enzyme called PRMT5 in tumor cells could be a promising new strategy for the treatment of glioblastoma (GB), the most aggressive and lethal form of brain cancer. [More]
Epigenomic alterations play key role in triggering obesity-induced diabetes

Epigenomic alterations play key role in triggering obesity-induced diabetes

Obesity is a risk factor for developing type 2 diabetes, yet not all obese humans develop the disease. In a new study, researchers from the Karolinska Institutet in Sweden and from the Institute of Health and Medical Research in France have identified epigenomic alterations that are associated with inflammation and type 2 diabetes [More]
Research describes how gene BRCA1 plays vital role in DNA repair

Research describes how gene BRCA1 plays vital role in DNA repair

Scientists at the University of Birmingham are a step closer to understanding the role of the gene BRCA1. Changes in this gene are associated with a high risk of developing breast and ovarian cancer. [More]
Unlocking the dark proteome: an interview with Dr Kriwacki

Unlocking the dark proteome: an interview with Dr Kriwacki

The term dark proteome refers to proteins whose structural features and thus functions are not well understood. Many proteins within the dark proteome do not fold into stable three-dimensional structures. These proteins are called intrinsically disordered proteins (IDPs) and feature highly flexible, disordered confirmations. [More]
Genetic change to non-DNA structures in cell can cause cancer

Genetic change to non-DNA structures in cell can cause cancer

A mutation that affects the proteins that package DNA--without changing the DNA itself--can cause a rare form of cancer, according to new findings in this week's Science from researchers at The Rockefeller University. [More]
Study suggests ways of minimizing DNA folding errors

Study suggests ways of minimizing DNA folding errors

Induced pluripotent stem cells hold promise for regenerative medicine because they can, in theory, turn into any type of tissue and because they are made from a patient's own adult cells, guaranteeing compatibility. However, the technique that turns adult cells into these iPS cells is not foolproof; after reverting to their pluripotent state, these cells don't always correctly differentiate back into adult cells. [More]
Study provides new avenues for improving quality, stability of embryonic stem cells

Study provides new avenues for improving quality, stability of embryonic stem cells

Research led by the Babraham Institute with collaborators in the UK, Canada and Japan has revealed a new understanding of how an open genome structure supports the long-term and unrestricted developmental potential in embryonic stem cells. This insight provides new avenues for improving the quality and stability of embryonic stem cells - an essential requirement to fulfil their promise in regenerative medicine. [More]
Discovery of shared biological properties among DNA variants may help identify new therapeutic targets

Discovery of shared biological properties among DNA variants may help identify new therapeutic targets

The discovery of shared biological properties among independent variants of DNA sequences offers the opportunity to broaden understanding of the biological basis of disease and identify new therapeutic targets, according to a collaboration between the Perelman School of Medicine at the University of Pennsylvania, the University of Arizona Health Sciences, and Vanderbilt University. The group published their findings this month in npj Genomic Medicine. [More]
University of Leicester-led researchers solve 3D structure of NuRD complex that plays role in cancer

University of Leicester-led researchers solve 3D structure of NuRD complex that plays role in cancer

A team of researchers led by the University of Leicester has shed new light on how the regulation machinery that controls gene expression works by characterising a complex known as the NuRD complex. [More]
Changes in chromatin structure may promote cancer

Changes in chromatin structure may promote cancer

Cancer development is a complex process involving both genetic and epigenetic changes. Genetic changes in oncogenes and tumor-suppressor genes are generally considered as primary causes, since these genes may directly regulate cellular growth. In addition, it has been found that changes in epigenetic factors, through mutation or altered gene expression, may contribute to cancer development. [More]
Newly discovered player in epigenetic regulation closely linked to known cancer promoters

Newly discovered player in epigenetic regulation closely linked to known cancer promoters

If genes form the body's blueprint, then the layer of epigenetics decides which parts of the plan get built. Unfortunately, many cancers hijack epigenetics to modulate the expression of genes, thus promoting cancer growth and survival. [More]
DNA sequence features predict genome-wide binding pattern of key protein involved in brain disorders

DNA sequence features predict genome-wide binding pattern of key protein involved in brain disorders

Researchers from the University of Illinois at Urbana-Champaign and the University of California-Davis are combining in vivo experimentation with computation for highly accurate prediction of the genome-wide binding pattern of a key protein involved in brain disorders. [More]
Diet-induced obesity, diabetes can be epigenetically inherited by offspring, say scientists

Diet-induced obesity, diabetes can be epigenetically inherited by offspring, say scientists

Scientists at Helmholtz Zentrum M√ľnchen, in collaboration with researchers from Technical University of Munich and the German Center for Diabetes Research, have shown that diet-induced obesity and diabetes can be epigenetically inherited by the offspring via both the oocytes and the sperm. [More]
Scientists find surprising link between iPS cell reprogramming, blood cell formation and cancer

Scientists find surprising link between iPS cell reprogramming, blood cell formation and cancer

The ability to reprogram cells has revolutionized stem cell research with major implications for almost all fields of modern biology. A decade ago Shinya Yamanaka described a procedure that revolutionized stem cell biology. Using a genetic trick that introduces a cocktail of four genes into cultured cells from human biopsies, he was able to generate induced pluripotent stem cells (iPS) from mature skin or blood cells [More]
New screening technique to test drug compounds used in Ewing sarcoma treatment

New screening technique to test drug compounds used in Ewing sarcoma treatment

In Ewing sarcoma, cancer cells' DNA is unwound abnormally from a condensed, compact state. Once sections of genetic code are open, key genes are turned on to help direct aggressive and cancerous cell growth. [More]
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