Chromosomal Crossover News and Research

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Combination therapy achieves greater progression-free survival, response rates in melanoma

Combination therapy with both BRAF inhibitor vemurafenib and MEK inhibitor cobimetinib achieves greater progression-free survival and response rates than vemurafenib plus placebo in BRAF-mutation positive melanoma, according to phase III data presented at the ESMO 2014 Congress in Madrid, Spain.

30 Sep 2014

MicroBiome Therapeutics' NM 505 drug can improve tolerability of metformin

MicroBiome TherapeuticsTM LLC, today reported positive topline results from a proof of concept study testing whether its investigational drug, NM 505, can improve the tolerability of metformin, the first-line therapy for Type 2 diabetes worldwide.

26 Sep 2014

Electroconvulsive therapy combats treatment-resistant schizophrenia

The use of electroconvulsive therapy improves the chances of a treatment response in patients with continued schizophrenia symptoms despite use of antipsychotic medication, a randomised trial shows.

3 Sep 2014

Boehringer Ingelheim announces FDA acceptance of NDA filing for tiotropium and olodaterol FDC

Boehringer Ingelheim today announced that the U.S. Food and Drug Administration accepted for review the New Drug Application (NDA) for the fixed-dose combination (FDC) of tiotropium and olodaterol delivered via the Respimat inhaler for the proposed indication of long-term, once-daily maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema.

21 Aug 2014

Using a nanotech microchip to diagnose type 1 diabetes: an interview with Dr. Brian Feldman, Stanford School of Medicine

The most common form of diabetes is sometimes referred to as metabolic diabetes, which is the diabetes most people are very familiar with, type 2 diabetes. This form of diabetes is most prevalent in people that are overweight or obese. Historically, it has been confined to adults or older patients but it has been on the rise as the global obesity problem has continued to worsen.

20 Aug 2014

Eating pistachios may reduce body's response to stresses among adults with diabetes

Among people with type 2 diabetes, eating pistachios may reduce the body's response to the stresses of everyday life, according to Penn State researchers.

6 Aug 2014

Biochemists report advance in production of functional mirror-image proteins

University of Utah biochemists have reported an advance in the production of functional mirror-image proteins.

29 Jul 2014

Hydroxychloroquine treatment not effective for primary Sjögren syndrome

Among patients with the systemic autoimmune disease primary Sjögren syndrome, use of hydroxychloroquine, the most frequently prescribed treatment for the disorder, did not improve symptoms during 24 weeks of treatment compared with placebo, according to a study in the July 16 issue of JAMA.

16 Jul 2014

Consuming fresh avocado with tomatoes or carrots enhances provitamin A absorption

Consuming a whole fresh avocado with either an orange-colored tomato sauce or raw carrots significantly enhanced provitamin A carotenoid (alpha- and beta-carotene) absorption and conversion of these carotenoids to an active form of vitamin A, according to new research (1) published in The Journal of Nutrition.

11 Jul 2014

Lower back pain not triggered by weather changes according to new study

Episodes of lower back pain are not triggered by changes in weather conditions, say Australian researchers.

10 Jul 2014

Acute episodes of low back pain not linked to weather conditions

Australian researchers reveal that sudden, acute episodes of low back pain are not linked to weather conditions such as temperature, humidity, air pressure, wind direction and precipitation.

10 Jul 2014

Cidara Therapeutics closes $32M Series A financing to advance novel echinocandin antifungal drug

Cidara Therapeutics, Inc., a privately held biopharmaceutical company, announced today that it has completed a $32 million Series A financing that will enable it to advance candidates from the company's Cloudbreak™ targeted immunotherapy platform and biafungin™, a novel long acting echinocandin antifungal drug, into human clinical studies.

30 Jun 2014

Vertex receives positive opinion from European CHMP for approval of KALYDECO for cystic fibrosis

Vertex Pharmaceuticals Incorporated today announced that the European Committee for Medicinal Products for Human Use has issued a positive opinion recommending the approval of KALYDECO (ivacaftor) for people with cystic fibrosis (CF) ages 6 and older who have one of eight non-G551D gating mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.

28 Jun 2014

Trevena's Phase 1b data for TRV130 published in the journal Pain

Trevena, Inc., a clinical stage biopharmaceutical company and the leader in the discovery of G protein coupled receptor (GPCR) biased ligands, today announced the publication of its Phase 1b data for TRV130 in the journal Pain.

24 Jun 2014

Clinical trial shows that selumetinib drug can delay progression of metastatic uveal melanoma

For the first time, a therapy has been found that can delay progression of metastatic uveal melanoma, a rare and deadly form of melanoma of the eye.

20 Jun 2014

Instant oatmeal provides greater satiety than equal calories of ready-to-eat oat cereal

New research published in the Nutrition Journal reveals that calorie-for-calorie, even a serving of instant oatmeal is more filling than a ready-to-eat (RTE), oat-based cereal.

11 Jun 2014

Pivotal Therapeutics reports reduced revenue in first quarter 2014

Pivotal Therapeutics Inc., ("Pivotal" or the "Company"), a specialty pharmaceutical company with a focus on Omega-3 therapies for cardiovascular disease (CVD) and overall health, announced its operational highlights and financial results for the three months ended March 31, 2014.

31 May 2014

Global scientists to discuss latest findings on diagnosis, causes and treatments of ASD

The International Society for Autism Research (INSAR), a scientific and professional organization devoted to advancing knowledge about autism spectrum disorders, convened more than 1700 researchers, delegates, autism specialists and students from 40 countries for the 13th Annual International Meeting for Autism Research (IMFAR), the world's largest scientific gathering on autism research, from May 15 through May 17 at the Atlanta Marriott Marquis in Atlanta, GA.

15 May 2014

Purdue Pharma seeks FDA authorization to market once-daily hydrocodone bitartrate tablet

Purdue Pharma L.P. announced that it has filed a New Drug Application (NDA) with the U.S. Food & Drug Administration seeking authorization to market a once-daily, single-entity hydrocodone bitartrate tablet (HYD).

30 Apr 2014

Studies reveal effect of almonds on diet quality, appetite, adiposity and cardiovascular disease risk factors

Six new almond-related research studies will be presented next week in San Diego at the American Society of Nutrition (ASN)'s Scientific Sessions and Annual Meeting, held in conjunction with Experimental Biology 2014 (EB).

26 Apr 2014