Cocaine dependence (or addiction) is physical and psychological dependency on the regular use of cocaine. It can result in severe physiological damage, psychosis, schizophrenia, lethargy, depression, or a potentially fatal overdose.
Consumption of the synthetic drug MDPV -a powerful psychostimulant known as 'cannibal drug'- in adolescence, can increase vulnerability of cocaine addiction during adulthood, according to a study carried out with laboratory animals and led by the researchers Elena Escubedo, from the Faculty of Pharmacy and Food Sciences and the Institute of Biomedicine of the UB and Olga Valverde, head of the Neurobiology of Behaviour Research Group of Pompeu Fabra University.
The hypocretin/orexin (HCRT) system of the brain is best known for promoting wakefulness and appetite. A new paper in Biological Psychiatry suggests that blocking hypocretin signaling via the HCRT-1 receptor (HCRT-R1) might also reduce the appetite for cocaine.
A University of Cincinnati researcher who has developed an immunotherapy to help reverse cocaine addiction that's been successful in animal models says he hopes to have it in clinical trials in human volunteers within a year.
Cocaine addiction may affect how the body processes iron, leading to a build-up of the mineral in the brain, according to new research from the University of Cambridge.
People addicted to cocaine make riskier decisions than healthy people after losing a potential reward, according to a study published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.
Identifying more effective treatment strategies tailored to individual responses for patients overcoming addiction to cocaine is the focus of a new clinical trial at McGovern Medical School at The University of Texas Health Science Center at Houston.
A DGIST research team led by Professor Su-Il In, who developed acupuncture needles combined with nanotechnology, was recognized as the world's first application of this technology.
A team of researchers led by Cardiff University has discovered a promising new drug treatment for cocaine addiction.
An international team led by scientists at The Scripps Research Institute has found strong evidence supporting a new strategy against drug addiction.
A new study from scientists at The Scripps Research Institute, funded by the National Institutes of Health's National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, suggests that increased levels of a molecule in the brain, called hypocretin, may contribute to cocaine addiction.
Researchers at The University of Texas at Arlington are studying how fluctuating estrogen levels make females increasingly sensitive to the rewarding effects of cocaine and ultimately, vulnerable to cocaine addiction.
Scientists at Wake Forest Baptist Medical Center are one step closer to understanding what causes cocaine to be so addictive. The research findings are published in the current issue of the Journal of Neuroscience.
Addiction may be viewed as a disorder of reward learning. To date, addiction research has focused on the molecular adaptations through which memories of exposure to abused substances are encoded and maintained by nerve cells.
Scientists at USC have developed a new tool to modify brain activity and memory in targeted ways, without the help of any drugs or chemicals.
In the ongoing fight against drug addiction, researchers from the University of Pennsylvania's School of Nursing and Perelman School of Medicine have discovered a unique application for an FDA-approved drug currently used for obese patients and type 2 diabetics: treatment for cocaine dependence.
Combining the drug topiramate with psychological counseling curbed marijuana use among young smokers significantly more than did counseling alone, according to newly published results of a small randomized, controlled trial at Brown University. The results come with a caveat, however: many study volunteers couldn't tolerate the medicine's side effects.
University of Kentucky College of Pharmacy Professor Chang-Guo Zhan, along with fellow UK Professors Fang Zheng and Sharon Walsh, and Professor Mei-Chuan Ko from Wake Forest University, recently received $6 million in funding over five years to further develop a potential treatment for cocaine abuse.
A long-acting enzyme that rapidly and safely metabolizes cocaine in the blood stream is currently being investigated in animal models as a possible treatment for cocaine overdose.
Abstinence is the best way to avoid drug addiction. But in many societies, drug use is the norm, not the exception, especially by youth.
Researchers at the University at Buffalo have discovered a previously unknown neural pathway that can regulate changes made in the brain due to cocaine use, providing new insight into the molecular basis of cocaine addiction.