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SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

In a recent study posted to the bioRxiv* preprint server, researchers at Weill Cornell Medical College assessed the cleavability of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and related coronaviruses by several proteases of the host.

19 Jun 2022

New evidence confirms that enterovirus D68 causes acute flaccid myelitis

A case report published in the New England Journal of Medicine provides evidence that enterovirus D68 directly infects spinal cord neurons and that a corresponding robust immune response is present – a direct causation to the polio-like paralyzing illness, acute flaccid myelitis (AFM).

26 May 2022

Engineered water nanostructures as a new technology against SARS-CoV-2

In a recent study published in the MDPI journal Nanomaterials, a research group from the United States (US) has shown the possibility of inactivating surrogates of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on surfaces with the use of specific water nanostructures incorporated with nature-derived antimicrobials.

24 May 2022

Studies provide insight into how long COVID-19 immunity lasts and nature of immune recall

How does the immune system remember and recognize viral invaders it has encountered in the past? A trio of newly published studies of people infected with SARS-CoV-2, vaccinated against the virus or both, are providing tantalizing new clues about the factors that influence the speed and magnitude of the immune system's response to subsequent infection with variants of SARS-CoV-2.

19 May 2022

Clonality and magnitude of SARS-CoV-2-reactive CD4+ T cells in COVID-19 convalescent patients after vaccination

A new study has focussed on determining the clonality and levels of SARS-CoV-2-reactive CD4+ T cells in CCPs post-vaccination.

12 May 2022

Evidence of croup associated with SARS-CoV-2

A new study published in the Journal of Pediatric Infectious Diseases Society aimed to characterize the clinical features of SARS-CoV-2-associated croup among children presenting to the ED during the phase when Omicron variant transmission was high.

9 May 2022

Infection with SARS-CoV-2 results in antibodies against common colds

A study published in the journal Science Advances uses electron microscopy-based polyclonal epitope mapping (EMPEM) methodology to elucidate the spike epitopes of β-HCoV targeted by preexisting serum antibodies and compares them to the epitopes targeted by antibodies elicited by SARS-CoV-2 infection using electron microscopy-based polyclonal epitope mapping (EMPEM) methodology.

8 May 2022

Study investigates stress granule formation during infection with the human common cold coronavirus and SARS-CoV-2

Researchers analyzed the inhibition of stress granules formation in cells infected by the human common cold coronavirus HCOV-OC43 and SARS-CoV-2.

5 May 2022

The added value of adequate immune fitness to the existing approaches to pandemic preparedness

Researchers described two studies, the CLOFIT retrospective study and the COTEST real-time study, that investigated if maintaining adequate immune fitness could significantly add to the current strategies of preparedness for COVID-19 and other pandemics.

28 Apr 2022

Free fatty acid-binding pocket found to be preserved across spike proteins of beta coronaviruses

Researchers assessed the binding pocket of linoleic acid, an essential free-fatty acid in the receptor-binding domains of the spike protein of beta-coronaviruses.

26 Apr 2022

Nurseries, schools, nursing homes and other indoor settings exposed to high levels of respiratory pathogens during winter

High levels of respiratory pathogens are present in the air of nurseries, schools, nursing homes and other indoor settings during winter, according to new research being presented at this year's European Congress of Clinical Microbiology & Infectious Diseases in Lisbon, Portugal, (23-26 April).

23 Apr 2022

Common dishwashing detergents may eliminate coronaviruses from glass

Common dishwashing detergents and scrubbing devices found to be sufficient to inactivate and eliminate human coronaviruses from glass surfaces.

10 Apr 2022

Transcriptional reprogramming of monocytes in COVID-19

In a recent study posted to the bioRxiv* server, researchers examined the functionality of cluster of differentiation 14-positive (CD14+) monocytes in patients with mild or moderate coronavirus disease 2019 (COVID-19).

7 Apr 2022

Study evaluates the presence of the SARS-CoV-2 spike protein in urine samples collected during the COVID-19 pandemic

A study published analyzed the presence of SARS-CoV-2 spike protein in urine samples of the infected patients.

6 Apr 2022

Swedish HCW study shows COVID booster shots have limited effect on Omicron

Researchers examine emerging infections in healthcare workers who received the booster vaccination either with or without prior SARS-CoV-2 infection.

5 Apr 2022

Genetic risk for asthma may be mediated through altered gene expression in the airway cells

A significant amount of genetic risk for asthma is likely mediated through altered gene expression within the airway epithelium.

28 Mar 2022

Study confirms no preexisting B-cell immunity against SARS-CoV-2 in pre-pandemic samples

A recent study finds that there is no considerable B-cell immunity against SARS-CoV-2 in unexposed healthy individuals.

23 Mar 2022

Croup: A previously unrecognized complication of COVID-19 in young children

The omicron surge has led to a previously unrecognized complication of COVID-19 in young children: croup. In the first peer-reviewed report to date, physicians at Boston Children's Hospital describe 75 children who came to the hospital's emergency department (ED) with croup and COVID-19 from March 1, 2020 through January 15, 2022.

15 Mar 2022

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

A new study used glycoprotein profiling technology platform that couples high-resolution LC-MS for glycoprotein analysis in regards to COVID-19.

9 Mar 2022

Clinical trial of novel rabies vaccine in human volunteers begins in Tanzania

The University of Oxford and the Ifakara Health Institute today announced the vaccination of the first participants in a Phase Ib/II trial testing a novel rabies vaccine in human volunteers in Tanzania.