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Children born with CHD more likely to develop type 2 diabetes in adulthood

Children born with CHD more likely to develop type 2 diabetes in adulthood

Children born with heart disease have an increased risk of developing type 2 diabetes after age 30, according to a new study. [More]
Study identifies genetic mutations responsible for development of cardiac hypertrophy in adults

Study identifies genetic mutations responsible for development of cardiac hypertrophy in adults

Investigators at Beth Israel Deaconess Medical Center have identified a developmental cause of adult-onset cardiac hypertrophy, a dangerous thickening of the heart muscle that can lead to heart failure and death. [More]
Innovative website reveals NHS children's heart surgery statistics to decision makers and parents

Innovative website reveals NHS children's heart surgery statistics to decision makers and parents

Researchers are calling for the end to an era of confusion and alarm about children's heart surgery statistics by launching an innovative communication tool that will help people make sense of published survival data about children's heart surgery in the UK and Ireland. [More]
New blood test could help predict severity of pulmonary arterial hypertension

New blood test could help predict severity of pulmonary arterial hypertension

Johns Hopkins Medicine researchers report that rising blood levels of a protein called hematoma derived growth factor (HDGF) are linked to the increasing severity of pulmonary arterial hypertension, a form of damaging high blood pressure in the lungs. [More]
Scientists aim to heal failing heart with the body’s own cells

Scientists aim to heal failing heart with the body’s own cells

Babies born with heart defects live longer than ever thanks to advances in the diagnosis and treatment of congenital heart disease. Yet, despite substantial progress, many continue to face bleak odds, lifelong medication, multiple surgeries and progressive heart failure, often requiring a transplant. [More]
First-ever clinical trial of bioabsorbable cardiovascular device in children shows promise

First-ever clinical trial of bioabsorbable cardiovascular device in children shows promise

Current cardiovascular valve or blood vessel implants are generally associated with a number of complications, have limited efficacy over time, and may necessitate repeated interventions over a patient's lifetime, especially when implanted in a young child. [More]
Japanese surgeons develop new technique to relieve airway obstruction in children

Japanese surgeons develop new technique to relieve airway obstruction in children

Several pediatric medical conditions, such as congenital heart disease, vascular compression, and congenital softening of the cartilage lining the trachea or bronchi, can compromise the airway and cause breathing difficulty. [More]
Clinicians describe placement of first implantable hemodynamic monitor in single ventricle Fontan anatomy

Clinicians describe placement of first implantable hemodynamic monitor in single ventricle Fontan anatomy

While the Fontan procedure has improved the short- and mid-term outcomes for patients born with single ventricle anatomy, long-term complications of Fontan circulation include heart failure. These complications are thought to be secondary to elevated central venous pressure, chronic venous congestion and low cardiac output. [More]
Acid suppression drugs frequently prescribed for high-risk newborns, study shows

Acid suppression drugs frequently prescribed for high-risk newborns, study shows

Since 2006, several published studies have associated the use of some acid suppression medications in hospitalized high-risk babies with infections, necrotizing enterocolitis and increased risk of death. Those medications - histamine-2 receptor antagonists, such as ranitidine (Zantac and others), and proton pump inhibitors, such as esomeprazole (Nexium and others) - were originally approved by the U.S. Food and Drug Administration for use in adults and older children. [More]
Pediatric researchers develop minimally invasive techniques to treat plastic bronchitis

Pediatric researchers develop minimally invasive techniques to treat plastic bronchitis

Pediatric researchers have devised an innovative, safe and minimally invasive procedure that helps relieve rare but potentially life-threatening airway blockages occurring in children who had surgery for congenital heart defects. [More]
Boston Children's, Edwards Lifesciences launch new prosthetic heart valve study for congenital heart defect

Boston Children's, Edwards Lifesciences launch new prosthetic heart valve study for congenital heart defect

Surgeons in the Heart Center at Boston Children's Hospital have partnered with Edwards Lifesciences to launch a clinical study of a new prosthetic heart valve for patients born with a congenital heart defect. [More]
Anti-anxiety drug reduces autistic features in Jacobsen syndrome mice

Anti-anxiety drug reduces autistic features in Jacobsen syndrome mice

About half of children born with Jacobsen syndrome, a rare inherited disease, experience social and behavioral issues consistent with autism spectrum disorders. Researchers at University of California, San Diego School of Medicine and collaborators developed a mouse model of the disease that also exhibits autism-like social behaviors and used it to unravel the molecular mechanism that connects the genetic defects inherited in Jacobsen syndrome to effects on brain function. [More]
Adults living with congenital heart disease may have higher risk of PTSD

Adults living with congenital heart disease may have higher risk of PTSD

Adults living with congenital heart disease (CHD) may have a significantly higher risk of post-traumatic stress disorder (PTSD) than people in the general population. [More]
TBX5 gene expression could play key role in congenital heart disease

TBX5 gene expression could play key role in congenital heart disease

Congenital heart disease is the most common birth defect and the leading cause of all infant deaths in the United States. Mutations in the gene TBX5 have been shown to cause both rare and more prevalent forms of congenital heart disease, yet the underlying mechanisms have remained unclear. [More]
ISHLT issues new list of criteria to determine patient eligibility for heart transplant

ISHLT issues new list of criteria to determine patient eligibility for heart transplant

To determine patient eligibility for heart transplant, the International Society for Heart Lung Transplantation maintains a list of criteria, first issued in 2006, that acts as a guideline for physicians. [More]
LifeVest wearable cardioverter defibrillator approved for children at risk for sudden cardiac arrest

LifeVest wearable cardioverter defibrillator approved for children at risk for sudden cardiac arrest

The U.S. Food and Drug Administration today approved a new indication for the LifeVest wearable cardioverter defibrillator. The LifeVest is approved for certain children who are at risk for sudden cardiac arrest, but are not candidates for an implantable defibrillator due to certain medical conditions or lack of parental consent. [More]
CAP2 gene responsible for cardiac conduction disease in mice

CAP2 gene responsible for cardiac conduction disease in mice

The presence or absence of the CAP2 gene causes sudden cardiac death in mice, according to new research from the Perelman School of Medicine at the University of Pennsylvania. In particular, the absence of the gene interrupts the animal's ability to send electrical signals to the heart to tell it to contract, a condition called cardiac conduction disease. [More]
New biobank initiative may help unlock some of the mysteries linked to Down syndrome

New biobank initiative may help unlock some of the mysteries linked to Down syndrome

Nationwide Children's Hospital and research advocacy group DownSyndrome Achieves have joined forces to create the first biobank in the country dedicated to collecting and managing blood samples from people with Down syndrome. [More]
Early promise for pulmonary artery denervation in PAH patients

Early promise for pulmonary artery denervation in PAH patients

Pulmonary artery denervation is feasible and may reduce pulmonary arterial pressure in patients with pulmonary arterial hypertension, phase II findings suggest. [More]
Study finds link between congenital heart disease and neurodevelopmental disorders

Study finds link between congenital heart disease and neurodevelopmental disorders

Researchers from Columbia University Medical Center, NewYork-Presbyterian, the Pediatric Cardiac Genetics Consortium, and the Pediatric Heart Network have found a number of genetic mutations that explain why many children with congenital heart disease also have other significant health challenges, including neurodevelopmental disorders and other congenital problems. [More]
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