Cox 2 Inhibitor News and Research

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Cox-2 Inhibitors are nonsteroidal anti-inflammatory drugs used to relieve pain and inflammation. COX-2 inhibitors are being studied in the prevention of colon polyps, and as anticancer drugs. Also called cyclo-oxygenase-2 inhibitor.

Study: Short-term use of COX-2 inhibitors may help prevent gastric cancer

Elevated expression of COX-2 is observed in a wide variety of human malignancies, including gastric cancer. Long-term high dose COX-2 inhibitors can inhibit gastric carcinogenesis in animal models, but the possible life-threatening cardiovascular adverse events limit its popular application. Therefore, it is important to evaluate the optimal intervention point of COX-2 inhibitors for inhibiting H. pylori-associated gastric carcinogenesis.

29 Oct 2009

Researchers devise a live cell morphological profiling approach using the xCELLigence RTCA System

The extent to which protein targets are modulated by drugs or small molecule compounds depends on a number of factors, including the expression levels of the target, the effective concentration of the compound, and the time needed for the compound to perturb the target. To address these restrictions, researchers Abassi et al. (1) have devised a live cell morphological profiling approach for dynamic monitoring of the effect of small molecule compounds that was based on impedance measurement of cells with the xCELLigence RTCA System of Roche Applied Science.

27 Aug 2009

Regular use of aspirin after colorectal cancer diagnosis may reduce the risk of cancer death

In the August 12 issue of the Journal of the American Medical Association, the study's authors also find that the aspirin-associated survival advantage was seen primarily in patients with tumors expressing the COX-2 enzyme, a characteristic of two-thirds of colorectal cancers.

11 Aug 2009

Discovery in colon cancer prevention

A new study finds that individuals who have low expression of the "Celebrex gene," 15-PGDH, are actually resistant to Celebrex treatment when used to prevent colon cancer.

18 May 2009

New findings on COX-2 inhibitor side effects

In searching for a simple way to identify individuals with smoking-related lung injury, scientists at Weill Cornell Medical College have stumbled upon a potential explanation for why the class of pain-relievers known as COX-2 inhibitors increases the risk of heart problems among users.

29 Apr 2009

Fewer hospitalizations for bleeding in digestive system

Improved treatments for acid reflux disease, ulcers, arthritis and other conditions helped reduce hospital admission rates for internal bleeding in the upper gastrointestinal tract by 14 percent from 1998 to 2006, according to the latest News and Numbers from the Agency for Healthcare Research and Quality.

18 Dec 2008

New therapeutic approaches to protect neurons from inflammation and toxicity-induced neurodegeneration

New research led by Chu Chen, PhD, Associate Professor of Neuroscience at LSU Health Sciences Center New Orleans, provides evidence that one of the only naturally occurring fatty acids in the brain that has the ability to interact with the receptors originally identified as the targets of THC (the psychoactive component of marijuana) can help to protect brain cells from neurodegenerative diseases like Alzheimer's and Parkinson's.

20 Aug 2008

Appeals courts overturn two verdicts, judgment on award payment in Vioxx lawsuits

State appeals courts in New Jersey and Texas on Thursday reversed two jury verdicts and a judgment on payment of legal fees in lawsuits related to the COX-2 inhibitor Vioxx that would have required Merck to pay about $37 million, Bloomberg/Washington Post reports (Van Voris/Voreacos, Bloomberg/Washington Post, 5/30).

30 May 2008

Merck agrees to pay $58 million to aettle multistate lawsuit that claimed advertisements for Vioxx played down health risks

Merck on Tuesday agreed to a $58 million settlement with 29 states and the District of Columbia to end investigations over allegations that it downplayed cardiovascular risks caused by the COX-2 inhibitor Vioxx in direct-to-consumer advertisements dating back to 1999, the AP/Philadelphia Inquirer reports (Raffaele, AP/Philadelphia Inquirer, 5/21).

21 May 2008

New York Times examines opposition to proposed off-label promotion guidelines amid allegations of ghostwriting

The New York Times on Saturday examined how a recent report indicating that Merck used "ghostwriters" to produce medical journal articles in support of the COX-2 inhibitor Vioxx "has galvanized opponents to a federal proposal that would relax some restrictions on drug promotion" in the U.S.

21 Apr 2008

Sen. Grassley sends letter to Merck requesting explanation of recent JAMA reports

Sen. Chuck Grassley (R-Iowa) has sent a letter to Merck Chief Operating Officer Richard Clark requesting the company explain a recent report that found the company used employees or paid consultants rather than the physicians listed as lead authors to write several published studies of the COX-2 inhibitor Vioxx, CQ HealthBeat reports.

18 Apr 2008

Pine bark naturally reduces osteoarthritis knee pain

Affecting more than 10 million Americans, Osteoarthritis of the knee (OA) is one of the five leading causes of disability among the elderly.

5 Dec 2007

Osteoarthritis drug Prexige withdrawn from Canadian market

Health authorities in Canada have withdrawn the osteoarthritis drug Prexige from the market amid concerns the drug increases the risk for serious liver-related damage including hepatitis.

4 Oct 2007

Nimesulide delays pancreatic cancer precursors in mice

Nimesulide, a cyclooxygenase-2 (COX-2) inhibitor, delays the progression of precancerous pancreatic lesions in mice, according to researchers at David Geffen School of Medicine at UCLA.

2 Aug 2007

COX-2 inhibitors delay pancreatic cancer precursors in mice

Nimesulide, a cyclooxygenase-2 (COX-2) inhibitor, delays the progression of precancerous pancreatic lesions in mice, according to researchers at David Geffen School of Medicine at UCLA.

1 Aug 2007

Researchers look at benefits of aspirin for colon cancer prevention

A colon cancer researcher at the Ireland Cancer Center of University Hospitals Case Medical Center (UHCMC) has laid out the roadmap for how medical science should employ aspirin and new aspirin-like drugs for use in preventing colon cancer in certain high-risk individuals.

24 May 2007

Cox 2 Inhibitor News and Research

Study: Short-term use of COX-2 inhibitors may help prevent gastric cancer

Researchers devise a live cell morphological profiling approach using the xCELLigence RTCA System

Regular use of aspirin after colorectal cancer diagnosis may reduce the risk of cancer death

Discovery in colon cancer prevention

New findings on COX-2 inhibitor side effects

Fewer hospitalizations for bleeding in digestive system

New therapeutic approaches to protect neurons from inflammation and toxicity-induced neurodegeneration

Appeals courts overturn two verdicts, judgment on award payment in Vioxx lawsuits

Merck agrees to pay $58 million to aettle multistate lawsuit that claimed advertisements for Vioxx played down health risks

New York Times examines opposition to proposed off-label promotion guidelines amid allegations of ghostwriting

Sen. Grassley sends letter to Merck requesting explanation of recent JAMA reports

Pine bark naturally reduces osteoarthritis knee pain

Osteoarthritis drug Prexige withdrawn from Canadian market

Nimesulide delays pancreatic cancer precursors in mice

COX-2 inhibitors delay pancreatic cancer precursors in mice

Researchers look at benefits of aspirin for colon cancer prevention

Celecoxib offers promise for premature babies

Ibuprofen interferes with the blood thinning properties of aspirin in patients at high risk for cardiovascular disease

iIbuprofen may increase likelihood of heart problems in osteoarthritis patients

Inhaled Celecoxib shows new promise for lung cancer treatment

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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