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Solid-state NMR in structural biology: an interview with Professor Tatyana Polenova

Solid-state NMR in structural biology: an interview with Professor Tatyana Polenova

My research lab studies several classes of systems. We are mostly interested in looking at large protein assemblies to understand their structure, dynamics and how their properties relate to their malfunction in disease. [More]
Scientists begin research work at new £650 million Francis Crick Institute building

Scientists begin research work at new £650 million Francis Crick Institute building

The first scientists have moved into the new £650 million Francis Crick Institute building in London and are starting work in their purpose-built labs. [More]
Research could pave way for more effective and safer anti-epilepsy drugs

Research could pave way for more effective and safer anti-epilepsy drugs

Columbia University Medical Center researchers have discovered how a new epilepsy drug works, which may lead the way to even more effective and safer medications. [More]
Research findings of protein may form foundation for new approach to antibiotics

Research findings of protein may form foundation for new approach to antibiotics

Researchers have made the first-ever detailed, atomic-level images of a peroxiredoxin, which has revealed a peculiar characteristic of this protein and might form the foundation for a new approach to antibiotics. [More]
Mitosis study identifies new potential target for cancer therapy

Mitosis study identifies new potential target for cancer therapy

Structural biologists show in a new study that an apparently key step in the process of cell division depends on a unique interaction among specific proteins, including one that is strongly linked to cancer. Their hope now is that the detailed new characterization of the interaction will make it a target for exploring a new cancer therapy. [More]
Atomic level analysis reveals how two classes of calcium channel blockers produce different effects

Atomic level analysis reveals how two classes of calcium channel blockers produce different effects

An atomic level analysis has revealed how two classes of calcium channel blockers, widely prescribed for heart disease patients, produce separate therapeutic effects through their actions at different sites on the calcium channel molecule. [More]
EPFL scientists discover new path to combat pathogenic bacteria

EPFL scientists discover new path to combat pathogenic bacteria

Bacteria that cause tuberculosis, leprosy and other diseases, survive by switching between two different types of metabolism. [More]
Novel nanoscale display case could help reveal structure of hard-to-study molecules

Novel nanoscale display case could help reveal structure of hard-to-study molecules

Researchers at the Department of Energy's Lawrence Berkeley National Laboratory and UC Berkeley have created a sort of nanoscale display case that enables new atomic-scale views of hard-to-study chemical and biological samples. [More]
Researchers develop new hybrid method to study HIV protein involved in disease progression

Researchers develop new hybrid method to study HIV protein involved in disease progression

More than 36 million people worldwide, including 1.2 million in the U.S., are living with an HIV infection. Today's anti-retroviral cocktails block how HIV replicates, matures and gets into uninfected cells, but they can't eradicate the virus. [More]
Scientists unveil structure of Zika NS1 protein

Scientists unveil structure of Zika NS1 protein

Researchers have revealed the molecular structure of a protein produced by the Zika virus that is thought to be involved in the virus's reproduction and its interaction with a host's immune system. [More]
Neutrons key to discovering new HIV drugs? An interview with Dr Matthew Blakeley

Neutrons key to discovering new HIV drugs? An interview with Dr Matthew Blakeley

Neutron crystallography allows us to determine the three-dimensional structures of biological macromolecules, such as proteins, by means of the diffraction of neutrons from the regularly spaced atoms of a crystal. [More]
Scientists capture new images of calcium-shuttling molecule linked to aggressive cancers

Scientists capture new images of calcium-shuttling molecule linked to aggressive cancers

Scientists have captured new images of a calcium-shuttling molecule that has been linked to aggressive cancers. The three-dimensional structure could help researchers develop novel therapies and diagnostic tools for diseases that are caused by a malfunction in calcium adsorption. [More]
Findings offer renewed hope for speedy development curative medicines for people with toxoplasmosis

Findings offer renewed hope for speedy development curative medicines for people with toxoplasmosis

In the July 14 edition of Scientific Reports (Nature), 39 researchers from 14 leading institutions in the United States, United Kingdom and France suggest novel approaches that could hasten the development of better medications for people suffering from toxoplasmosis. [More]
Researchers reveal molecular mechanism of autophagy initiation

Researchers reveal molecular mechanism of autophagy initiation

Researchers revealed that Atg13 links autophagy initiation factors to each other using a string-like conformation, thereby promoting the association of diverse elements of the autophagy initiation machinery, initiating autophagosome formation through the recruitment of Atg9 vesicles and phosphorylation of various Atg factors. [More]
Researchers uncover sensing mechanism of food poisoning bacteria found in shellfish

Researchers uncover sensing mechanism of food poisoning bacteria found in shellfish

UT Southwestern Medical Center researchers have uncovered a mechanism that a type of pathogenic bacteria found in shellfish use to sense when they are in the human gut, where they release toxins that cause food poisoning. [More]
Scientists isolate antibodies capable of neutralizing dengue and Zika virus

Scientists isolate antibodies capable of neutralizing dengue and Zika virus

Scientists from the Institut Pasteur and the CNRS, in collaboration with Imperial College London and the University of Vienna, Austria, have identified antibodies that can efficiently neutralize both the dengue virus and the Zika virus. [More]
UT Southwestern study offers more insight into cholesterol transporter

UT Southwestern study offers more insight into cholesterol transporter

Using X-ray crystallography, UT Southwestern Medical Center researchers have determined the 3-D atomic structure of a human sterol transporter that helps maintain cholesterol balance. [More]
Breakthrough study observes structural changes in carbonic anhydrase for first time

Breakthrough study observes structural changes in carbonic anhydrase for first time

A new study by an international team of researchers, affiliated with Ulsan National Institute of Science and Technology has announced that they have succeeded for the first time in observing the structural changes in carbonic anhydrase. [More]
Understanding structure of HIV-1 protease vital to development of next-generation HIV drugs

Understanding structure of HIV-1 protease vital to development of next-generation HIV drugs

HIV, the virus that causes AIDS, has become one of the world’s most serious health and development challenges. [More]
Cryo-EM technique allows researchers to visualize large transcription PICs at near-atomic resolution

Cryo-EM technique allows researchers to visualize large transcription PICs at near-atomic resolution

An unprecedented molecular view of the critical early events in gene expression, a process essential for all life, has been provided by researchers at Georgia State University, the University of California at Berkeley and Northwestern University. [More]
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