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Researchers unravel bacterial protein structure that could pave way for new antibiotics

Researchers unravel bacterial protein structure that could pave way for new antibiotics

Bacterial cells have an added layer of protection, called the cell wall, that animal cells don't. Assembling this tough armor entails multiple steps, some of which are targeted by antibiotics like penicillin and vancomycin. [More]
Study provides fundamental insights into functioning of microbiota and human-gut flora symbiosis

Study provides fundamental insights into functioning of microbiota and human-gut flora symbiosis

The researchers, led by Professor Bert van den Berg and Dr. David Bolam from the Institute of Cell and Molecular Biosciences at Newcastle University and with support from collaborators at Jacobs University Bremen, report on their findings today in Nature. [More]
Developing high field solid-state NMR for the characterization of complex targets

Developing high field solid-state NMR for the characterization of complex targets

Solid-state NMR spectroscopy is a technique used by scientists to provide valuable information in the analysis of solid materials. It provides unique and specific insights into the structure, dynamics, and reactivity of all kinds of materials. [More]
Researchers provide clues to how mcr-1 gene protects bacteria from 'last resort' antibiotic

Researchers provide clues to how mcr-1 gene protects bacteria from 'last resort' antibiotic

An international research team, led by the University of Bristol, has provided the first clues to understand how the mcr-1 gene protects bacteria from colistin - a 'last resort' antibiotic used to treat life-threatening bacterial infections that do not respond to other treatment options. [More]
Scientists reveal chemical process behind anti-cancer properties of spicy pepper plant

Scientists reveal chemical process behind anti-cancer properties of spicy pepper plant

UT Southwestern Medical Center scientists have uncovered the chemical process behind anti-cancer properties of a spicy Indian pepper plant called the long pepper, whose suspected medicinal properties date back thousands of years. [More]
TSRI researchers develop new approach to find how environmental estrogens impact public health

TSRI researchers develop new approach to find how environmental estrogens impact public health

Breast cancer researchers from the Florida campus of The Scripps Research Institute have developed a novel approach for identifying how chemicals in the environment—called environmental estrogens—can produce infertility, abnormal reproductive development, including “precocious puberty,” and promote breast cancer. [More]
TSRI scientists develop new approach for understanding diverse effects of endocrine-disruptors

TSRI scientists develop new approach for understanding diverse effects of endocrine-disruptors

Breast cancer researchers from the Florida campus of The Scripps Research Institute (TSRI) have developed a novel approach for identifying how chemicals in the environment--called environmental estrogens--can produce infertility, abnormal reproductive development, including "precocious puberty," and promote breast cancer. [More]
TSRI scientists shed light on how antiviral drug stops influenza infections

TSRI scientists shed light on how antiviral drug stops influenza infections

A new study led by scientists at The Scripps Research Institute (TSRI) is the first to show exactly how the drug Arbidol stops influenza infections. The research reveals that Arbidol stops the virus from entering host cells by binding within a recessed pocket on the virus. [More]
Microseeding could be potential method for overcoming hemihedral twinning in protein crystals

Microseeding could be potential method for overcoming hemihedral twinning in protein crystals

Twinning is a crystal-growth disorder in which the specimen is composed of distinct domains whose orientations differ but are related in a particular, well-defined way. [More]
UT Southwestern researchers develop new imaging method to see proteins in action

UT Southwestern researchers develop new imaging method to see proteins in action

UT Southwestern Medical Center researchers developed a new imaging technique that makes X-ray images of proteins as they move in response to electric field pulses. [More]
New study may shed light on diseases associated with mutations in aminoacyl tRNA synthetases

New study may shed light on diseases associated with mutations in aminoacyl tRNA synthetases

New research led by scientists at The Scripps Research Institute reveals that a human enzyme has changed little from its days as a bacterial enzyme. In fact, the enzyme appears to be unique in its ability to change its shape—and its job in cells—without overhauling its basic architecture. [More]
Biochemists uncover how potential diabetes drugs interact with LRH-1 protein

Biochemists uncover how potential diabetes drugs interact with LRH-1 protein

Imagine a key that opens a pin tumbler lock. A very similar key can also fit into the lock, but upside down in comparison to the first key. [More]
Scientists synthesize antitumor compound to combat chemoresistant cancer

Scientists synthesize antitumor compound to combat chemoresistant cancer

A team of scientists from N. D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, N. K. Kol'tsov Institute of Developmental Biology of the RAS, and Immune Pharmaceuticals LLC led by MIPT's Prof. Alexander Kiselyov has synthesized an antitumor compound that could be used to fight chemoresistant cancer. [More]
Tiny, glowing crystals could be powerful new tool to detect and clean contaminated water sources

Tiny, glowing crystals could be powerful new tool to detect and clean contaminated water sources

Tiny, glowing crystals designed to detect and capture heavy-metal toxins such as lead and mercury could prove to be a powerful new tool in locating and cleaning up contaminated water sources. [More]
Study shows power of haptic interfaces, web computing to create shareable scientific environment in crystallography

Study shows power of haptic interfaces, web computing to create shareable scientific environment in crystallography

Haptic interfaces have been readily adopted because of their intuitive ease of use and convenience. [More]
Study highlights potential to develop antiviral therapies, vaccines for treating astroviruses

Study highlights potential to develop antiviral therapies, vaccines for treating astroviruses

Human astroviruses infect nearly everyone during childhood, causing diarrhea, vomiting, and fever. [More]
TSRI scientists offer novel structure-based drug design strategy for better breast cancer treatment

TSRI scientists offer novel structure-based drug design strategy for better breast cancer treatment

While there have been advances in the treatment of hormone-driven breast cancer, resistance to these therapies remains a significant problem. [More]
Study shows how Zika virus infection leads to production of smaller disease-causing RNAs

Study shows how Zika virus infection leads to production of smaller disease-causing RNAs

Researchers, led by scientists at the University of Colorado School of Medicine, have found basic molecular processes used by the Zika virus to "hijack" the cells that it infects and potentially how it makes molecules that are directly linked to disease. [More]
Researchers lay foundation for improved TB treatment by targeting new enzyme

Researchers lay foundation for improved TB treatment by targeting new enzyme

Researchers at Johns Hopkins report they have laid the foundation to develop novel antibiotics that work against incurable, antibiotic-resistant bacteria like tuberculosis by targeting an enzyme essential to the production and integrity of bacterial cell walls. [More]
Scientists unravel viral molecular strategies to counter mammalian immune system

Scientists unravel viral molecular strategies to counter mammalian immune system

As mammals evolve, so do mammalian viruses. In doing so, they develop creative and effective ways to counter and evade the antiviral responses of their mammal hosts' immune systems. [More]
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