Cytokine News and Research

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Human lung airway-on-a-chip faithfully recapitulates cystic fibrosis pathology

The inherited progressive disorder cystic fibrosis (CF) causes severe damage to the lungs, and other tissues in the body by affecting the cells that produce mucus, sweat, and digestive juices.

21 Nov 2021

Comparing effectiveness of virus and patients-centered strategies to reduce COVID-19 mortality

Researchers from Sorbonne Université have been reviewing papers exploring different anti-COVID-19 drugs.

19 Nov 2021

Severe COVID-19 patients have significantly higher NK and T cell frequency

A new study published in the open-access journal Cells aimed to clarify the role of NK and T cell subsets in SARS-CoV-2 infection in hospitalized COVID-19 patients to unravel their potential association with disease severity.

18 Nov 2021

Tea and coffee consumption associated with lower risk of stroke and dementia

Researchers investigate the impact of coffee and tea separately and in combination on the risk of stroke and dementia.

18 Nov 2021

Researchers receive $22 million grant for clinical trial that aims to reduce lung transplant rejection

Physicians at Washington University School of Medicine in St. Louis and Massachusetts General Hospital/Harvard Medical School in Boston have received a seven-year, $22 million grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health to help lead a multicenter clinical trial evaluating whether a novel immunosuppressant can reduce the risk of organ rejection after a lung transplant.

18 Nov 2021

NIH study finds naturally acquired immunity is weak against SARS-CoV-2 variants

Immunity acquired after recovering from SARS-CoV-2 infection is not sufficient in protecting against reinfection from variants.

18 Nov 2021

Triad of cytokines associated with long COVID

A new study suggests a trio of cytokines — IL-1ß, IL-6, and TNF-α — are associated with long COVID symptoms.

18 Nov 2021

Blood proteomic survey in undiagnosed population with COVID-19

In this study, scientists have profiled 276 circulating proteins that are associated with cardiovascular and metabolic functions.

18 Nov 2021

Toll-like receptor 2 - novel target for improved COVID-19 vaccines

In a new study, researchers from French and American institutes analyzed at a molecular level the interaction between SARS-CoV-2 E protein and human TLR2.

17 Nov 2021

The antiviral function of BET protein against SARS-CoV-2 infection

Considering the past shreds of evidence on BRD2 and BRD4 associated with viral infections, researchers have recently evaluated the function of all relevant BET proteins during COVID-19 infection.

17 Nov 2021

Model simulations show no need for DEX dose adjustments in COVID-19 patients with liver disease

A recent study sed PBPK modeling to demonstrate the use of DEX PKs for the treatment of COVID-19 in patients with liver impairment.

17 Nov 2021

Clinically applicable strategy for early identification of IFN-AAB-positive COVID-19 patients

Researchers from the Humboldt-Universität zu Berlin have been investigating the presence of these antibodies in hospitalized COVID-19 patients to examine the potential of using them as a biomarker for severe disease.

17 Nov 2021

A therapeutic interfering particle for SARS-CoV-2

Researchers report their attempt to engineer TIPs that can conditionally replicate with SARS-CoV-2, inhibit viral replication 10–100 fold, and exhibit R0>1.

16 Nov 2021

SARS-CoV-2 replicates in human placenta with release of infectious viral particles

The current study analyzed the interaction of SARS-CoV-2 at the human maternal-fetal interface by using an advanced ex vivo model.

16 Nov 2021

Deficient spike-specific T cell responses and inability to neutralize SARS-CoV-2 variants 12 month post-infection

Researchers conducted a comprehensive, longitudinal, long-term immune study, including functional assays to assess immune fitness against antigenically different VoC. The study is currently available on the preprint server medRxiv* while awaiting peer review.

15 Nov 2021

Study analyzes association between obesity and endothelial dysfunction in COVID-19 patients

In COVID-19 patients, obesity is the factor most associated with the development of endothelial dysfunction, a condition in which the blood vessels become unable to contract and relax adequately, increasing the risk of events such as heart attacks, thrombosis (blood clotting), and stroke.

15 Nov 2021

Cytokine News and Research

Human lung airway-on-a-chip faithfully recapitulates cystic fibrosis pathology

Comparing effectiveness of virus and patients-centered strategies to reduce COVID-19 mortality

Severe COVID-19 patients have significantly higher NK and T cell frequency

Tea and coffee consumption associated with lower risk of stroke and dementia

Researchers receive $22 million grant for clinical trial that aims to reduce lung transplant rejection

NIH study finds naturally acquired immunity is weak against SARS-CoV-2 variants

Triad of cytokines associated with long COVID

Blood proteomic survey in undiagnosed population with COVID-19

Toll-like receptor 2 - novel target for improved COVID-19 vaccines

The antiviral function of BET protein against SARS-CoV-2 infection

Model simulations show no need for DEX dose adjustments in COVID-19 patients with liver disease

Clinically applicable strategy for early identification of IFN-AAB-positive COVID-19 patients

A therapeutic interfering particle for SARS-CoV-2

SARS-CoV-2 replicates in human placenta with release of infectious viral particles

Deficient spike-specific T cell responses and inability to neutralize SARS-CoV-2 variants 12 month post-infection

Study analyzes association between obesity and endothelial dysfunction in COVID-19 patients

Histone mimicry as a mechanism through which SARS-CoV-2 disrupts host cell epigenetic regulation

Study identifies a host factor that reflects different levels of inflammation within mild COVID-19 cases

Could drugs derived from microalgae be effective against COVID-19?

SARS-CoV-2 infection inhibited by CCR2 signaling

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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