Cytokine News and Research

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How SARS-CoV-2 spike binds to multiple host receptors

Researchers from the Genos Glycoscience Research Laboratory in Croatia have recently investigated the sites that the S protein is capable of binding with.

23 Sep 2021

COVID-19 transmission is higher with warm weather and increased visits to indoors public places, study finds

A new study finds that environmental factors and human mobility predict seasonal changes in COVID-19 rates, just as in influenza and similar diseases.

23 Sep 2021

Varying immune responses after single dose of Pfizer and AstraZeneca COVID-19 vaccines

A new preprint describes the significant variation in the early immune response elicited by two of the earliest vaccines to gain emergency authorization against COVID-19.

23 Sep 2021

The impact of multiple sclerosis therapy on COVID-19 vaccine efficacy

In a paper, the vaccine-induced cellular and immune response of MS patients receiving a range of therapies are assessed.

23 Sep 2021

McLean wins NIH grant to explore links between COVID-19 vaccine and menstrual cycle changes

In research that will add important data to the experience of vaccines on women's health, Laura Payne, PhD, director of McLean Hospital's Clinical and Translational Pain Research Laboratory, has received a grant from the National Institutes of Health to explore potential links between SARS-CoV-2 vaccination and menstrual cycle changes.

23 Sep 2021

COVID-19 deaths in U.S. surpass 1918 Spanish Flu pandemic

The coronavirus disease (COVID-19) pandemic is most likely the deadliest outbreak in recent American history, exceeding the estimated deaths from the 1918 influenza pandemic.

21 Sep 2021

High-fat diet or genetically induced obesity can lead to loss of hair follicles

It's well known that obesity is linked to the development of numerous diseases in humans. Heart disease, diabetes, and other ailments are extremely common in obese individuals.

21 Sep 2021

Implications of dosing sparing and booster shots in the context of prior SARS-CoV-2 infection

The current study suggests that deferring the second vaccination of individuals with prior infection may be a cost-effective strategy.

21 Sep 2021

Scientists identify potential therapeutic targets to alleviate severe COVID-19 in aged patients

The scientists assessed epidemiological data from March to December 2020 from the CDC to investigate the prevalence of COVID-19 disease among different age groups.

21 Sep 2021

Decline in SARS-CoV-2 neutralizing antibodies and unique cytokine profile in severe COVID-19 patients

A new study has focused on antibody levels and cytokine profiles of COVID-19 patients with mild symptoms, pneumonia, and severe pneumonia.

21 Sep 2021

Neurokinin-1 receptor: a potential drug target for the treatment of COVID-19

An opinion article aims to provide evidence that SP could be the possible factor for initiating the cytokine storm during severe SARS-CoV-2 infection.

21 Sep 2021

Dynamics of innate immune responses decide COVID-19 severity in genetically diverse mice

In a recently published article on the bioRxiv* preprint server, scientists from the USA and UK have described the significance of early inflammatory signaling pathways in determining the severity of coronavirus disease 2019 (COVID-19).

21 Sep 2021

Researchers identify prediction markers which can be used to define COVID-19 severity

An estimated 14−17% of hospitalized COVID-19 patients develop a severe form of the disease, requiring oxygen support and admission to the intensive care unit.

20 Sep 2021

SARS-CoV-2 NSP1 protein suppresses host genes while enhancing viral RNA expression

In a recent study, researchers study the molecular aspects of SARS-CoV-2 host cell entry and inhibition of host-specific cellular mechanisms.

20 Sep 2021

T cell immunity induced after mild COVID could contribute to protection against re-infection

An interesting new study finds that in both adults and children, a mild infection with the SARS-CoV-2 elicits an antigen-specific memory T-cell response.

20 Sep 2021

Research on SARS-CoV-2 and dendritic cells may explain why virus is so virulent

In a recent study released on the bioRxiv* preprint server, the researchers suggest that an aberrant inflammatory reaction associated with COVID-19 could be a result of escape from direct sensing by toll-like receptors (TLRs). Moreover, the researchers indicate that this phenomenon might underlie the lack of efficient immunity to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early during infection.

20 Sep 2021

Fatal COVID-19 infections linked to poor immune responses and elevated MAIT cell activation

The mortality rate of COVID-19 patients requiring mechanical ventilation is 30-40%, however, the immunological factors associated with death in critically ill COVID-19 patients are poorly understood.

16 Sep 2021

Pfizer vaccine induces strong immunity in elderly with prior COVID-19

A new study discusses the vaccination response in elderly who were vaccinated with one dose of the Pfizer vaccine 15 months after contracting COVID-19.

16 Sep 2021

Analysis of the immune landscape in mild-to-moderate COVID-19

A new study includes an analysis of plasma cytokine levels, peripheral blood immune cell composition, and SARS-CoV-2 specific Igs in COVID-19.

15 Sep 2021

Deep profiling of SARS-CoV-2 immune response amongst the mildly symptomatic

In a research paper recently uploaded to the medRxiv* preprint server by Capelle et al. (September 2nd, 2021), the immune response of mild and hospitalized COVID-19 patients is compared, finding that early T-cell response is a vital indicator of SARS-CoV-2 disease severity.

15 Sep 2021

Cytokine News and Research

How SARS-CoV-2 spike binds to multiple host receptors

COVID-19 transmission is higher with warm weather and increased visits to indoors public places, study finds

Varying immune responses after single dose of Pfizer and AstraZeneca COVID-19 vaccines

The impact of multiple sclerosis therapy on COVID-19 vaccine efficacy

McLean wins NIH grant to explore links between COVID-19 vaccine and menstrual cycle changes

COVID-19 deaths in U.S. surpass 1918 Spanish Flu pandemic

High-fat diet or genetically induced obesity can lead to loss of hair follicles

Implications of dosing sparing and booster shots in the context of prior SARS-CoV-2 infection

Scientists identify potential therapeutic targets to alleviate severe COVID-19 in aged patients

Decline in SARS-CoV-2 neutralizing antibodies and unique cytokine profile in severe COVID-19 patients

Neurokinin-1 receptor: a potential drug target for the treatment of COVID-19

Dynamics of innate immune responses decide COVID-19 severity in genetically diverse mice

Researchers identify prediction markers which can be used to define COVID-19 severity

SARS-CoV-2 NSP1 protein suppresses host genes while enhancing viral RNA expression

T cell immunity induced after mild COVID could contribute to protection against re-infection

Research on SARS-CoV-2 and dendritic cells may explain why virus is so virulent

Fatal COVID-19 infections linked to poor immune responses and elevated MAIT cell activation

Pfizer vaccine induces strong immunity in elderly with prior COVID-19

Analysis of the immune landscape in mild-to-moderate COVID-19

Deep profiling of SARS-CoV-2 immune response amongst the mildly symptomatic

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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