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Researchers identify prediction markers which can be used to define COVID-19 severity

An estimated 14−17% of hospitalized COVID-19 patients develop a severe form of the disease, requiring oxygen support and admission to the intensive care unit.

20 Sep 2021

SARS-CoV-2 NSP1 protein suppresses host genes while enhancing viral RNA expression

In a recent study, researchers study the molecular aspects of SARS-CoV-2 host cell entry and inhibition of host-specific cellular mechanisms.

20 Sep 2021

T cell immunity induced after mild COVID could contribute to protection against re-infection

An interesting new study finds that in both adults and children, a mild infection with the SARS-CoV-2 elicits an antigen-specific memory T-cell response.

20 Sep 2021

Research on SARS-CoV-2 and dendritic cells may explain why virus is so virulent

In a recent study released on the bioRxiv* preprint server, the researchers suggest that an aberrant inflammatory reaction associated with COVID-19 could be a result of escape from direct sensing by toll-like receptors (TLRs). Moreover, the researchers indicate that this phenomenon might underlie the lack of efficient immunity to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early during infection.

20 Sep 2021

Fatal COVID-19 infections linked to poor immune responses and elevated MAIT cell activation

The mortality rate of COVID-19 patients requiring mechanical ventilation is 30-40%, however, the immunological factors associated with death in critically ill COVID-19 patients are poorly understood.

16 Sep 2021

Pfizer vaccine induces strong immunity in elderly with prior COVID-19

A new study discusses the vaccination response in elderly who were vaccinated with one dose of the Pfizer vaccine 15 months after contracting COVID-19.

16 Sep 2021

Analysis of the immune landscape in mild-to-moderate COVID-19

A new study includes an analysis of plasma cytokine levels, peripheral blood immune cell composition, and SARS-CoV-2 specific Igs in COVID-19.

15 Sep 2021

Deep profiling of SARS-CoV-2 immune response amongst the mildly symptomatic

In a research paper recently uploaded to the medRxiv* preprint server by Capelle et al. (September 2nd, 2021), the immune response of mild and hospitalized COVID-19 patients is compared, finding that early T-cell response is a vital indicator of SARS-CoV-2 disease severity.

15 Sep 2021

Flu shots and COVID-19 immunity

A new paper finds that the influenza vaccine may influence both the response to and incidence of infection by the SARS-CoV-2.

14 Sep 2021

Severe COVID-19 linked to increase in autoantibodies

Hospitalized COVID-19 patients are substantially more likely to harbor autoantibodies -;antibodies directed at their own tissues or at substances their immune cells secrete into the blood -; than people without COVID-19, according to a new study.

14 Sep 2021

Researchers explore whether cocoa supplementation can reduce aging

Whether consuming cocoa, known to be packed with powerful antioxidants that protect our cells from damage, helps us age better, is a question scientists want to definitively answer.

14 Sep 2021

Metabolic and immune markers as tools for risk stratification and monitoring in COVID-19

In a new study posted to the medRxiv* server scientists from Weil Cornell University and Stony Brook University in New York attempted to identify the metabolic and immune markers associated with severe COVID-19 disease using high-throughput targeted nuclear magnetic resonance (NMR) spectroscopy and high-dimensional flow cytometry. This will facilitate risk stratification, monitoring, and therapeutic interventions in COVID-19 patients.

14 Sep 2021

A review of mesenchymal stem cell therapy for severe COVID-19

Researchers find that MSC treatment is highly tolerated and effective in reducing lung damage in COVID-19 patients and improving their chances of recovery.

13 Sep 2021

Age-related differences in immune dynamics in rhesus macaques infected with SARS-CoV-2

In a recent study, authors explore the relationship between age and immune response to COVID-19.

13 Sep 2021

COVID-19 vaccine antibodies inversely related to BMI in obese men, but not women

A new study discusses the role of obesity in COVID-19 and its role in antibody-mediated immune responses to the COVID-19 vaccine.

7 Sep 2021

A study of 105 protective and risk factors related to the incidence and severity of COVID-19

A recent study discusses both the known and unknown factors that may affect the risk of infection with SARS-CoV-2 and a severe course of COVID-19.

7 Sep 2021

Severe COVID-19 is associated with expansion of immature myeloid cells and inflammation

A team of scientists in Ireland recently identified certain immune markers that can predict the progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to severe coronavirus disease 2019 (COVID-19). Early detection of these predictive markers can facilitate therapeutic decision-making prior to peak severity.

7 Sep 2021

Simple and rapid method measures T-cell immune response to SARS-CoV-2 virus

Researchers from Duke-NUS Medical School, together with collaborators from the National Centre for Infectious Diseases (NCID) and Singapore General Hospital (SGH), have discovered a simple and rapid method to measure the T-cell immune response to the SARS-CoV-2 virus, which causes COVID-19.

3 Sep 2021

Research uncovers test to identify iMCD patients with superior response to FDA-approved treatment

New research has uncovered a precision medicine test using blood proteins to identify a novel patient subgroup of idiopathic multicentric Castleman disease (iMCD), a rare blood disorder, who are more likely to respond to siltuximab, the only FDA approved treatment for the disease.

2 Sep 2021

Study shows bacille Calmette-Guérin vaccine can protect mice against lethal SARS-CoV-2 challenge

A recent US study, currently available on bioRxiv* preprint server, implies that vaccination with bacille Calmette-Guérin (BCG) can limit the infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by targeting innate immune pathways and could thus be used as a platform for pinpointing early immunologic events affecting the outcome of coronavirus disease (COVID-19).

1 Sep 2021

Cytokine News and Research

Researchers identify prediction markers which can be used to define COVID-19 severity

SARS-CoV-2 NSP1 protein suppresses host genes while enhancing viral RNA expression

T cell immunity induced after mild COVID could contribute to protection against re-infection

Research on SARS-CoV-2 and dendritic cells may explain why virus is so virulent

Fatal COVID-19 infections linked to poor immune responses and elevated MAIT cell activation

Pfizer vaccine induces strong immunity in elderly with prior COVID-19

Analysis of the immune landscape in mild-to-moderate COVID-19

Deep profiling of SARS-CoV-2 immune response amongst the mildly symptomatic

Flu shots and COVID-19 immunity

Severe COVID-19 linked to increase in autoantibodies

Researchers explore whether cocoa supplementation can reduce aging

Metabolic and immune markers as tools for risk stratification and monitoring in COVID-19

A review of mesenchymal stem cell therapy for severe COVID-19

Age-related differences in immune dynamics in rhesus macaques infected with SARS-CoV-2

COVID-19 vaccine antibodies inversely related to BMI in obese men, but not women

A study of 105 protective and risk factors related to the incidence and severity of COVID-19

Severe COVID-19 is associated with expansion of immature myeloid cells and inflammation

Simple and rapid method measures T-cell immune response to SARS-CoV-2 virus

Research uncovers test to identify iMCD patients with superior response to FDA-approved treatment

Study shows bacille Calmette-Guérin vaccine can protect mice against lethal SARS-CoV-2 challenge

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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