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Cytomegalovirus (CMV) is a member of the herpes virus group, which includes herpes simplex virus types 1 and 2, varicella-zoster virus (which causes chickenpox), and Epstein-Barr virus (which causes infectious mononucleosis). Infection with CMV is a major cause of disease and death in immunocompromised patients, including organ transplant recipients, patients undergoing hemodialysis, patients with cancer, patients receiving immunosuppressive drugs, and HIV-infected patients. While drugs are available for treatment of these conditions, the primary drug choices carry significant side effects and warnings. Currently, there are no anti-CMV drugs indicated for treatment of primary CMV infection during pregnancy resulting in infections that can have catastrophic consequences to the newborn. Maternal-fetal transfer of CMV infection results in a fetal death rate of 12% and most survivors have permanent debilitating disorders, including mental retardation, vision loss, and sensorineural deafness.
UNMC researcher aims to find workable solution for tackling antibiotic resistance

UNMC researcher aims to find workable solution for tackling antibiotic resistance

Sam Sanderson, Ph.D., a research associate professor in the UNMC College of Pharmacy, recently secured an R01 grant from the National Institutes of Health to find a workable solution to the problem of antibiotic resistance. [More]
HHV-6A human herpesvirus infects uterus lining of women with unexplained infertility

HHV-6A human herpesvirus infects uterus lining of women with unexplained infertility

A new study has found that the little-known member of the human herpesvirus family called HHV-6A infects the lining of the uterus in 43% of women with unexplained infertility but cannot be found in uterine lining of fertile women. The study was conducted by investigators at the University of Ferrara, Italy. [More]
Study highlights role of CMV in patients with leukemia after bone marrow transplantation

Study highlights role of CMV in patients with leukemia after bone marrow transplantation

Recent studies on a small number of patients with leukemia treated with bone marrow transplantation have suggested that the presence of the common cytomegalovirus (CMV) in patients or their donors may protect against relapse or even death after the transplant. [More]
Disrupted fetal immune system increases later risk of neurodevelopmental diseases

Disrupted fetal immune system increases later risk of neurodevelopmental diseases

Disrupted fetal immune system development, such as that caused by viral infection in the mother, may be a key factor in the later appearance of certain neurodevelopmental disorders. [More]
T memory cells with naive phenotype can help boost immunity in older adults

T memory cells with naive phenotype can help boost immunity in older adults

Sixty-five is the age when many people retire, kick back and take it easy. And so it often is with the human immune system. [More]
New study identifies PDGFRα as key molecule for HCMV viral entry

New study identifies PDGFRα as key molecule for HCMV viral entry

A publication in the scientific journal Nature Microbiology identifies PDGFRα as the receptor for the trimeric gHgLgO complex of Human cytomegalovirus (HCMV). [More]
Positive effects of Mediterranean diet on health of elderly population

Positive effects of Mediterranean diet on health of elderly population

Sticking to a Mediterranean style diet might slow down ageing finds the EU funded project NU-AGE. At a recent conference in Brussels, researchers presented that a NU-AGE Mediterranean style diet, tested in the project, significantly decreased the levels of the protein known as C-reactive protein, one of the main inflammatory marker linked with the ageing process [More]
New study to explore outcomes of pregnancy in Brazilian women with Zika virus

New study to explore outcomes of pregnancy in Brazilian women with Zika virus

An observational study of pregnant women in Brazil to further understand Zika virus and its impact on reproductive health and fetus development have been launched. William Britt, M.D., professor of pediatric infectious diseases at the University of Alabama at Birmingham, leads the study, which complements his current research in Brazil on cytomegalovirus infection during pregnancy. [More]
NAU researcher calls for greater public awareness of cytomegalovirus

NAU researcher calls for greater public awareness of cytomegalovirus

As the Zika virus continues to spread across the globe, and gain worldwide attention for its' potential birth defects, an NAU researcher is calling for greater public awareness of cytomegalovirus—the most common viral cause of birth defects in the United States. [More]
CMV-based vaccine provides protection against Ebola virus

CMV-based vaccine provides protection against Ebola virus

As the latest in a series of studies, researchers at Plymouth University, National Institutes of Health and University of California, Riverside, have shown the ability of a vaccine vector based on a common herpesvirus called cytomegalovirus (CMV) expressing Ebola virus glycoprotein (GP), to provide protection against Ebola virus in the experimental rhesus macaque, non-human primate (NHP) model. [More]
Roche's cobas HIV-1 viral load test approved by FDA for use on cobas 6800 and cobas 8800 Systems

Roche's cobas HIV-1 viral load test approved by FDA for use on cobas 6800 and cobas 8800 Systems

Roche announced today that it has received FDA approval for the cobas HIV-1 viral load test by the United States Food and Drug Administration for use on the cobas 6800 and cobas 8800 Systems. This HIV-1 viral load test is part of the next generation of Roche viral load tests, which clinicians use to manage the disease and treatment of patients infected with HIV-1. [More]
Self-disseminating vaccines could prevent EID transmission from animals to humans

Self-disseminating vaccines could prevent EID transmission from animals to humans

The 2014/2015 Ebola outbreak in West Africa shone the spotlight not only on the unpreparedness of local health services and science to deal with the pandemic, but also on the phenomenon of emerging infectious diseases (EIDs). [More]
First primate model can help researchers to study mother-to-fetus CMV infections

First primate model can help researchers to study mother-to-fetus CMV infections

Cytomegalovirus (CMV) is the leading infectious cause of birth defects worldwide, but scientists have been frustrated in their efforts to develop a vaccine to protect against infections. [More]
FDA permits marketing of first CSF nucleic acid-based test for detection of multiple pathogens

FDA permits marketing of first CSF nucleic acid-based test for detection of multiple pathogens

The U.S. Food and Drug Administration today allowed marketing of the first cerebrospinal fluid (CSF) nucleic acid-based test for simultaneous detection of multiple pathogens that can cause central nervous system infections. [More]
Donor and patient age more important in determining kidney transplant success

Donor and patient age more important in determining kidney transplant success

Infection by virus cytomegalovirus (CMV) is a common and major complication following kidney transplantation. Previous studies have related CMV infection with increased kidney transplant failure and reduced patient survival. However, a new study published in the American Journal of Physiology—Renal Physiology reports that the age of the donor and the recipient, not CMV infection, are more important factors in determining transplant success. [More]
Reducing amyloid fibril levels in semen may help reduce transmission of HIV

Reducing amyloid fibril levels in semen may help reduce transmission of HIV

There may be two new ways to fight AIDS -- using a heat shock protein or a small molecule - to attack fibrils in semen associated with the human immunodeficiency virus (HIV) during the initial phases of infection, according to new research from the Perelman School of Medicine at the University of Pennsylvania. [More]
Study: Chickenpox vaccination increases incidence of shingles in younger adults

Study: Chickenpox vaccination increases incidence of shingles in younger adults

Vaccinating one-year-olds against chickenpox could temporarily nearly double the incidence of shingles in the wider population, but in younger adults than previously thought. [More]
Antiva raises $16 million in Series B financing to advance antiviral compound through Phase 1 clinical trials

Antiva raises $16 million in Series B financing to advance antiviral compound through Phase 1 clinical trials

Antiva Biosciences, Inc. (formerly Hera Therapeutics), a biopharmaceutical company developing antiviral therapeutics, today announced that it has raised $16 million in a Series B financing, its first institutional round. [More]
Latent CMV infection induces telomere shortening

Latent CMV infection induces telomere shortening

The telomeres are repetitive DNA sequences at each end of our chromosomes. Studies show that in every cell division, the telomere is shortened. As a result, the telomere limits the cell to a fixed number of divisions and a limited life span. An essential part of human cells they affect how our cells age - as people with longer telomeres live longer lives. Surprisingly, people who are infected with a latent virus, that is, an asymptomatic virus, have shorter telomeres. [More]
Beckman Coulter brings new thinking to new lab challenges at EuroMedLab 2015

Beckman Coulter brings new thinking to new lab challenges at EuroMedLab 2015

Beckman Coulter Diagnostics supports IFCC-EFLM EuroMedLab 2015 with a showcase of solutions to improve workflow for the diagnostics laboratory. Held from 22-24 June 2015 at the Paris Palais des Congrès France, the company demonstrates its dedication to moving the clinical diagnostic lab forward with its total laboratory solution—from automation, chemistry, immunoassay and haematology to microbiology and its new molecular diagnostics system. [More]
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