Cytomegalovirus News and Research

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Cytomegalovirus (CMV) is a member of the herpes virus group, which includes herpes simplex virus types 1 and 2, varicella-zoster virus (which causes chickenpox), and Epstein-Barr virus (which causes infectious mononucleosis). Infection with CMV is a major cause of disease and death in immunocompromised patients, including organ transplant recipients, patients undergoing hemodialysis, patients with cancer, patients receiving immunosuppressive drugs, and HIV-infected patients. While drugs are available for treatment of these conditions, the primary drug choices carry significant side effects and warnings. Currently, there are no anti-CMV drugs indicated for treatment of primary CMV infection during pregnancy resulting in infections that can have catastrophic consequences to the newborn. Maternal-fetal transfer of CMV infection results in a fetal death rate of 12% and most survivors have permanent debilitating disorders, including mental retardation, vision loss, and sensorineural deafness.

Further Reading

Study provides insights into how HCMV infection causes birth defects

Study provides insights into how HCMV infection causes birth defects

Research findings identify protein as potential new drug target for HCMV infections

Research findings identify protein as potential new drug target for HCMV infections

New model may provide vital insights into life-saving treatment for CMV infection

New model may provide vital insights into life-saving treatment for CMV infection

Vaccine-chemotherapy combination may improve survival for glioblastoma patients

Vaccine-chemotherapy combination may improve survival for glioblastoma patients

Scientists shed light on evolutionary arms race between CMV and immune system

Scientists shed light on evolutionary arms race between CMV and immune system

Young researchers explore impact of prolonged Zika viremia in pregnant women, fetuses and infants

Young researchers explore impact of prolonged Zika viremia in pregnant women, fetuses and infants

Johns Hopkins researchers find no evidence of CMV in aggressive brain cancer tissues

Johns Hopkins researchers find no evidence of CMV in aggressive brain cancer tissues

Genetic variation may be reason for overreaction of immune system to viruses

Genetic variation may be reason for overreaction of immune system to viruses

Novel antiviral drug can protect transplant patients against CMV infections

Novel antiviral drug can protect transplant patients against CMV infections

Utah law increases early identification of infants with hearing loss, new study reveals

Utah law increases early identification of infants with hearing loss, new study reveals

Penn State researchers develop novel compound to combat cytomegalovirus

Penn State researchers develop novel compound to combat cytomegalovirus

Genetic mutation may increase susceptibility to cytomegalovirus infection

Genetic mutation may increase susceptibility to cytomegalovirus infection

Newborns with CMV may have increased risk of developing acute lymphocytic leukemia

Newborns with CMV may have increased risk of developing acute lymphocytic leukemia

Japanese researchers discover new method for predicting congenital CMV infection in fetuses

Japanese researchers discover new method for predicting congenital CMV infection in fetuses

Congenital CMV infection highly common among children with cerebral palsy, study finds

Congenital CMV infection highly common among children with cerebral palsy, study finds

Researchers develop new way to prevent diseases caused by herpesvirus infections

Researchers develop new way to prevent diseases caused by herpesvirus infections

Researchers develop new way to test strength of immune response

Researchers develop new way to test strength of immune response

Study provides potential new target to combat cytomegalovirus infections

Study provides potential new target to combat cytomegalovirus infections

First case-control study examines link between microcephaly and in utero Zika virus infection

First case-control study examines link between microcephaly and in utero Zika virus infection

Malformations in the brains of fetuses caused by Zika virus go beyond microcephaly

Malformations in the brains of fetuses caused by Zika virus go beyond microcephaly