Demyelination News and Research

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A demyelinating disease is any disease of the nervous system in which the myelin sheath of neurons is damaged. This impairs the conduction of signals in the affected nerves, causing impairment in sensation, movement, cognition, or other functions depending on which nerves are involved.

Dartmouth research unlocks extended cell death pathway in aging brain cells

For oligodendrocytes-;the central nervous system cells critical for brain function-;age may not bring wisdom, but it does come with the power to cling to life for much, much longer than scientists knew.

28 Mar 2024

Study highlights potential therapeutic target for immune-related disorders

A new study highlights a potential therapeutic target for immune-related disorders, such as multiple sclerosis and asthma.

11 Mar 2024

Noninvasive gamma therapy may hold promise for treating chemo brain

Patients undergoing chemotherapy often experience cognitive effects such as memory impairment and difficulty concentrating -; a condition commonly known as "chemo brain."

6 Mar 2024

Cytokine interferon-gamma can be a disease-modifying therapeutic target in multiple system atrophy

Multiple system atrophy is a rare and fatal neurodegenerative disease, where insoluble inclusions of the protein alpha-synuclein appear in oligodendrocyte cells of the brain.

12 Feb 2024

Widespread pain makes exercise a challenge for some patients with multiple sclerosis

For patients with multiple sclerosis, a regular exercise routine is important for managing symptoms. Due to different causes of chronic pain though, physical exercise can be more difficult for some.

10 Jan 2024

Abnormal myelin, not loss of myelin, may drive axon degeneration in myelin diseases

Myelin is an insulating sheath around axons - the processes connecting nerve cells - that is mostly composed of lipids and proteins.

28 Nov 2023

Dementia and cholesterol: investigating links and impacts of hormone replacement therapy

The relationships between hormone replacement therapy (HRT), serum cholesterol levels, and dementia incidence.

25 Oct 2023

Advanced neuroimaging reveals surprising link between glaucoma and Alzheimer's disease

The overlap in clinical and magnetic resonance imaging (MRI) findings between Alzheimer's disease and glaucoma.

9 Oct 2023

Exploring developmental pathways and disease interactions in nervous and stomatognathic systems

Scientists discuss the intricate relationship between the nervous and stomatognathic systems.

21 Aug 2023

Study examines unimodal vs multimodal neuroimaging methods for classifying psychosis

Scientists have analyzed recent evidence on the usefulness of single and multimodal neuroimaging techniques in characterizing psychotic disorders.

14 Aug 2023

Researchers discover possible new biomarker of MS-like autoimmune disease

It has been known for several years that the diagnosis "multiple sclerosis" conceals a whole range of different illnesses, each requiring customized treatment. Researchers at the University of Basel and the University Hospital of Basel have now described a possible new MS-like disease and explained how to diagnose it.

8 Aug 2023

Can vitamin D have positive effects on reducing cortical pathology, oxidative stress, and neurofilament light chain serum levels?

Researchers use an established murine model of cortical inflammatory demyelination to investigate the effects of vitamin D.

2 Aug 2023

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

Blood-brain barrier breakdown in multiple sclerosis leads to immune cell infiltration into the central nervous system. Antigen presentation at the barrier promotes CD8+ T cell entry, triggering focal breakdown and hindering their invasion.

4 Jun 2023

Cross-reactivity between Epstein-Barr virus and protein in multiple sclerosis sheds light on disease development

Research uncovers the association between multiple sclerosis (MS) and antibody reactivity to specific amino acids in CRYAB, along with the increased risk when combined with high EBNA1 responses. The study provides evidence of antibody and T cell cross-reactivity between EBNA1 and CRYAB, highlighting the role of EBV adaptive immune responses in MS development.

21 May 2023

Research reveals a more effective treatment for multiple sclerosis patients

Degeneration of myelin, an insulating sheath required for rapid communication between nerve cells, and neuroinflammation are notable hallmarks of Multiple Sclerosis (MS) and related neurodegenerative disorders such as Alzheimer's disease or Huntington's disease that affect roughly 2.8 million people in the world.

21 Apr 2023

Criteria to assess for multiple sclerosis in adults may be insufficient for pediatric patients

Criteria used by neurologists to assess for multiple sclerosis (MS) in adults may fail to identify the illness in children with imaging suspicious for the disease, an oversight that could delay treatment of the disease at its earliest stages, according to a Rutgers study.

16 Mar 2023

An overview of COVID-19-associated neurological complications in children

Researchers review current literature to understand the association between COVID-19, neuroimaging, and neurological symptoms in children.

14 Mar 2023

U of A researcher one step closer to demonstrating the potential of brain molecule to halt MS

A University of Alberta researcher is one step closer to demonstrating the potential of a brain molecule called fractalkine to halt and even reverse the effects of multiple sclerosis and other neurodegenerative diseases.

1 Feb 2023

Pheno Therapeutics announces worldwide license from UCB to a novel program for neurodegenerative disease

Pheno Therapeutics Limited., a biotechnology company focused on the discovery and development of small molecule therapeutics that promote remyelination for the treatment of neurological diseases such as multiple sclerosis, announced today it has entered into an exclusive worldwide license agreement with UCB.

12 Jan 2023

The spectrum of SARS-CoV-2–related neurologic involvement among children and adolescents in 2021

Researchers explored the distribution of severe neurologic involvement in SARS-CoV-2 pediatric patients.

10 Nov 2022