Dendrimer News and Research

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Partners of Bacterial Vaginosis sufferers at increased risk of HIV

Starpharma Holdings Limited today commented on results of a study which showed that men were three times more likely to contract HIV from their female partners if the women also had bacterial vaginosis (BV) in the three months before the men became infected.

18 Jul 2011

Starpharma expands partnership with Eli Lilly

Starpharma Holdings Limited (ASX:SPL,OTCQX:SPHRY) today announced the signing of a collaborative research agreement with leading US pharmaceutical corporation Eli Lilly and Company.

29 Sep 2010

Flow-induced polymer translocation through narrow and patterned channels

An octopus-like polymer can "walk" along the wall of a narrow channel as it is pushed through by a solvent. Now research in The Journal of Chemical Physics, which is published by the American Institute of Physics, provides a theoretical model that compares the transport characteristics of straight- and branched-chain polymers in smooth channels as well as in channels whose walls interact with the polymer -- work that could aid in the development of carrier molecules for delivering drugs at a controlled rate in the body.

4 Aug 2010

New PEGylated Polylysine dendrimers: Benefits patients with cancer, HIV and lymphatic conditions

Monash Institute of Pharmaceutical Science researchers, in collaboration with the biotechnology company Starpharma Holdings Ltd have developed a new method to deliver medications that may benefit thousands of patients with particular types of cancer, HIV and lymphatic conditions world-wide.

15 Mar 2010

Starpharma Holdings, Eli Lilly sign new collaborative drug research and development agreement

Starpharma Holdings Limited today announced the signing of a new agreement with Eli Lilly and Company under which Starpharma's dendrimer drug delivery technology will be applied to enhance compounds in Lilly's human pharmaceutical portfolio.

2 Feb 2010

Magnetic nanoworms and nanocrystals deliver siRNA to tumors

Small pieces of nucleic acid known as short interfering RNAs, or siRNAs, can turn off the production of specific proteins, a property that makes them one of the more promising new classes of anticancer drugs in development. Indeed, at least two siRNA-based anticancer therapies, both delivered to tumors in nanoparticles, have begun human clinical trials.

23 Sep 2009

Carbon nanotubes continue to show promise in battle against cancer

Carbon nanotubes, one of the original engineered nanomaterials, also may prove to be among the most versatile, as numerous teams of investigators continue to develop novel nanotube-based therapeutic and diagnostic tools. Over the past month, three new research papers have highlighted the potential of nanotubes as weapons against cancer.

28 Jun 2009

First molecular-level numerical study of gene therapy

In a recent issue of The Journal of Chemical Physics , published by the American Institute of Physics (AIP), a group of researchers at the University of California, Berkeley and Los Alamos National Laboratory describe the first comprehensive, molecular-level numerical study of gene therapy.

29 Apr 2009

Dendrimers as synthetic gene vectors

29 Apr 2009

Nanoparticles deliver gene therapy, killing tumors

Given that cancer is ultimately a genetic disease, it has long been the hope of researchers to use gene therapy to attack tumors where they might be most susceptible.

26 Mar 2009

Biodegradable nanoprobe images new blood vessel growth

Angiogenesis, the growth of new blood vessels, plays a critical role in several chronic human diseases, including metastatic cancer. In fact, several new anticancer therapies are designed to starve tumors by shutting down angiogenesis, but the lack of a good assay for quantifying angiogenesis in the body has hampered the development of effective antiangiogenesis therapies.

18 Jan 2009

Starpharma's VivaGelR patent approved in Japan

Starpharma Holdings Limited today announced that one of its key patents relating to the use of dendrimers to protect against sexually transmitted infections has been approved in Japan.

29 Oct 2008

Dendrimers improve imaging with magnetic nanoparticles

Dendrimers are spherical polymer nanoparticles that have shown promise as targeted anticancer drug delivery vehicles. Iron oxide nanoparticles have already demonstrated the ability to image tumors and metastatic lesions.

20 May 2008

New nanoparticles for targeting tumors

As a wide variety of nanoparticles continue to demonstrate their ability to improve the delivery of imaging agents and drugs to tumors, nanoparticle researchers have turned their attention to the challenge of systematically determining how a given nanoparticle’s physical and chemical characteristics affect its ability to target tumors. Such data could provide drug developers with guidelines to help them select the most effective type of nanoparticle for a given therapeutic or imaging application.

28 Mar 2008

Preclinical antitumor efficacy evaluation of dendrimer-based methotrexate conjugates

Although a variety of nanoparticles continue to show promise for improving cancer imaging and therapy, regulators and drug developers are concerned that these delivery systems may prove difficult to manufacture on a consistent basis, which is key for any agent designed for use in humans.

3 Mar 2008

Nanoparticles may provide safe pain control on the battlefield

University of Michigan scientists have received a pilot grant of nearly $1.3 million from the Defense Advanced Research Projects Agency to test whether nanoparticles can solve a pressing problem in battle zones like Iraq: how to administer sustained, safe doses of the most effective painkillers to injured soldiers, long before they can reach expert medical help.

1 Aug 2007

U.S. trial of new microbicide for HIV prevention to be tested in young women

Nearly half of all people infected with HIV/AIDS are now women, the majority of whom contracted the disease through sexual intercourse with male partners.

10 Jul 2007

Multifunctional nanoparticle platforms for targeting and imaging cancer cells

There has been much recent interest in how nanotechnology will impact the field of medicine. Unfortunately, a number of promising nanostructured systems have turned out to be extremely toxic to humans, thus precluding their use in clinical applications and dashing hopes of an early success for the interdisciplinary field of nanobiotechnology.

21 Jun 2007

Nanoparticle-enabled peptide delivery triggers tumor regression

Cells possess a variety of ways of dealing with mutations that can cause them to grow uncontrollably and eventually form a tumor. The tumor suppressor gene p53 plays a critical role in these cancer prevention processes, largely by triggering a form a cell death known as apoptosis.

14 Jun 2007

Hybrid gold-dendrimer nanoparticles target and image tumors

Dendrimer nanoparticles, made of spherical, highly branched polymers, have shown promise as drug delivery vehicles capable of targeting tumors with large doses of anticancer drugs.

14 Jun 2007