Depressive Disorder News and Research

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Nightmare of insomnia could explain suicide link in patients with depression

The link between insomnia and suicidal thoughts in patients with depression may be mediated by nightmares and dysfunctional beliefs and attitudes about sleep, research suggests.

15 Feb 2013

Physical activity may reduce risk of depression in patients undergoing bariatric surgery

Adults undergoing bariatric surgery who are more physically active are less likely to have depressive symptoms and to have recently received medication or counseling for depression or anxiety than their less active counterparts, according to new research led by the University of Pittsburgh Graduate School of Public Health.

15 Feb 2013

Targacept reports net loss of $15.9 million for fourth quarter 2012

Targacept, Inc., a clinical-stage biopharmaceutical company developing novel NNR Therapeutics, today reported its financial results for the fourth quarter and year ended December 31, 2012.

14 Feb 2013

New insights on role of placebo in depression

A randomized controlled trial published in one of the last issue of Psychotherapy and Psychosomatics unravels new insights on the role of placebo in depression.

10 Feb 2013

Weekend reading: Mental health discrimination; A doctor faces hard questions; Long-term outlook for health care jobs

"When I had cancer, I got cards and flowers," Karen Kangas' sign reads. "When I was diagnosed with bipolar disorder, I got no cards and a pink slip." A picture of Kangas holding the sign hangs in the state Capitol complex, part of an exhibit called "Discrimination: A Roadblock to Recovery."

9 Feb 2013

Top-line results from Vanda's tasimelteon Phase IIb/III study on major depressive disorder

Vanda Pharmaceuticals Inc. today announced top-line results of the Phase IIb/III clinical study (MAGELLAN) in Major Depressive Disorder (MDD), investigating the efficacy and safety of tasimelteon as a monotherapy in the treatment of patients with MDD.

31 Jan 2013

Bipolar pedigree endophenotypes found

Researchers have found cognitive endophenotypes in a single extended family showing linkage of bipolar disorder to a risk locus on chromosome 4.

30 Jan 2013

Cerebrospinal fluid IL-6 increased in schizophrenia

Cerebrospinal fluid levels of interleukin-6 are significantly increased in patients with schizophrenia and major depressive disorder, Japanese study results show.

9 Jan 2013

Comorbid Axis I disorders highly prevalent in mood disorder patients

More than 80% of patients with mood disorders have at least one comorbid Axis I disorder, study results show.

3 Jan 2013

Naurex announces completion of $38M Series B financing

Naurex Inc., a clinical-stage company developing innovative treatments to address unmet needs in psychiatry and neurology, today announced the completion of a $38 million Series B financing led by new investor Baxter Ventures.

17 Dec 2012

Takeda, Lundbeck announce FDA acceptance of vortioxetine NDA submission

Takeda Global Research & Development Center, Inc., (Takeda) and H. Lundbeck A/S (Lundbeck) jointly announced today that the U.S. Food and Drug Administration (FDA) has accepted for filing their submission of a New Drug Application (NDA) for vortioxetine for the treatment of major depressive disorder (MDD) in adult patients.

13 Dec 2012

Cognitive behavioral therapy for anxiety-related dizziness

Patients with chronic subjective dizziness that is related to anxiety may substantially benefit from a short course of cognitive behavioral therapy, report researchers.

4 Dec 2012

Subthreshold bipolarity common in major depressive disorder

Results from a Polish study show that a substantial proportion of patients with major depressive disorder meet criteria for subthreshold bipolarity.

27 Nov 2012

Speed of depression onset increased in bipolar patients

Depressive episodes take significantly less time to develop in patients with bipolar disorder than in those with unipolar depression, German study findings confirm.

13 Nov 2012

Family history of schizophrenia ups risk for nonpsychotic disorders

Individuals with a family history of schizophrenia are at a significantly increased risk for a wide range of nonpsychotic DSM-IV axis I psychiatric disorders, US research shows.

8 Nov 2012

Reduced hedonic capacity in euthymic bipolar patients

Euthymic patients with bipolar disorder and remitted patients with major depressive disorder show reduced hedonic capacity compared with mentally healthy individuals, Italian researchers report.

8 Nov 2012

Family history of schizophrenia ups risk for nonpsychotic disorders

Individuals with a family history of schizophrenia are at a significantly increased risk for a wide range of nonpsychotic DSM-IV axis I psychiatric disorders, US research shows.

8 Nov 2012

Controlling depression can improve health status and social functioning in patients with heart failure

Controlling depression in patients with heart failure can improve health status, social functioning and quality of life, according to a new study by psychiatrists and cardiologists at the UC Davis and Duke University schools of medicine.

1 Nov 2012

Neuralstem initiates second cohort NSI-189 Phase Ib trial in major depressive disorder

Neuralstem, Inc. announced that it has begun dosing the second cohort of patients in its ongoing Phase Ib to test the safety of NSI-189 in the treatment of major depressive disorder (MDD).

19 Oct 2012

MDD with subthreshold hypomania ‘should be merged with bipolar II’

Patients with major depressive disorder plus subthreshold hypomania exhibit significant differences in disease course, symptoms, treatment-seeking rates, and other characteristics compared with those with major depression alone, research shows.

11 Oct 2012