Developmental Disorder News and Research

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Study shows how NCAN gene results in manic symptoms of bipolar disorder

Flying high, or down in the dumps - individuals suffering from bipolar disorder alternate between depressive and manic episodes. Researchers from the University of Bonn and the Central Institute of Mental Health in Mannheim have now discovered, based on patient data and animal models, how the NCAN gene results in the manic symptoms of bipolar disorder. The results have been published in the current issue of "The American Journal of Psychiatry."

1 Sep 2012

Utility of DMDD diagnosis in child psychiatric patients questioned

In children admitted to a psychiatric unit with serious behavioral problems, use of the new diagnosis concept of disruptive mood dysregulation disorder may go some way to reducing diagnoses of bipolar disorder, research shows.

10 Aug 2012

Kids with congenital heart defect should receive early evaluation for developmental disorders

Children born with a congenital heart defect should receive early evaluation, prompt treatment and ongoing follow-up for related developmental disorders affecting brain function, according to a new American Heart Association scientific statement published in Circulation.

31 Jul 2012

Study offers new clues for early autism diagnosis

A new study shows significant differences in brain development in high-risk infants who develop autism starting as early as age 6 months. The findings published in the American Journal of Psychiatry reveal that this abnormal brain development may be detected before the appearance of autism symptoms in an infant's first year of life. Autism is typically diagnosed around the age of 2 or 3.

28 Jun 2012

FDA grants Fast Track designation to Edimer’s EDI200 for treatment of XLHED

Edimer Pharmaceuticals, a biotechnology company focused on developing an innovative therapy for the rare genetic disorder, X-linked Hypohidrotic Ectodermal Dysplasia (XLHED), today announced the receipt of Fast Track designation from the U.S. Food and Drug Administration (FDA) for EDI200, the company's novel, proprietary, recombinant protein.

13 Jun 2012

Longer looks: The impossible quest to find out the cost of care; Toobin's tips on SCOTUS decision

When the nurse calls my name, I head up to the check-in desk. "I'm sorry," she says as she lowers her eyes and hands me the phone. On the other end of the line, a woman identifies herself as a "third-party intermediary" for my insurance company. She says she is calling to inform me that the procedure I am scheduled to have in just a few minutes has been approved ... However, my chosen provider is more expensive than other options and may result in a higher co-payment. ... I ask the obvious question: "If I stay, how much will it cost me?" Her answer is that she is not authorized to give me that information.

8 Jun 2012

NAC reduces irritability in children with autism

Autism is a developmental disorder that affects social and communication skills. Irritability is a symptom of autism that can complicate adjustment at home and other settings, and can manifest itself in aggression, tantrums, and self-injurious behavior. These disruptive behaviors are frequently observed in children with autism, which may considerably affect their ability to function at home or in school.

1 Jun 2012

CDKN1C gene mutation contributes to IMAGe syndrome

A gene previously linked to too much growth in patients has now also been linked to growth restriction. Different forms of the gene can lead to very different conditions, according to research published today in the journal Nature Genetics.

28 May 2012

Researchers identify new functions of cohesin SA1 that are relevant for cancer and CdLS

Cohesin is a ring-shaped protein complex involved in the spatial organization of the genome and in mitotic chromosome structure. Vertebrate somatic cells have two versions of cohesin that contain either SA1 or SA2, but their functional specificity has been largely ignored. Researchers of the Spanish National Cancer Research Centre (CNIO) under the direction of Ana Losada have identified new functions of cohesin SA1 that are relevant for two human diseases, cancer and Cornelia de Lange Syndrome.

4 May 2012

UCSF scientists assemble high-value genetic resource to help researchers

One of the ultimate ways of understanding what impact any particular gene has in human health or disease is to disrupt it-knocking it down or wiping it out in a worm, fly or mouse and gauging what happens next. Now scientists at the University of California, San Francisco (UCSF) Diabetes Center and the Gladstone Institute for Cardiovascular Disease have assembled a large publicly available resource to help researchers determine the importance of genes in mice and better gauge what roles they might play in disease.

17 Apr 2012

The urgency of autism: Progress in combating it, even as diagnoses increase

News outlets examine progress being made in diagnosing autism and understanding its possible causes.

12 Apr 2012

First study to examine links between neurodevelopmental disorders and maternal metabolic conditions

A major study of the relationships between maternal metabolic conditions and the risk that a child will be born with a neurodevelopmental disorder has found strong links between maternal diabetes and obesity and the likelihood of having a child with autism or another developmental disability.

9 Apr 2012

Combination of ADHD drug and parental intervention can help children with autism

Researchers at The Ohio State University are conducting a study to determine which is more effective for helping children on the autism spectrum: training parents or taking medication.

4 Apr 2012

Autism cases rise by 23% from ’06 to ’08: CDC report

According to latest figures, nearly one in 88 U.S. children have autism spectrum disorders. The report further urges national attention on the need for earlier diagnosis and treatment, especially in rural and minority communities.

1 Apr 2012

Exposure to radiation from cell phones during pregnancy affects brain development of offspring

Exposure to radiation from cell phones during pregnancy affects the brain development of offspring, potentially leading to hyperactivity, Yale School of Medicine researchers have determined.

16 Mar 2012

Viewpoints: America's mixed views on health; Contraception and political 'excesses'; Colorado Medicaid debate

Most people tell pollsters they like the parts of the law that have gone into effect: health insurance for people with preexisting conditions, a clause that allows children to stay on their parents' health plans until the age of 26 and discounts for prescription drugs on Medicare. And, as time goes by, Americans seem less worried that the law will have a negative effect on their own medical care ... But the law itself isn't any more popular than the day it passed.

12 Mar 2012

Study focuses on genetic markers in the diagnosis of autism

Cleveland Clinic Children's Hospital has launched a study to determine whether genetic markers can be used to help identify children who are at risk of developing autism.

1 Mar 2012

Scientists identify and describe molecular mechanism behind holoprosencephaly

Researchers of the Max Delbr-ck Center for Molecular Medicine (MDC) Berlin-Buch have now identified and described a molecular mechanism underlying the most common malformation of the brain in humans. In holoprosencephaly (HPE), the forebrain (prosencephalon) is only incompletely formed.

14 Feb 2012

OHSU research sheds light on molecules involved in cardiorespiratory control

Researchers at Oregon Health & Science University have discovered that a molecule critical to the development and plasticity of nerve cells - brain-derived neurotrophic factor -- is severely lacking in brainstem neurons in mutations leading to Rett syndrome, a neurological developmental disorder.

30 Jan 2012

Birth weight plays a role in autism spectrum disorder

Although the genetic basis of autism is now well established, a growing body of research also suggests that environmental factors may play a role in this serious developmental disorder affecting nearly one in 100 children. Using a unique study design, a new study suggests that low birth weight is an important environmental factor contributing to the risk of autism spectrum disorder.

20 Jan 2012