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Structural insights into glycine transporter open new avenues to find effective psychiatric drugs

Glycine can stimulate or inhibit neurons in the brain, thereby controlling complex functions. Unraveling the three-dimensional structure of the glycine transporter, researchers have now come a big step closer to understanding the regulation of glycine in the brain.

4 Mar 2021

Researchers identify drug target to fight Parkinson’s and Alzheimer’s disease

Neurodegenerative disorders such as Parkinson's and Alzheimer's disease are in the firing line after researchers identified an attractive therapeutic drug target.

3 Mar 2021

Off-Axis Parabolic Mirrors Assist Accurate 3D Flight Tracking

Optical Surfaces Ltd has been selected by the Optical Engineering Group at the University of Warwick (UK) School of Engineering to supply key focusing optics to enable accurate 3D tracking and analysis of mosquito flight behaviour.

3 Mar 2021

New insights on structural biology may help design more efficient antibodies

In structural biology, some molecules are so unusual they can only be captured with a unique set of tools.

18 Feb 2021

Researchers receive $1,894,271 grant to address new drug targets for diastolic dysfunction

After the left ventricle of the heart contracts, it must relax efficiently to prepare to refill and supply the body with blood on the next beat. An increasing number of patients -- including nearly all patients with heart failure -- suffer from impaired relaxation, which is part of a clinical syndrome known as diastolic dysfunction. Currently, treatments for impaired relaxation do not exist.

12 Feb 2021

Researchers use new imaging technique to understand motor deficits in ALS disease

An interdisciplinary team of the Institut national de la recherche scientifique (INRS) used an innovative imaging technique for a better understanding of motor deficits in Amyotrophic Lateral Sclerosis (ALS).

29 Jan 2021

Avalanching nanoparticles may advance real-time bioimaging of cell's organelles and proteins

Since the earliest microscopes, scientists have been on a quest to build instruments with finer and finer resolution to image a cell's proteins - the tiny machines that keep cells, and us, running.

14 Jan 2021

Researchers discover antibody that blocks the spread of dengue virus

A team of researchers led by the University of California, Berkeley and the University of Michigan has discovered an antibody that blocks the spread within the body of the dengue virus, a mosquito-borne pathogen that infects between 50 and 100 million people a year.

14 Jan 2021

Researchers develop novel antibody fragments against SARS coronavirus-2

An international research team led by the University of Bonn (Germany) has identified and further developed novel antibody fragments against the SARS coronavirus-2. These "nanobodies" are much smaller than the classic antibodies used to treat US President Donald Trump, for example.

13 Jan 2021

Biologists reveal unusual structure of coronavirus protein linked to immune evasion

A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells.

13 Jan 2021

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

12 Jan 2021

Scientists aim to understand bone-conducted speech transmission process

The perception of our own voice depends on sound transmission through air (air-conducted) as well as through the skull bone (bone-conducted or BC). The transmission properties of BC speech are, however, not well understood.

7 Jan 2021

Tomocube’s HT-2 microscope quantifies therapeutic effects of targeted nanodrugs against atherosclerosis

Treatment of Atherosclerosis, the disease responsible for approximately half of all deaths in westernized societies, is a step closer following correlative studies using Tomocube’s HT-2 microscope.

From Tomocube Inc. 16 Nov 2020

APS technique shows how SARS-CoV-2 virus camouflages itself inside the human body

Scientists using the Advanced Photon Source have discovered new insights into the ways the SARS-CoV-2 virus camouflages itself inside the human body.

30 Oct 2020

Bruker introduces Vutara™ VXL best-in-class super-resolution microscope and spatial biology analysis capabilities

Bruker Corporation today announced the release of the Vutara VXL Super-Resolution Fluorescence Microscope for nanoscale biological imaging. The new system opens an affordable and easy-to-use path for both core facilities and individual investigators to enter the world of super-resolution imaging by incorporating Bruker’s industry-leading single-molecule localization (SML) technology in a streamlined system with compact footprint.

From Bruker Nano Surfaces and Metrology 23 Oct 2020

Researchers successfully perform terahertz imaging of early-stage breast cancer without staining

A team of researchers at Osaka University, in collaboration with the University of Bordeaux and the Bergonié Institute in France, has succeeded in terahertz imaging of early-stage breast cancer less than 0.5 mm without staining, which is difficult to identify even by pathological diagnosis.

21 Oct 2020

Scientists refine SARS-CoV-2 protein structures

An international team of scientists has developed computational models to re-analyze and validate experimentally-derived publicly available macromolecular structures of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

8 Oct 2020

New approach to reveal high-resolution protein structural details

The number of proteins in the human body, collectively known as the proteome, is vast. Somewhere between 80,000 and 400,000 proteins circulate in our cells, tissues and organs, carrying out a broad range of duties essential for life.

6 Oct 2020

New technique enables real-time observation of influenza A hemagglutinin during viral entry

Unlike living organisms, to avoid extinction, viruses need to hijack living host machineries to generate new viruses.

17 Aug 2020

High-speed atomic force microscopy reveals diverse amyloid structures and dynamics

In the human body, proteins sometimes occur in fibrillar aggregates called amyloids. Although certain amyloids are known to have a biological function, amyloid formation is often associated with pathologies, including Alzheimer's and Parkinson's diseases.

3 Aug 2020