Dopamine News and Research RSS Feed - Dopamine News and Research

Dopamine is a hormone and neurotransmitter occurring in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this phenethylamine functions as a neurotransmitter, activating the five types of dopamine receptors — D1, D2, D3, D4 and D5, and their variants. Dopamine is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area. Dopamine is also a neurohormone released by the hypothalamus. Its main function as a hormone is to inhibit the release of prolactin from the anterior lobe of the pituitary. Dopamine has many functions in the brain, including important roles in behavior and cognition, motor activity, motivation and reward, inhibition of prolactin production (involved in lactation), sleep, mood, attention, and learning. Dopaminergic neurons (i.e., neurons whose primary neurotransmitter is dopamine) are present chiefly in the ventral tegmental area (VTA) of the midbrain, substantia nigra pars compacta, and arcuate nucleus of the hypothalamus.
TSRI scientists find evidence supporting new therapeutic strategy against cocaine addiction

TSRI scientists find evidence supporting new therapeutic strategy against cocaine addiction

An international team led by scientists at The Scripps Research Institute has found strong evidence supporting a new strategy against drug addiction. [More]
Drugs designed to target nervous system could control inflammation in the gut, study shows

Drugs designed to target nervous system could control inflammation in the gut, study shows

There's a reason it's called a gut feeling. The brain and the gut are connected by intricate neural networks that signal hunger and satiety, love and fear, even safety and danger. These networks employ myriad chemical signals that include dopamine, a powerful neurotransmitter most famous for its role in reward and addiction. [More]
New laboratory model replicates early phase of Parkinson's before onset of motor symptoms

New laboratory model replicates early phase of Parkinson's before onset of motor symptoms

They're two of the biggest mysteries in Parkinson's disease research--where does the disease start? And how can it be stopped early in the process? Now, a new laboratory model of Parkinson's is giving scientists an inside look at what happens in the brain years before motor symptoms appear. [More]
Activation of specific neural circuit can inhibit binge-like eating behavior in mice

Activation of specific neural circuit can inhibit binge-like eating behavior in mice

While binge eating affects about 10 percent of adults in the United States, the neurobiological basis of the disease is unclear. [More]
Scientists make major advance in understanding how stem cells become specialized

Scientists make major advance in understanding how stem cells become specialized

Scientists at Sanford Burnham Prebys Medical Discovery Institute have made a major advance in understanding how the cells of an organism, which all contain the same genetic information, come to be so diverse. [More]
Scientists develop interactive model to fast-track research and treatment of schizophrenia

Scientists develop interactive model to fast-track research and treatment of schizophrenia

It's called mental imbalance for a reason. Sanity hangs, in part, in the gentle balance of chemicals strung together within regions of the brain in an intricate matrix. [More]
UTA researchers find how changing estrogen levels make women more vulnerable to cocaine addiction

UTA researchers find how changing estrogen levels make women more vulnerable to cocaine addiction

Researchers at The University of Texas at Arlington are studying how fluctuating estrogen levels make females increasingly sensitive to the rewarding effects of cocaine and ultimately, vulnerable to cocaine addiction. [More]
Scientists use animal model to gain better understanding of cocaine addiction

Scientists use animal model to gain better understanding of cocaine addiction

Scientists at Wake Forest Baptist Medical Center are one step closer to understanding what causes cocaine to be so addictive. The research findings are published in the current issue of the Journal of Neuroscience. [More]
Overcoming gene silencing barriers to target neurological conditions: an interview with Dr Errol de Souza

Overcoming gene silencing barriers to target neurological conditions: an interview with Dr Errol de Souza

Many gene mutations that cause neurological disorders have been identified. For example, in a rare neurological disorder such as Huntington’s disease, an autosomal dominant mutation through expansion of CAG (cytosine-adenine-guanine) triplet repeats in the gene coding for the Huntingtin protein results in abnormal protein production. [More]
Scientists make a big leap on mini-brain research

Scientists make a big leap on mini-brain research

Scientists in Singapore have made a big leap on research on the 'mini-brain'. These advanced mini versions of the human midbrain will help researchers develop treatments and conduct other studies into Parkinson's Disease and ageing-related brain diseases. [More]
Changes in the brain's pleasure center may decrease physical activity in postmenopausal women

Changes in the brain's pleasure center may decrease physical activity in postmenopausal women

As women enter menopause, their levels of physical activity decrease; for years scientists were unable to determine why. [More]
Smoking-related deficits in brain dopamine return to normal after quitting, study reports

Smoking-related deficits in brain dopamine return to normal after quitting, study reports

A new study in Biological Psychiatry reports that smoking-related deficits in brain dopamine, a chemical implicated in reward and addiction, return to normal three months after quitting. [More]
New research elucidates details about architecture of synaptic transmission

New research elucidates details about architecture of synaptic transmission

For more than a century, neuroscientists have known that nerve cells talk to one another across the small gaps between them, a process known as synaptic transmission. [More]
Study finds risk markers for Parkinson's disease hiding in unusual spots

Study finds risk markers for Parkinson's disease hiding in unusual spots

Clues that point toward new risk mechanisms for developing Parkinson's disease are hiding in some unusual spots, according to a study published today in Scientific Reports [More]
Study sheds light on neuronal circuits during risky behavior

Study sheds light on neuronal circuits during risky behavior

New research sheds light on what's going on inside our heads as we decide whether to take a risk or play it safe. Scientists at Washington University School of Medicine in St. Louis located a region of the brain involved in decisions made under conditions of uncertainty, and identified some of the cells involved in the decision-making process. [More]
Scientists receive $2.4 million grant to advance stem cell therapy for Parkinson's disease

Scientists receive $2.4 million grant to advance stem cell therapy for Parkinson's disease

Scientists at The Scripps Research Institute and Scripps Clinic have received a grant of nearly $2.4 million from the California Institute for Regenerative Medicine to support safety and quality tests of a potential stem cell therapy for Parkinson's disease. [More]
Study examines link between craving and glutamate levels in the brain of patients with AUDs

Study examines link between craving and glutamate levels in the brain of patients with AUDs

Craving consists of cognitive, emotional, and behavioral elements related to a desire to drink alcohol, and can be experienced during intoxication, withdrawal, and/or prior to relapse. [More]
Researchers discover novel neuroprotection strategies to slow progression of Parkinson's disease

Researchers discover novel neuroprotection strategies to slow progression of Parkinson's disease

Using a robust model for Parkinson's disease, University of Alabama at Birmingham researchers and colleagues have discovered an interaction in neurons that contributes to Parkinson's disease, and they have shown that drugs now under development may block the process. [More]
Study compares aripiprazole and quetiapine for treatment of schizophrenia

Study compares aripiprazole and quetiapine for treatment of schizophrenia

Schizophrenia is a common cause of incapacity and is ranked as the third-most-disabling illness subsequent to dementia and quadriplegia. [More]
Scientists reveal how manipulating novel target in the brain could lead to new therapies for depression

Scientists reveal how manipulating novel target in the brain could lead to new therapies for depression

Northwestern Medicine scientists have shown how manipulating a novel target in the brain using gene therapy could lead to new treatments for depression. [More]
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