Drug Metabolism News and Research

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Why Primary Cells Are Important for In Vitro ADME-Tox Studies

Lonza is a large, multinational corporation serving the entire pharmaceutical product development and manufacturing pipeline, from non-clinical research products to final dosage and delivery solutions.

From Lonza 26 Mar 2020

Popular painkiller may have more significant effects on the liver than expected

The popular painkiller ibuprofen may have more significant effects on the liver than previously thought, according to new research from the University of California, Davis.

11 Mar 2020

People with drug-induced liver damage could continue taking life-saving medications

When you ingest a drug--whether over-the-counter Tylenol or medication prescribed by a doctor--your liver is your body's first responder.

28 Feb 2020

Research provides insights about sex- and gender-specific aspects of medicine

At present, a focus on males in basic research and clinical trials means that models of disease are also based on men. Symptoms and disease progression in male patients are therefore considered the standard, while disease manifestations that are usually observed in women are judged "atypical".

28 Jan 2020

Human organ chips for better drug development

The process of developing new drugs is both difficult and costly. It is estimated that of all the drug candidates which start out on their testing journey, less than 14% actually make it to the clinical scene and receive approval by the US Food and Drug Administration (FDA).

27 Jan 2020

Kobe scientists develop mathematical model to predict cancer drug side effects

A research team at Kobe University Hospital have further illuminated the likelihood of cancer drug side effects that can occur due to genetic mutations in the drug-metabolizing enzyme.

20 Dec 2019

Discovery could offer insight into different risk of diseases in African Americans

The percentage of African ancestry in a person's genome determines the level that certain genes are expressed, called mRNA, according to a new Northwestern Medicine study.

3 Dec 2019

Validation of new method for studying how different drugs interact in the body

Scientists at Oregon State University may have proven how much people love coffee, tea, chocolate, soda and energy drinks as they validated their new method for studying how different drugs interact in the body.

26 Nov 2019

Key mechanism identified for how antiviral immune responses reprogram liver metabolism

Researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences identified a key mechanism for how antiviral immune responses reprogram liver metabolism. Their recent study, which was published in the renowned scientific journal Immunity, investigated the communication between inflammation and liver metabolism during chronic viral infection.

26 Nov 2019

Single vaping episode of cannabis could yield positive results in urine drug tests

In a study of six adults, Johns Hopkins Medicine researchers report evidence that a single vaping episode of cannabis that is similar in chemical composition to that found in legal hemp products could possibly result in positive results on urine drug screening tests commonly used by many employers and criminal justice or school systems.

From Johns Hopkins Medicine 4 Nov 2019

Group of genes linked to longer lifespan in fruit flies discovered

Alexey Moskalev, Ph.D., Head of the Laboratory of Geroprotective and Radioprotective technologies, and co-authors from the Institute of biology of Komi Science Center of RAS, the Engelgard's Institute of molecular biology of RAS and Moscow Institute of Physics and Technology published a scientific article titled "Transcriptome Analysis of Long-lived Drosophila melanogaster E(z) Mutants Sheds Light on the Molecular Mechanisms of Longevity" in Nature Scientific Reports - the leading international multidisciplinary weekly journal.

19 Jul 2019

Vitamin D metabolite may stop mechanism by which cancer cells become drug-resistant

What's good for our bones may also help stop cancer cells that develop resistance to multiple chemotherapy drugs.

14 Jun 2019

CN Bio to bring 10 organs together on a chip

London Organ-on-Chip specialist CN Bio today announced it has secured an exclusive license to technology from the Massachusetts Institute of Technology for Organ-on-Chip systems which connect human tissues from up to 10 organs.

From CN-Bio 28 Feb 2019

Pharmacogenetic tests don't provide much information for prescribing antidepressants or antipsychotics

Pharmacogenetic tests are marketed as an aid to psychiatrists in selecting the antidepressant or antipsychotic medication that will work best in individual patients, based on their genetic makeup.

21 Nov 2018

Study finds changes in antiepileptic drug metabolism during different trimesters of pregnancy

During pregnancy, the numerous physiological changes a woman's body undergoes can alter the way medications are metabolized, the rate at which they are cleared, and their overall effectiveness.

17 Oct 2018

Study highlights need for population-specific precision medicine programs in Latin America

Drug safety and effectiveness vary greatly among populations worldwide. Genetics is one of the factors that contribute to variability in drug response.

3 Oct 2018

Breakthrough fluorine discovery may impact how pharmaceutical companies develop new drugs

A groundbreaking discovery by chemists at The University of Texas at San Antonio will have a significant impact on how pharmaceutical companies develop new drug treatments.

6 Sep 2018

New research explores why minority children have worse cancer outcomes

New research will focus on finding better treatments for minority children with high-risk cancer malignancies - a group whose outcomes and survival rates are worse than other pediatric patients.

11 Jun 2018

Experts explore how degenerative processes impair the body's detoxification system

A poor diet and other risk factors can result in liver disease. This important metabolic organ can become fatty and inflamed. In the long term, this may result in irreversible and life-threatening organ damage (cirrhosis of the liver or 'shrunken liver').

9 Apr 2018

Leukemia itself may increase risk for long-term neurocognitive problems in survivors

Leukemia itself, not just side effects related to its treatment, may increase the risk for long-term problems with attention, organization and related neurocognitive skills in survivors of the most common childhood cancer, according to research from St. Jude Children's Research Hospital. The study appears today in the journal JAMA Oncology.

29 Mar 2018