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Ongoing treatment with nivolumab shows benefit in advanced kidney cancer patients

Ongoing treatment with nivolumab shows benefit in advanced kidney cancer patients

Only 12% of kidney cancer patients with advanced disease survive five years after their initial treatment. In a Roswell Park Cancer Institute-led study, scientists report that some patients with advanced kidney cancer who continued to receive a novel immunotherapy drug after their disease progressed saw clinical benefit. [More]
Aliskiren fails to show benefit for heart failure patients with diabetes

Aliskiren fails to show benefit for heart failure patients with diabetes

A subgroup analysis in heart failure patients with diabetes from the ATMOSPHERE trial has failed to show benefit and signals the end of the road for aliskiren in heart failure. [More]
Chemical compound eCF506 may be highly effective at blocking growth of breast cancer cells

Chemical compound eCF506 may be highly effective at blocking growth of breast cancer cells

A drug for breast cancer that is more effective than existing medicines may be a step closer thanks to new research. [More]
Scientists find ketamine as effective sedative for treating highly-agitated patients prior to hospitalisation

Scientists find ketamine as effective sedative for treating highly-agitated patients prior to hospitalisation

Scientists have shown that ketamine is far more effective than the more commonly used haloperidol for treating highly-agitated patients prior to hospitalisation. [More]
Small lipid nanocarrier may deliver chemotherapeutic drug more efficiently to brain tumor cells

Small lipid nanocarrier may deliver chemotherapeutic drug more efficiently to brain tumor cells

Great discoveries do come in small packages. Few know that better than Ann-Marie Broome, Ph.D., who feels nanotechnology holds the future of medicine with its ability to deliver powerful drugs in tiny, designer packages. [More]
High-resolution image of Zika virus helicase may help develop antiviral drugs

High-resolution image of Zika virus helicase may help develop antiviral drugs

A team led by researchers from Tianjin University has solved the structure of the Zika virus helicase, which is a key target for antiviral development. The research is published in Springer's journal Protein & Cell. [More]
Researchers identify potential ways in which cancer cells may develop resistance to BET inhibitors

Researchers identify potential ways in which cancer cells may develop resistance to BET inhibitors

A team of Walter and Eliza Hall Institute researchers has worked out how a new class of anti-cancer drugs kills cancer cells, a finding that helps explain how cancer cells may become resistant to treatment. [More]
Combination of chemotherapy and immunotherapy may be effective against ovarian cancer

Combination of chemotherapy and immunotherapy may be effective against ovarian cancer

Inside each ovarian tumor, there are good cells and bad cells: The bad cells are fibroblasts. They work to block chemotherapy, which is why nearly every woman with ovarian cancer becomes resistant to treatment. [More]
Harvard researchers create new, simplified platform for antibiotic discovery

Harvard researchers create new, simplified platform for antibiotic discovery

Harvard researchers have created a new, greatly simplified, platform for antibiotic discovery that may go a long way to solving the crisis of antibiotic resistance. [More]
DECT trial shows combination of epirubicin and trastuzumab improves outcomes in breast cancer patients

DECT trial shows combination of epirubicin and trastuzumab improves outcomes in breast cancer patients

The study entitled "A phase II neoadjuvant sequential regimen of docetaxel followed by high-dose epirubicin in combination with cyclophosphamide administered concurrently with trastuzumab. [More]
Cochrane review explores FDCs versus single-drug formulations for treatment of pulmonary TB

Cochrane review explores FDCs versus single-drug formulations for treatment of pulmonary TB

A research team from Spain has prepared a Cochrane systematic review that explores the efficacy, safety, and adherence to fixed-dose combinations (FDCs) of drugs versus single-drug formulations to treat people who are newly diagnosed with tuberculosis (TB). [More]
Pre-procedural use of antiplatelet therapy becoming less routine in heart attack treatment

Pre-procedural use of antiplatelet therapy becoming less routine in heart attack treatment

Doctors worried about dangerous blood clots in patients undergoing a coronary artery procedure— such as angioplasty to treat a heart attack — will often administer antiplatelet therapy to head off complications. [More]
Phase I study of triple drug combination shows promise in multiple myeloma patients

Phase I study of triple drug combination shows promise in multiple myeloma patients

PharmaMar announces the positive results from a Phase I study of plitidepsin in combination with bortezomib and dexamethasone in patients with relapsed and/or refractory multiple myeloma. [More]
Wresting back control of CHI3L1 protein could stave off cancer spread in mice

Wresting back control of CHI3L1 protein could stave off cancer spread in mice

For cancer to spread, the cells that take off into the bloodstream must find a tissue that will permit them to thrive. They don't just go looking, though. Instead, they actively prepare the tissue, in one case by co-opting a protein that suppresses defenses the body would otherwise mount. [More]
Regular use of laxatives may flatten rigidity found in Parkinson's disease

Regular use of laxatives may flatten rigidity found in Parkinson's disease

In a recent retrospective analysis, investigators discovered that the year-on-year increase in rigidity found in Parkinson's disease flattened off with the regular use of laxatives to manage constipation. [More]
New experimental model may predict eventual cardiac phenotype in pediatric patients

New experimental model may predict eventual cardiac phenotype in pediatric patients

An experimental model uses genetics-guided biomechanics and patient-derived stem cells to predict what type of inherited heart defect a child will develop, according to authors of a new study in the journal Cell. [More]
Specific monocyte immune cells serve as link between gut bacteria and the brain

Specific monocyte immune cells serve as link between gut bacteria and the brain

A special kind of immune cell serves as an intermediary between gut bacteria and the brain. Dr. Susanne Wolf of the Max Delbruck Center for Molecular Medicine in the Helmholtz Association discovered this in tests on mice and published her findings in the journal Cell Reports. [More]
Researchers urge specific guidelines for fertility, sexual function counseling in at-risk pediatric patients

Researchers urge specific guidelines for fertility, sexual function counseling in at-risk pediatric patients

The drugs and therapies used to treat medical conditions often come with side effects. Doctors, pharmacists and other health care professionals strive to be sure we are made aware. [More]
Breakthrough technique removes potentially harmful additives from common injectable drugs

Breakthrough technique removes potentially harmful additives from common injectable drugs

Bring the drugs, hold the suds. That summarizes a promising new drug-making technique designed to reduce serious allergic reactions and other side effects from anti-cancer medicine, testosterone and other drugs that are administered with a needle. [More]
AstraZeneca, MedImmune to provide update on extensive oncology pipeline at ASCO 2016

AstraZeneca, MedImmune to provide update on extensive oncology pipeline at ASCO 2016

AstraZeneca and its global biologics research and development arm, MedImmune, will provide an update on their extensive oncology pipeline at the annual meeting of the American Society of Clinical Oncology in Chicago, USA, on 3-7 June 2016. [More]
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