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TAU research highlights neuroprotective potential of protein-protectant drug candidate SKIP

TAU research highlights neuroprotective potential of protein-protectant drug candidate SKIP

Activity-dependent neuroprotective protein (ADNP), essential for brain formation, is frequently mutated in children on the autism spectrum. In older men and women, ADNP expression in the blood is correlated with cognition and further altered in Alzheimer's disease. [More]
Novel test could help get best treatment for advanced bowel cancer patients

Novel test could help get best treatment for advanced bowel cancer patients

A NEW test could help patients with advanced bowel cancer get the best treatment for their disease, according to a Cancer Research UK clinical trial published today (Thursday) in JAMA Oncology. [More]
Apps that test visual function at home can identify vision problems long before traditional tests

Apps that test visual function at home can identify vision problems long before traditional tests

Apps that test visual function at home can discover deterioration of the eye's macula lutea long before traditional vision tests. A doctoral thesis at Sahlgrenska Academy explored this issue. [More]
Leeds scientists to start computer drug research to find cure for Ebola virus

Leeds scientists to start computer drug research to find cure for Ebola virus

Scientists at the University of Leeds will run the equivalent of password cracking software to find the chemical keys to defeating the Ebola virus. [More]
Unlocking intrinsically disordered proteins: an interview with Peter Wright

Unlocking intrinsically disordered proteins: an interview with Peter Wright

I'm a professor in the Department of Integrative Structural and Computational Biology at The Scripps Research Institute. I have been performing NMR research on proteins for nearly 40 years. [More]
CMU researchers create robotically-driven experimentation system to reduce drug discovery cost

CMU researchers create robotically-driven experimentation system to reduce drug discovery cost

Researchers from Carnegie Mellon University have created the first robotically driven experimentation system to determine the effects of a large number of drugs on many proteins, reducing the number of necessary experiments by 70 percent. [More]
Yale Cancer Center researchers identify cause of myeloma

Yale Cancer Center researchers identify cause of myeloma

Yale Cancer Center researchers have identified what causes a third of all myelomas, a type of cancer affecting plasma cells. The findings, published in the Feb. 11 issue of the New England Journal of Medicine, could fundamentally change the way this cancer and others are treated. [More]
Simple physics may play key role in helping the body to fight infection

Simple physics may play key role in helping the body to fight infection

Simple physics may play a larger role than previously thought in helping control key bodily processes - such as how the body fights infection. [More]
Penn investigators explore new treatment option for cocaine dependence

Penn investigators explore new treatment option for cocaine dependence

In the ongoing fight against drug addiction, researchers from the University of Pennsylvania's School of Nursing and Perelman School of Medicine have discovered a unique application for an FDA-approved drug currently used for obese patients and type 2 diabetics: treatment for cocaine dependence. [More]
Study provides new insight into how drug addicts' brains wired differently

Study provides new insight into how drug addicts' brains wired differently

A study out today provides new insight into how the brains of drug addicts may be wired differently. The findings, which appear in the journal Psychopharmacology, show that while drug users have very strong motivation to seek out "rewards," they exhibit an impaired ability to adjust their behavior and are less fulfilled once they have achieved what they desire. [More]
Researchers devise lipid-based diets to relieve symptoms of Alzheimer's disease

Researchers devise lipid-based diets to relieve symptoms of Alzheimer's disease

Alzheimer´s disease (AD) is the most common disease underlying memory problems and dementia in the elderly. One of the invariable pathologies in AD is degeneration of cholinergic synapses in brain cortex and hippocampus. [More]
Boosting intrinsic growth programs can enhance axon regeneration of injured neurons

Boosting intrinsic growth programs can enhance axon regeneration of injured neurons

Damage to axons in the central nervous system (CNS) typically results in permanent functional deficits. Boosting intrinsic growth programs can dramatically augment the axon regeneration of injured neurons. If injured neurons can regenerate sufficient number of axons, the CNS may recover and overcome such functional deficits. [More]
UPMC uses simple gene test to personalize medications for patients undergoing heart catheterization

UPMC uses simple gene test to personalize medications for patients undergoing heart catheterization

Patients who go to UPMC Presbyterian for heart catheterization and who receive a stent to treat clogged arteries are now being screened with a simple blood test to determine if they have a gene variant that makes them less likely to respond to a blood-thinning medication commonly prescribed after the procedure. [More]
Scientists propose use of mathematical models to find better treatment for bladder cancer

Scientists propose use of mathematical models to find better treatment for bladder cancer

MIPT scientists together with their colleagues from St. Petersburg and Israel have analyzed more than 500 previously published scientific articles and proposed their own approach to the choice of methods used for the treatment of one of the most common cancers. [More]
SBP researchers identify molecular switch that controls genes needed to repair skeletal muscle

SBP researchers identify molecular switch that controls genes needed to repair skeletal muscle

Researchers at Sanford Burnham Prebys Medical Research Institute (SBP) have conclusively identified the protein complex that controls the genes needed to repair skeletal muscle. [More]
Kumamoto University researchers identify protein that limits severity of Alport syndrome

Kumamoto University researchers identify protein that limits severity of Alport syndrome

Researchers from Kumamoto University, Japan have identified a protein that limits the severity of Alport syndrome, a type of genetic kidney disease. The finding can provide clues that point toward new therapeutic approaches for Alport syndrome. [More]
TSRI scientists develop new screening device for drug discovery

TSRI scientists develop new screening device for drug discovery

Screening large "libraries" of compounds to find those with a desired biological activity is a powerful method for discovering new drugs, but requires a large, expensive and dedicated facility. Now, scientists at the Florida campus of The Scripps Research Institute have devised the central component of a screening system that would be orders of magnitude smaller and cheaper. [More]
Drugs designed to curb Rac1 signaling pathway may help relieve inflammatory pain in sufferers

Drugs designed to curb Rac1 signaling pathway may help relieve inflammatory pain in sufferers

New research uncovers a cascade of reactions within nerve cells that relay sensations of pain associated with inflammation. The findings, which are published in the British Journal of Pharmacology, indicate that drugs designed to curb this pathway may help relieve inflammatory pain in sufferers. [More]
Five researchers named winners of 2016 Elsevier Foundation Awards

Five researchers named winners of 2016 Elsevier Foundation Awards

Five researchers have been named winners of the 2016 Elsevier Foundation Awards for Early Career Women Scientists in the Developing World, in recognition of research that has strong potential health and economic benefits. [More]
2D-NMR could be a powerful complementary technique for assessing biosimilarity of protein drugs

2D-NMR could be a powerful complementary technique for assessing biosimilarity of protein drugs

A first-ever interlaboratory study of four versions of a therapeutic protein drug—all manufactured from living cells—reports that an established analytical tool akin to magnetic resonance imaging reliably assessed the atomic structures of the biologically similar products, yielding the equivalent of a fingerprint for each. [More]
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