Duloxetine News and Research

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Duloxetine is approved in the United States for the acute and maintenance treatment of major depressive disorder, the acute treatment of generalized anxiety disorder, and the management of diabetic peripheral neuropathic pain and fibromyalgia in adults aged 18 years and older. Duloxetine is not approved for use in pediatric patients.

New drug shows promise for treating chronic neuropathic pain

A non-opioid designer molecule for treating chronic neuropathic pain by calming hyperactive pain-sensing neurons in the peripheral nervous system has had promising results in a preclinical study conducted by researchers at Weill Cornell Medicine and the Burke Neurological Institute.

2 Aug 2023

Some antidepressants may be effective in treating chronic pain, but others lack effectiveness

New research has found some antidepressants may be effective in treating certain chronic pain conditions, but others lack convincing evidence on their effectiveness.

1 Feb 2023

Commonly prescribed antidepressants can increase bacteria's resistance to antibiotics

University of Queensland researchers have found a range of commonly prescribed antidepressants can increase bacteria's resistance to antibiotic medications.

1 Feb 2023

Researchers assess the evidence basis for medications used to treat spine-related pain in older adults

Spine-related pain is increasingly common in older adults. While medications play an important role in pain management, their use has limitations in geriatric patients due to reduced liver and kidney function, comorbid medical problems and polypharmacy (the simultaneous use of multiple drugs to treat medical conditions).

28 Jun 2022

Study examines if antidepressants can benefit patients with osteoarthritis

A clinical trial published in Arthritis & Rheumatology recently examined whether duloxetine, a medication that is prescribed to treat depression and may also reduce chronic pain, can benefit patients with hip or knee osteoarthritis.

6 Jan 2022

AAN issues new guideline on oral and topical treatments for painful diabetic neuropathy

Diabetic neuropathy refers to nerve damage due to diabetes and it may lead to pain and numbness, most often in the hands and feet. To help neurologists and other doctors determine the best treatment for people with diabetic neuropathy, the American Academy of Neurology (AAN) has issued a guideline on oral and topical treatments for painful diabetic neuropathy.

28 Dec 2021

Drug accumulation alters gut bacterial metabolism and composition

In a research paper recently published in the journal Nature by Klünemann et al. (September 8th, 2021), the interaction of 15 diverse drugs with 25 common strains of gut bacteria is investigated, revealing 70 bacteria-drug interactions that include 29 entirely novel mechanisms not yet reported.

15 Sep 2021

Study finds accumulation of common therapeutic drugs by gut bacteria

Common medications can accumulate in gut bacteria, a new study has found, altering bacterial function and potentially reducing the effectiveness of the drug.

8 Sep 2021

Study: Duloxetine may reduce cumulative opioid use after total knee arthroplasty

In a study conducted by researchers at Hospital for Special Surgery (HSS), cumulative opioid use was reduced by 30% in a patient group that received duloxetine after total knee arthroplasty (TKA) compared with patients who received placebo.

13 May 2021

Antidepressants provide no important benefits for managing low back pain

A new systematic review led by UNSW Sydney has found that treating low back pain with antidepressant medicines provides no important benefits and has the potential to cause harm.

8 Mar 2021

Study reveals potential risk factors for developing nerve damage after cancer treatment

A low hemoglobin count, older age and high BMI are possible risk factors for developing nerve damage after cancer treatment, a UNSW-led study has found.

4 Mar 2021

Enriched diet and companionship can reduce pain in mice with sickle cell disease

Researchers from the University of California, Irvine and the University of Minnesota have found that an enriched diet and companionship can reduce pain in mice with sickle cell disease by increasing serotonin.

1 Feb 2021

Researchers reveal new mechanism of pain control

Researchers in Japan have revealed a previously unknown mechanism for pain control involving a newly identified group of cells in the spinal cord, offering a potential target for enhancing the therapeutic effect of drugs for chronic pain.

25 Nov 2020

Some of the main osteoporosis treatments could have a protective effect against COVID-19

Some of the principal treatments for osteoporosis, denosumab, zoledronate and calcium, could have a protective effect against COVID-19 in patients who take them, specifically a 30 to 40% reduction in the rate of infection, according to the results of a joint study by Hospital del Mar, the Hospital del Mar Medical Research Institute (IMIM), Pompeu Fabra University and the Pere Virgili Health Park.

3 Nov 2020

Increase in out-of-pocket costs associated with lower adherence to neurologic medications

As out-of-pocket costs go up for drugs for the neurologic disorders Alzheimer's disease, peripheral neuropathy and Parkinson's disease, people are less likely to take the drugs as often as their doctors prescribed, according to a study funded by the American Academy of Neurology and published in the February 19, 2020, online issue of Neurology, the medical journal of the American Academy of Neurology.

19 Feb 2020

Duloxetine News and Research

New drug shows promise for treating chronic neuropathic pain

Some antidepressants may be effective in treating chronic pain, but others lack effectiveness

Commonly prescribed antidepressants can increase bacteria's resistance to antibiotics

Researchers assess the evidence basis for medications used to treat spine-related pain in older adults

Study examines if antidepressants can benefit patients with osteoarthritis

AAN issues new guideline on oral and topical treatments for painful diabetic neuropathy

Drug accumulation alters gut bacterial metabolism and composition

Study finds accumulation of common therapeutic drugs by gut bacteria

Study: Duloxetine may reduce cumulative opioid use after total knee arthroplasty

Antidepressants provide no important benefits for managing low back pain

Study reveals potential risk factors for developing nerve damage after cancer treatment

Enriched diet and companionship can reduce pain in mice with sickle cell disease

Researchers reveal new mechanism of pain control

Some of the main osteoporosis treatments could have a protective effect against COVID-19

Increase in out-of-pocket costs associated with lower adherence to neurologic medications

Family doctors in rural America tackle crisis of addiction and pain

Updated guideline for management of osteoarthritis of the hand, hip and knee released

Weighing risks and benefits of antidepressant medication for older adults

Finding better way to quantify neuropathy symptoms and treatment efficacy

New drug offers hope for osteoarthritis patients suffering from debilitating hand pain

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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