Dysplasia News and Research

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Dysplasia is a term used in pathology to refer to an abnormality in maturation of cells within a tissue. This generally consists of an expansion of immature cells, with a corresponding decrease in the number and location of mature cells.

Groundbreaking study unveils sex-specific genetic influences on blood pressure

Genetic heterogeneity of blood pressure (BP) effects between sexes.

12 Mar 2024

Investigational protein replacement protects neonatal mice from deadly intestinal disease

Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and colleagues found that an investigational protein replacement – recombinant human insulin-like growth factor 1 and its binding protein-3 (rhIGF-1/BP3) – protected neonatal mice from necrotizing enterocolitis (NEC), a deadly intestinal disease that often strikes extremely premature infants.

28 Feb 2024

New discovery sheds light on the genetic basis of a rare skeletal disorder

A McGill-led team of researchers have made an important discovery shedding light on the genetic basis of a rare skeletal disorder.

19 Jan 2024

UCL researchers develop new gene therapy to cure severe childhood epilepsy

UCL researchers have developed a new gene therapy to cure a devastating form of childhood epilepsy, which a new study shows can significantly reduce seizures in mice.

14 Dec 2023

Study identifies key factor in lung and eye damage in preemies

Advancements in the care of premature babies are leading to improved survival rates. However, the incidence of neonatal diseases with life-long consequences such as bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) is increasing.

11 Dec 2023

Rising colorectal cancer risk in young adults calls for earlier screening, study suggests

Study reveals an increase in adenomas and advanced adenomas in younger adults, alongside a rise in colorectal cancer incidence in males under 50, suggesting a need for earlier screening, particularly in men.

7 Dec 2023

Effects of using race and ethnicity in clinical algorithms in health care systems

A Special Issue of the peer-reviewed journal Health Equity focuses attention on the incorrect use of race and ethnicity in clinical algorithms in health care systems across the U.S. and internationally. The Special Issue is titled "Race Adjustment in Clinical Algorithms and Other Clinical Decision-making Tools."

4 Dec 2023

Pyrvinium can be repurposed as a preventative treatment for stomach cancer

A study published Oct. 4 in Gastroenterology further validates that pyrvinium, a drug that has been used for decades for intestinal pinworms, can be repurposed as a preventative treatment for stomach cancer.

6 Oct 2023

Targeting the ORAI1 calcium channel could provide new approach to treating oral cancer

An essential protein that acts as a gatekeeper for calcium entering cells promotes the growth of oral cancer and generates pain, according to a new study published in Science Signaling led by researchers at NYU College of Dentistry.

5 Sep 2023

Innovative insights into effects of hematopoietic changes on colon cancer, unveiling therapeutic avenues

Researchers investigated whether bone marrow-derived cells contribute to colitis-associated colon cancer.

29 Aug 2023

Are inflammatory bowel disease patients more at risk of colorectal cancer?

Researchers analyzed data from a large cohort of inflammatory bowel disease patients and looked at the risk and frequency of colorectal cancer.

9 Aug 2023

Researchers investigate the efficacy of a novel intra-tumoral drug delivery carrier in treating oral squamous cell carcinoma

Researchers investigated the efficacy of a novel intra-tumoral drug delivery carrier in treating oral squamous cell carcinoma.

31 Jul 2023

Universal genetic testing may improve risk stratification and treatment for rare and lethal cancer

Esophageal adenocarcinoma (EAC) is a highly lethal cancer, with a five-year survival rate of less than 20 percent. Although a precursor lesion to EAC, called Barrett's esophagus (BE), is present in roughly seven percent of middle-aged adults, less than one percent of BE patients will progress to EAC, making it difficult to determine which individuals are at risk of developing this deadly cancer.

27 Jul 2023

Researchers develop protein biomarker panels to predict developmental dysplasia of the hip

Researchers from the University of Missouri School of Medicine have developed panels of protein biomarkers present in teens and young adults that distinguish individuals with healthy hips from those with developmental dysplasia of the hip, also known as hip dysplasia, which often progresses to hip osteoarthritis if not recognized before early adulthood.

13 Jun 2023

Is the increased risk of bronchopulmonary dysplasia from high-dose docosahexaenoic acid supplementation in the neonatal period associated with changes to IQ?

Study analyzed whether a reduction in IQ benefit was associated with the increased risk of BPD with DHA supplementation.

13 Jun 2023

Innovative approach for detecting pre-cancerous lesions using large, high-res images

A new study presents an innovative approach to the crucial detection of pre-cancerous lesions using large, high-res images.

1 Jun 2023

Nemours Children's Health selected to conduct first gene therapy clinical trial for Morquio A syndrome

As part of the Foundation for the National Institutes of Health Accelerating Medicines Partnership Bespoke Gene Therapy Consortium, Nemours Children's Health has been chosen to conduct a first-of-its-kind gene therapy clinical trial for Morquio A syndrome.

16 May 2023

Primary arthroscopy provides positive long-term outcomes for young adults with borderline hip dysplasia

For young adults with borderline hip dysplasia (BHD), primary arthroscopy provides positive long-term outcomes, improving symptoms and function while avoiding the need for hip replacement surgery in most cases, reports a study in The Journal of Bone & Joint Surgery.

3 May 2023

Can smoking cigarettes alter your bone structure?

Researchers aimed to understand how exposure to cigarette smoke causes alterations in bone structure.

2 May 2023

Understanding the cervical microbiome: a promising frontier in HPV treatment

A recent feature published in PNAS provided emerging insights into microflora associated with human papillomavirus (HPV) infections.

26 Apr 2023