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Dysplasia is a term used in pathology to refer to an abnormality in maturation of cells within a tissue. This generally consists of an expansion of immature cells, with a corresponding decrease in the number and location of mature cells.

ECMO can be used on neonates with severe respiratory failure until lung transplantation, say scientists

Adults with end-stage respiratory failure and pulmonary hypertension requiring ECMO (extracorporeal membrane oxygenation) have been "bridged" toward lung transplantation with novel lung assist devices such as the Novalung. [More]
Oxygenation targets and outcomes in premature infants

Oxygenation targets and outcomes in premature infants

In a randomized trial performed to help resolve the uncertainty about the optimal oxygen saturation therapy in extremely preterm infants, researchers found that targeting saturations of 85 percent to 89 percent compared with 91 percent to 95 percent had no significant effect on the rate of death or disability at 18 months, according to a study published by JAMA. The study is being released early online to coincide with its presentation at the Pediatric Academic Societies annual meeting. [More]
SynCon universal H1N1 influenza vaccine generates protective antibody levels in phase 1 study

SynCon universal H1N1 influenza vaccine generates protective antibody levels in phase 1 study

Inovio Pharmaceuticals, Inc. announced today that its SynCon universal H1N1 influenza vaccine generated protective antibody levels comparable to a current FDA-approved seasonal influenza vaccine against a currently circulating influenza strain. [More]
KiDS of NYU Langone raises nearly $1 million at 2013 Springfling gala

KiDS of NYU Langone raises nearly $1 million at 2013 Springfling gala

NYU Langone Medical Center announced today that KiDS of NYU Langone raised nearly $1 million at its annual gala—the 2013 Springfling—held Wednesday evening at The Plaza. [More]

Study: Average-risk screening ADR is higher than current guidelines suggest for men and women

Researchers at Mayo Clinic in Jacksonville, Florida, report in a new study that average-risk screening adenoma detection rates (ADR) are significantly higher than current guidelines suggest for both men and women. [More]
Inovio Pharmaceuticals reports release of phase II clinical trial results of ChronVac-C

Inovio Pharmaceuticals reports release of phase II clinical trial results of ChronVac-C

Inovio Pharmaceuticals, Inc. today announced the release of preliminary clinical trial results by its collaborator ChronTech AS of their open label phase II clinical study of ChronVac-C, ChronTech's vaccine to treat hepatitis C virus infection. [More]
Modifiable lifestyle factors may prevent progression of Barrett's-related esophageal cancer

Modifiable lifestyle factors may prevent progression of Barrett's-related esophageal cancer

An estimated 20 million Americans have chronic heartburn. About 2 million of these people have Barrett's esophagus, a precancerous condition that affects the tube that carries food from the mouth to the stomach. [More]
New study associates commonly used diabetes drugs with pancreatic cancer risk

New study associates commonly used diabetes drugs with pancreatic cancer risk

ndividuals who had taken a type of drug commonly used to treat Type 2 diabetes showed abnormalities in the pancreas, including cell proliferation, that may be associated with an increased risk of neuroendocrine tumors, according to a new study by researchers from UCLA and the University of Florida. [More]
Research findings could lead to new treatments for lung disorders in premature babies

Research findings could lead to new treatments for lung disorders in premature babies

Researchers at Yale School of Medicine have made major discoveries that could lead to new treatments for lung disorders in premature babies. In a mouse study, the team located key molecules that switch on stress pathways in preterm lung disorders, and also found that when parts of these pathways were blocked with a pain drug, lung damage was prevented or reversed. [More]

Study finds significant variation over diuretics use in BPD patients

Even though there is little data to support the extended use of diuretic medications to help reduce fluid build-up in the lungs of premature infants, researchers at Nationwide Children's Hospital have found significant variation in how babies receive these medications at hospitals across the nation. [More]
Special issue on colorectal cancer published in GIE: Gastrointestinal Endoscopy journal

Special issue on colorectal cancer published in GIE: Gastrointestinal Endoscopy journal

In recognition of National Colorectal Cancer Awareness Month, GIE: Gastrointestinal Endoscopy has published a special issue for March on colorectal cancer. [More]
Screening healthy adults could potentially prevent rare genetic disorders

Screening healthy adults could potentially prevent rare genetic disorders

Millions of people unknowingly carry rare gene mutations that put them at high risk of developing preventable diseases such as colorectal cancer, breast cancer, and several catastrophic blood vessel disorders. [More]

Patients with Barrett's esophagus benefit from endoscope-based therapies

According to a new study by researchers at the Perelman School of Medicine at the University of Pennsylvania, patients with Barrett's esophagus and early or pre-cancerous cells have been shown to significantly benefit from minimally invasive therapy delivered through an endoscope - a medical instrument used to look inside an organ or cavity in the body. [More]
Military women more likely to contract sexually transmitted infections: Study

Military women more likely to contract sexually transmitted infections: Study

As the number of women in the military increases, so does the need for improved gynecologic care. Military women may be more likely to engage in high-risk sexual practices, be less likely to consistently use barrier contraception, and, therefore, more likely to contract sexually transmitted infections (STIs), according to research recently released by a physician at Women & Infants Hospital of Rhode Island. [More]
Researchers unveil first maturation-based ‘disease in a dish’ model for ARVD/C

Researchers unveil first maturation-based ‘disease in a dish’ model for ARVD/C

Most patients with an inherited heart condition known as arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) don't know they have a problem until they're in their early 20s. The lack of symptoms at younger ages makes it very difficult for researchers to study how ARVD/C evolves or to develop treatments. A new stem cell-based technology created by 2012 Nobel Prize winner Shinya Yamanaka, M.D., Ph.D., helps solve this problem. [More]
Skin cells transformed into heart cells for research into cardiomyopathy

Skin cells transformed into heart cells for research into cardiomyopathy

... [More]
Evidence links HPV16 to focal cortical dysplasia type IIB

Evidence links HPV16 to focal cortical dysplasia type IIB

Researchers at Shriner's Hospital Pediatric Research Center at the Temple University School of Medicine, and the University of Pennsylvania have evidence linking the human papillomavirus 16 (HPV16) - the most common cause of cervical cancer - to a common form of childhood epilepsy. [More]

Study to determine prevalence of abnormal anal cytology and HPV in at-risk women

A basic connection of statistics lead a researcher at Women & Infants Hospital of Rhode Island to question whether women should be screened for anal cancer during a regular visit to the gynecologist, and what technique is most effective. [More]

Multiple birth hip dysplasia screening questioned

Ultrasound screening for developmental dysplasia of the hip is unnecessary in twins and triplets without signs of the condition, say UK researchers. [More]
Inovio, MVI collaborate to advance malaria vaccine development and new delivery technologies

Inovio, MVI collaborate to advance malaria vaccine development and new delivery technologies

The PATH Malaria Vaccine Initiative (MVI) and Inovio Pharmaceuticals, Inc. today announced a follow-on collaboration to advance malaria vaccine development and new vaccination delivery technologies. [More]