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Study reveals structural details of omega-3 fatty acid transport across the blood–brain barrier

Spectacular images of a molecule that shuttles omega-3 fatty acids into the brain may open a doorway for delivering neurological therapeutics to the brain.

16 Jun 2021

A closer look at how COVID-19 damages human lungs

A recent study conducted at the United States Department of Energy’s (DOE) Brookhaven National Laboratory provides the first atomic-level detailed model of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope protein when bound to human proteins within the lungs. The study was recently published in Nature Communications.

9 Jun 2021

New atomic-level model helps explain how SARS-CoV-2 causes extensive lung damage

Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have published the first detailed atomic-level model of the SARS-CoV-2 "envelope" protein bound to a human protein essential for maintaining the lining of the lungs.

8 Jun 2021

Researchers find natural metabolites help SARS-CoV-2 escape antibodies

An international team of scientists has identified a human molecule — biliverdin — as a potential severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) target. The binding of the heme metabolite to the N-terminal domain of SARS-CoV-2 is associated with the virus’s ability to dodge the immune system by suppressing antibody binding to the spike protein.

2 Jun 2021

Direct action of SARS-CoV-2 on organs may lead to exacerbated inflammatory response in pediatric patients

Besides common symptoms such as fever, cough and respiratory distress, some children have an atypical form of COVID-19 known as multisystem inflammatory syndrome in children (MIS-C), characterized by persistent fever and inflammation of several organs, such as the heart and intestines, as well as the lungs to a lesser extent.

1 Jun 2021

Scientists use an original approach to resolve the 3D structure of flaviviruses

In a recent study, Australian scientists used an original approach to resolve the 3D structure of flaviviruses with an unprecedented level of detail, identifying small molecules known as 'pocket factors' as new therapeutic targets.

1 Jun 2021

Researchers discover cross-reactive coronavirus antibody triggered during COVID-19 infection

Even before the COVID-19 pandemic, most people in the United States already had been sick with a coronavirus, albeit a far less dangerous one.

28 May 2021

Potent antibody with unique genetic signature and spike recognition mechanism neutralizes SARS-CoV-2

In a new study, researchers used an antibody discovery technology to identify a new potently neutralizing antibody with a unique mode of SARS-CoV-2 recognition. They reported their results on the bioRxiv preprint server.

18 May 2021

Study reveals the first complete 3D molecular structure of immature flavivirus

Better designed vaccines for insect-spread viruses like dengue and Zika are likely after researchers discovered models of immature flavivirus particles were originally misinterpreted.

17 May 2021

SARS-CoV-2 Nsp2 structure revealed by cryo-EM and AI

Researchers in the United States analyzed the non-structural protein 2 (Nsp2) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in order to better understand its function and to guide future drug discovery. The research paper is currently available on bioRxiv* preprint server.

16 May 2021

Phosphatidic acid is a key common substrate for hepatitis C and SARS-CoV-2 replication

A new study, released as a preprint on the bioRxiv* server, focuses on the lipid molecule called phosphatidic acid (PA), showing its crucial role in the replication of this virus, and thus its potential as a target for therapeutic intervention.

13 May 2021

Study reports new monoclonal antibodies with broad neutralizing capabilities against betacoronaviruses (including SARS-CoV-2)

In a paper published on the bioRxiv* preprint server, researchers report new monoclonal antibodies that target the S2 subunit and that have broad neutralization activity against several betacoronaviruses.

13 May 2021

New findings challenge the decades-old working mechanism of the hearing organ

Researchers at Linköping University, Sweden, have made several discoveries on the functioning mechanisms of the inner hair cells of the ear, which convert sounds into nerve signals that are processed in the brain.

10 May 2021

Cryptic pocket on the surface of SARS-CoV-2 may be a promising treatment target

In a new study currently available on the bioRxiv* preprint server, a multinational group of researchers modeled an entire membrane-embedded spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and highlighted the potential of a specific mapping approach for unveiling cryptic, potentially druggable pockets on the viral surface.

7 May 2021

Texas A&M AgriLife receives grant to support research on bacteriophage therapy

The National Institute of Allergy and Infectious Diseases, NIAID, part of the National Institutes of Health, NIH, has awarded $2.5 million in grants to support research on bacteriophage therapy, and Texas A&M AgriLife Research is among the grant recipients.

29 Apr 2021

Potent monoclonal antibody shows promise against emerging SARS-CoV-2 variants of concern

In a new study currently available on the bioRxiv* preprint server, a group of US-based researchers developed a panel of neutralizing monoclonal antibodies against SARS-CoV-2 that can block viral attachment to cells – and pinpointed a specific one that can potently neutralize all tested variants of concern.

28 Apr 2021

COVID-19 donor antibodies show broad cross-reactivity against SARS-CoV-2 variants and related viruses

A new study reports on a set of antibodies from COVID-19 donor serum, which seems to be cross-reactive across multiple Sarbecoviruses, including the very similar SARS-CoV-2, SARS-CoV and Middle East Respiratory Syndrome (MERS)-CoV.

28 Apr 2021

SARS-CoV-2 recruits heme metabolites in antibody evasion

A research paper recently published in the journal Science Advances by Cherepanov et al. (April 22nd, 2021) demonstrated that the NTD binds to biliverdin, a product of heme catabolism, leading to enhanced antibody escape at physiologically relevant concentrations.

28 Apr 2021

Nanobodies neutralize SARS-CoV-2 in pre-clinical model

A team of Australian researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI), the Doherty Institute, and the Kirby Institute have identified neutralizing nanobody cocktails that block the SARS-CoV-2 virus from entering cells in pre-clinical models.

27 Apr 2021

Researchers discover elusive cell type in fish sensory organs

One of the evolutionary disadvantages for mammals, relative to other vertebrates like fish and chickens, is the inability to regenerate sensory hair cells.

26 Apr 2021

Electron Microscopy News and Research

Study reveals structural details of omega-3 fatty acid transport across the blood–brain barrier

A closer look at how COVID-19 damages human lungs

New atomic-level model helps explain how SARS-CoV-2 causes extensive lung damage

Researchers find natural metabolites help SARS-CoV-2 escape antibodies

Direct action of SARS-CoV-2 on organs may lead to exacerbated inflammatory response in pediatric patients

Scientists use an original approach to resolve the 3D structure of flaviviruses

Researchers discover cross-reactive coronavirus antibody triggered during COVID-19 infection

Potent antibody with unique genetic signature and spike recognition mechanism neutralizes SARS-CoV-2

Study reveals the first complete 3D molecular structure of immature flavivirus

SARS-CoV-2 Nsp2 structure revealed by cryo-EM and AI

Phosphatidic acid is a key common substrate for hepatitis C and SARS-CoV-2 replication

Study reports new monoclonal antibodies with broad neutralizing capabilities against betacoronaviruses (including SARS-CoV-2)

New findings challenge the decades-old working mechanism of the hearing organ

Cryptic pocket on the surface of SARS-CoV-2 may be a promising treatment target

Texas A&M AgriLife receives grant to support research on bacteriophage therapy

Potent monoclonal antibody shows promise against emerging SARS-CoV-2 variants of concern

COVID-19 donor antibodies show broad cross-reactivity against SARS-CoV-2 variants and related viruses

SARS-CoV-2 recruits heme metabolites in antibody evasion

Nanobodies neutralize SARS-CoV-2 in pre-clinical model

Researchers discover elusive cell type in fish sensory organs

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