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Rice University researchers find new possibilities for benign, 'tunable' virus

Rice University scientists have designed a tunable virus that works like a safe deposit box. It takes two keys to open it and release its therapeutic cargo.

7 May 2014

New study explores how bacterial pathogen Yersinia tries to outsmart immune cell responses

A new study led by scientists at the University of Pennsylvania School of Veterinary Medicine has painted a clearer picture of the delicate arms race between the human immune system and a pathogen that seeks to infect and kill human cells.

6 May 2014

UNIGE researchers get closer to unraveling mystery of sexual ambiguity

A team of researchers from the University of Geneva (UNIGE) has been involved in a thorough genetic investigation based on the case of a child suffering from the Nivelon-Nivelon-Mabille Syndrome, a complex condition characterised mainly by a sexual development disorder.

6 May 2014

UH biomedical engineer receives ALR grant to study cause of lupus nephritis

In the U.S. alone, more than 1.5 million people have lupus, a chronic autoimmune disease in which the immune system turns against itself, attacking a person's healthy tissue, cells and organs. The symptoms can range from debilitating pain and fatigue to organ failure.

6 May 2014

Study reveals how ovarian cancer metabolism changes between early, late stages

A Rice University-led analysis of the metabolic profiles of hundreds of ovarian tumors has revealed a new test to determine whether ovarian cancer cells have the potential to metastasize, or spread to other parts of the body. The study also suggests how ovarian cancer treatments can be tailored based on the metabolic profile of a particular tumor.

6 May 2014

FABP5 protein enhances cognitive function

Case Western Reserve researchers have discovered that a protein previously implicated in disease plays such a positive role in learning and memory that it may someday contribute to cures of cognitive impairments.

5 May 2014

Researchers identify novel proceed to treat brittle bone disease

Researchers at Baylor College of Medicine have identified a new approach to treating brittle bone disease, a congenital disorder that results in fragile bones that break easily.

5 May 2014

Research: Novel therapeutic approach to overcome chemoresistance in ovarian cancer

Inhibiting enzymes that cause changes in gene expression could decrease chemotherapy resistance in ovarian cancer patients, researchers at Georgia State University and the University of Georgia say.

5 May 2014

Women with elevated levels of liver enzyme prior to pregnancy twice as likely to develop gestational diabetes

Women with high levels of a common liver enzyme measured prior to pregnancy were twice as likely to subsequently develop gestational diabetes than those with the lowest levels, according to a Kaiser Permanente study published today in the journal Diabetes Care.

5 May 2014

Johns Hopkins biochemists figure out HIV-fighting activity of enzyme

Johns Hopkins biochemists have figured out what is needed to activate and sustain the virus-fighting activity of an enzyme found in CD4+ T cells, the human immune cells infected by HIV. The discovery could launch a more effective strategy for preventing the spread of HIV in the body with drugs targeting this enzyme, they say.

2 May 2014

Isis Pharmaceuticals reports final data from ISIS-APOCIIIRx Phase 2 study in patients with FCS

Isis Pharmaceuticals, Inc. announced the final data from its Phase 2 study of ISIS-APOCIIIRx as a monotherapy in patients with familial chylomicronemia syndrome, or FCS.

2 May 2014

Scientists receive $2.3M grant to develop new technology to diagnose cancer, rheumatoid arthritis and colitis

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded a $2.3 million grant from the National Institute of General Medical Sciences of the National Institutes of Health to develop new technology to diagnose cancer, rheumatoid arthritis and colitis.

2 May 2014

Biotech to the rescue

MIT professor Ram Sasisekharan's three biotech companies — Momenta Pharmaceuticals, Cerulean Pharma, and Visterra — share a similar goal.

1 May 2014

University of Michigan scientists uncover how cells block mutation-causing activity of junk DNA

There's a civil war going on inside every one of the 37 trillion cells in your body. Now, University of Michigan scientists have uncovered how your cells keep this war from causing too much collateral damage.

26 Apr 2014

Study could lead to better understanding of how Notch protein directs healthy development of organs

Johns Hopkins researchers report they have figured out how the aptly named protein Botch blocks the signaling protein called Notch, which helps regulate development. In a report on the discovery, to appear online April 24 in the journal Cell Reports, the scientists say they expect the work to lead to a better understanding of how a single protein, Notch, directs actions needed for the healthy development of organs as diverse as brains and kidneys.

26 Apr 2014

Discovery offers potential target for reversing progression of end-stage liver disease

A team of researchers in the University of Arizona's College of Pharmacy has discovered a molecular pathway that could be key to creating new therapeutics that would slow or even reverse the progression of end-stage liver disease.

26 Apr 2014

MGH investigators develop next-generation genome editing system

A next-generation genome editing system developed by Massachusetts General Hospital investigators substantially decreases the risk of producing unwanted, off-target gene mutations. In a paper receiving online publication in Nature Biotechnology, the researchers report a new CRISPR-based RNA-guided nuclease technology that uses two guide RNAs, significantly reducing the chance of cutting through DNA strands at mismatched sites.

26 Apr 2014

Study reveals how human genome is protected from inadvertent import of viral RNA into cell

Scientists of the Max F. Perutz Laboratories of the University of Vienna and the Medical University of Vienna, together with colleagues of the ETH Zurich, have now shown how double stranded RNA, such as viral genetic information, is prevented from entering the nucleus of a cell.

23 Apr 2014

Johns Hopkins scientists find a way to prevent atherosclerosis

Working with mice and rabbits, Johns Hopkins scientists have found a way to block abnormal cholesterol production, transport and breakdown, successfully preventing the development of atherosclerosis, the main cause of heart attacks and strokes and the number-one cause of death among humans. The condition develops when fat builds inside blood vessels over time and renders them stiff, narrowed and hardened, greatly reducing their ability to feed oxygen-rich blood to the heart muscle and the brain.

23 Apr 2014

OGT releases new application note detailing performance of two DNA labelling kits

Oxford Gene Technology, The Molecular Genetics Company, has released a new application note detailing the technical evaluation of two DNA labelling kits, where OGT’s CytoSure Genomic DNA Labelling Kits were found to be quicker and more accurate than a leading alternative.

From Oxford Gene Technology 23 Apr 2014

Enzyme News and Research

Rice University researchers find new possibilities for benign, 'tunable' virus

New study explores how bacterial pathogen Yersinia tries to outsmart immune cell responses

UNIGE researchers get closer to unraveling mystery of sexual ambiguity

UH biomedical engineer receives ALR grant to study cause of lupus nephritis

Study reveals how ovarian cancer metabolism changes between early, late stages

FABP5 protein enhances cognitive function

Researchers identify novel proceed to treat brittle bone disease

Research: Novel therapeutic approach to overcome chemoresistance in ovarian cancer

Women with elevated levels of liver enzyme prior to pregnancy twice as likely to develop gestational diabetes

Johns Hopkins biochemists figure out HIV-fighting activity of enzyme

Isis Pharmaceuticals reports final data from ISIS-APOCIIIRx Phase 2 study in patients with FCS

Scientists receive $2.3M grant to develop new technology to diagnose cancer, rheumatoid arthritis and colitis

Biotech to the rescue

University of Michigan scientists uncover how cells block mutation-causing activity of junk DNA

Study could lead to better understanding of how Notch protein directs healthy development of organs

Discovery offers potential target for reversing progression of end-stage liver disease

MGH investigators develop next-generation genome editing system

Study reveals how human genome is protected from inadvertent import of viral RNA into cell

Johns Hopkins scientists find a way to prevent atherosclerosis

OGT releases new application note detailing performance of two DNA labelling kits

Biochemistry eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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