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New study uncovers mechanism of drug resistance

The use of antibiotics is often considered among the most important advances in the treatment of human disease. Unfortunately, though, bacteria are finding ways to make a comeback. According to the Centers for Disease Control, more than two million people come down with antibiotic-resistant infections annually, and at least 23,000 die because their treatment can’t stop the infection. In addition, the pipeline for new antibiotics has grown dangerously thin.

21 Feb 2014

Support for progranulin role in bipolar disorder

Researchers have found reduced levels of plasma progranulin in patients with bipolar disorder, strengthening evidence for its possible role as a biomarker for the condition.

20 Feb 2014

Researchers propose new treatment to prevent mucositis in cancer patients

Experimental work pointing to a therapy for alleviating mucositis -- a common, severe side effect of chemotherapy and irradiation of cancer patients or patients prepared for bone marrow transplantation - has been achieved by an international team of researchers from the US and Israel headed by scientists at the Hebrew University of Jerusalem.

20 Feb 2014

Researchers develop screening assay that quickly assesses nearly 1,500 compounds' effect on estrogen

A team of researchers at City of Hope has developed a screening assay that can quickly assess up to 1,536 compounds' effect on estrogen activity in the body. The test can also evaluate whether chemicals act as inhibitors of aromatase, an enzyme linked to breast cancer that converts androgen to estrogen.

20 Feb 2014

Purdue’s new innovation improves drug therapies by making real-time decisions about treatment options

Oncologists and cancer patients could improve the results of drug therapies by making real-time decisions about treatment options using an innovation developed in Purdue University's College of Pharmacy.

20 Feb 2014

Nanodiamond-drug embedded in contact lenses shows great promise for glaucoma treatment

By 2020, nearly 80 million people are expected to have glaucoma, a disorder of the eye that, if left untreated, can damage the optic nerve and eventually lead to blindness.

19 Feb 2014

Valproic acid metabolism and obesity: an interview with Dr. Namandjé Bumpus, Johns Hopkins Medicine

Valproic acid is one of the most widely prescribed drugs for the treatment of epilepsy. It has also been shown to be effective for the treatment of mood disorders and migraine headaches.

17 Feb 2014

Subtle epigenetic change plays important role in correct segregation of chromosomes

Abnormal number of chromosomes is often associated with cancer development. In a new study published in the journal Nature Structural and Molecular Biology researchers at Karolinska Institutet in Sweden have shown that a subtle epigenetic change plays an important role in the correct segregation of chromosomes.

17 Feb 2014

Children exposed to cigarette smoke may have lesser response to asthma treatment

Children exposed to cigarette smoke at home have lower levels of an enzyme that helps them respond to asthma treatment, a study has found.

17 Feb 2014

Researchers use new technique that can partially move tumors from inoperable locations in brain

One factor that makes glioblastoma cancers so difficult to treat is that malignant cells from the tumors spread throughout the brain by following nerve fibers and blood vessels to invade new locations.

17 Feb 2014

Research findings may help combat MRSA

A research team from Vanderbilt University Medical Center in Nashville, Tenn., is the first to decipher the 3-D structure of a protein that confers antibiotic resistance from one of the most worrisome disease agents: a strain of bacteria called methicillin-resistant Staphylococcus aureus (MRSA), which can cause skin and other infections. The Vanderbilt team's findings may be an important step in combatting the MRSA public health threat over the next 5 to 10 years.

17 Feb 2014

New study explores molecular biology and evolution of family of enzymes

For the ancient ancestors of plants and animals, a partnership with other microbes was once formed during an endosymbiotic event to give rise to eukaryotes. Plants and animals, over billions of years of trial and error, made efficient use of different energy sources in the environment, namely carbon dioxide and oxygen.

17 Feb 2014

Scientists discover novel antibody-based therapy that targets progression of kidney fibrosis

Scientists from the University of Sheffield have developed a novel antibody-based therapy which targets the progression of life threating kidney fibrosis.

16 Feb 2014

Research findings have important implications for personalized treatment of alcohol abuse

Heavy drinking is common in the United States and takes a personal and societal toll, with an annual estimated cost of $223.5 billion due to losses in workplace productivity, health care and criminal justice expenses.

16 Feb 2014

University of Liège joins IMI programme to develop new antibiotics against Gram-negative pathogens

More than 30 European universities and companies, led by GlaxoSmithKline, are joining forces in a six-year programme funded by the Innovative Medicines Initiative (IMI) for the sum of EUR 85 millions with the aim of developing new antibiotics against Gram-negative pathogens.

14 Feb 2014

Topiramate reduces drinking in patients committed to abstinence from alcohol

Heavy drinking alcohol consumption is common in the United States and takes a personal and societal toll, with an annual estimated cost of $223.5 billion due to losses in workplace productivity, and health care and criminal justice expenses.

14 Feb 2014

Researchers discover how beneficial bacteria in guts communicate with own cells

Communication is vital to any successful relationship. Researchers from the Institute of Food Research and the University of East Anglia have discovered how the beneficial bacteria in our guts communicate with our own cells.

14 Feb 2014

Researchers reveal how genome-editing tool works as 'guided missile' to correct errors in genetic code

Researchers from the Broad Institute and MIT have teamed up with colleagues from the University of Tokyo to form the first high definition picture of the Cas9 complex - a key part of the CRISPR-Cas system used by scientists as a genome-editing tool to silence genes and probe the biology of cells. Their findings, which are reported this week in Cell, are expected to help researchers refine and further engineer the tool to accelerate genomic research and bring the technology closer to use in the treatment of human genetic disease.

13 Feb 2014

Study uncovers how gut bacteria metabolize complex dietary carbohydrates in fruits, vegetables

We are all aware of the health benefits of dietary fiber. But what is dietary fiber and how do we metabolize it?

13 Feb 2014

LA BioMed researchers test investigational drug for treatment of Sanfilippo B syndrome

A promising new therapy has - for the first time - reduced damage to the brain that can be caused by Sanfilippo B (MPS IIIB), a rare and devastating genetic disease, Los Angeles Biomedical Research Institute researchers will report today in a presentation at the Lysosomal Disease Network's 10th Annual WORLD Symposium-.

12 Feb 2014

Enzyme News and Research

New study uncovers mechanism of drug resistance

Support for progranulin role in bipolar disorder

Researchers propose new treatment to prevent mucositis in cancer patients

Researchers develop screening assay that quickly assesses nearly 1,500 compounds' effect on estrogen

Purdue’s new innovation improves drug therapies by making real-time decisions about treatment options

Nanodiamond-drug embedded in contact lenses shows great promise for glaucoma treatment

Valproic acid metabolism and obesity: an interview with Dr. Namandjé Bumpus, Johns Hopkins Medicine

Subtle epigenetic change plays important role in correct segregation of chromosomes

Children exposed to cigarette smoke may have lesser response to asthma treatment

Researchers use new technique that can partially move tumors from inoperable locations in brain

Research findings may help combat MRSA

New study explores molecular biology and evolution of family of enzymes

Scientists discover novel antibody-based therapy that targets progression of kidney fibrosis

Research findings have important implications for personalized treatment of alcohol abuse

University of Liège joins IMI programme to develop new antibiotics against Gram-negative pathogens

Topiramate reduces drinking in patients committed to abstinence from alcohol

Researchers discover how beneficial bacteria in guts communicate with own cells

Researchers reveal how genome-editing tool works as 'guided missile' to correct errors in genetic code

Study uncovers how gut bacteria metabolize complex dietary carbohydrates in fruits, vegetables

LA BioMed researchers test investigational drug for treatment of Sanfilippo B syndrome

Biochemistry eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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