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Epigenetic changes drive successful metastases of pancreatic cancer cells

Epigenetic changes drive successful metastases of pancreatic cancer cells

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells. [More]
Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Researchers explore how metastatic pancreatic cancer gets ‘reprogrammed’ for optimal malignancy

Metastatic pancreatic cancer -- cancer that has spread from the pancreas to other tissues and is responsible for most patient deaths -- changes its metabolism and is "reprogrammed" for optimal malignancy, according to new findings reported Jan. 16 in Nature Genetics. [More]
Epigenetic modification may be cause of adult throat cancers linked to alcohol, tobacco use

Epigenetic modification may be cause of adult throat cancers linked to alcohol, tobacco use

A team of researchers at the Research Institute of the McGill University Health Centre has found an epigenetic modification that might be the cause of 15% of adult cancers of the throat linked to alcohol and tobacco use. [More]
Epigenetic changes favor development of fatty liver in humans and mice

Epigenetic changes favor development of fatty liver in humans and mice

Mice with a strong tendency to obesity already exhibit epigenetic changes at six weeks of age, inducing the liver to amplify its production of the enzyme DPP4 and release it into the circulation. Over the long term, this favors the development of a fatty liver. [More]
High BMI leads to epigenetic changes, study shows

High BMI leads to epigenetic changes, study shows

The extra pounds you gain during the holidays will not only show up on your hips but will also affect your DNA. [More]
Research sheds new light on key drivers of cancer metastasis

Research sheds new light on key drivers of cancer metastasis

Latest research from New Zealand's University of Otago is shedding new light on why and how cancer cells spread from primary tumours to other parts of the body. This phenomenon - known as metastasis - causes about 90 per cent of all cancer deaths. [More]
Low-carbohydrate diet may help reverse inherited intellectual disability linked to Kabuki syndrome

Low-carbohydrate diet may help reverse inherited intellectual disability linked to Kabuki syndrome

Experimenting on mice with a genetic change similar to that found in people with a rare inherited disease called Kabuki syndrome, Johns Hopkins scientists report that a very low-carbohydrate diet can "open up" DNA and improve mental function. [More]
U-M awarded NIH grant to investigate molecular changes that occur during and after physical activity

U-M awarded NIH grant to investigate molecular changes that occur during and after physical activity

The University of Michigan was recently awarded $8.2 million from the National Institutes of Health to investigate the molecular changes that occur during and after physical activity. [More]
Scientists uncover changes in immediate environment of DNA after fertilization

Scientists uncover changes in immediate environment of DNA after fertilization

A team of scientists at the Helmholtz Zentrum München shows changes in the immediate environment of DNA after the ovum and sperm fuse to form the zygote. The results suggest why all conceivable somatic cells can develop from the germ cells. The study has been published in the journal 'Genes and Development'. [More]
Researchers uncover how molecular switches control gene activity in human embryonic stem cells

Researchers uncover how molecular switches control gene activity in human embryonic stem cells

Researchers at the Babraham Institute have revealed a new understanding of the molecular switches that control gene activity in human embryonic stem cells. [More]
Researchers uncover new prognostic marker and possible therapeutic target for Ewing's sarcoma

Researchers uncover new prognostic marker and possible therapeutic target for Ewing's sarcoma

Researchers of the Sarcoma research group of the Bellvitge Biomedical Research Institute, led by Dr. Òscar Martínez-Tirado, have first described the methylation profile of Ewing's sarcoma, a cancer of bone and soft tissues that mainly affects children and teenagers. [More]
Karolinska Institute biologist receives 2016 Naomi Berrie Award for excellence in diabetes research

Karolinska Institute biologist receives 2016 Naomi Berrie Award for excellence in diabetes research

Columbia University has awarded the 2016 Naomi Berrie Award for Outstanding Achievement in Diabetes Research to Peter Arner, MD, PhD, a Distinguished Professor in the Department of Medicine at the Karolinska Institute, whose studies on the turnover of fat tissue in the human body has revealed processes that contribute to obesity and diabetes. [More]
Study reveals how tumor cells turn into cancer stem cells to renew outbreaks

Study reveals how tumor cells turn into cancer stem cells to renew outbreaks

An international study led by scientists from the Crick Institute in London and the Hebrew University of Jerusalem revealed a survival mechanism in cancer cells that allows the disease to erupt again even after aggressive treatment. [More]
Scientists map reorganization of genetic material in cells using 3-D imaging technique

Scientists map reorganization of genetic material in cells using 3-D imaging technique

Scientists have mapped the reorganization of genetic material that takes place when a stem cell matures into a nerve cell. [More]
Researchers identify pathway that helps cancer cells to aggressively spread in the brain

Researchers identify pathway that helps cancer cells to aggressively spread in the brain

Glioblastoma multiforme remains the most common and highly lethal brain cancer and is known for its ability to relapse. [More]
Deficiency of tumor suppressor gene may allow brain cancer cells to survive outside niches

Deficiency of tumor suppressor gene may allow brain cancer cells to survive outside niches

Astronauts survive in space by wearing high-tech space suits. But how do brain cancer cells thrive when they migrate to inhospitable sites within the brain? [More]
Researchers discover set of immune proteins that facilitate long-lasting immunity against malaria

Researchers discover set of immune proteins that facilitate long-lasting immunity against malaria

Houston Methodist researchers have discovered a set of immune proteins that facilitate long-lasting immunity against malaria. [More]
Smoking causes added mutations in DNA of lung cells

Smoking causes added mutations in DNA of lung cells

A paper published today in Science shows that smoking tobacco causes added mutations in the DNA of lung cells and in the DNA of other cells in the body. This is the first study to show the process by which smoking causes these cancers. [More]
Research findings may lead to new treatment option for ovarian cancer

Research findings may lead to new treatment option for ovarian cancer

A new study has identified an effective combination therapy for treating ovarian cancer cells. [More]
New edition of Nurturing Natures gets right to the heart of children's emotional development

New edition of Nurturing Natures gets right to the heart of children's emotional development

This new edition of the bestselling text, Nurturing Natures, provides an indispensable synthesis of the latest scientific knowledge about children's emotional development. [More]
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