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Study discovers microRNA signatures that could predict prognosis, distant metastasis in colorectal cancer

Study discovers microRNA signatures that could predict prognosis, distant metastasis in colorectal cancer

A new study developed at the Center for Gastrointestinal Cancer Research and the Center for Epigenetics, Cancer Prevention and Cancer Genomics at Baylor Research Institute has discovered unique metastasis-specific microRNA signatures in primary colorectal cancers that could predict prognosis and distant metastasis in colorectal cancer. [More]
NEB announces introduction of one-step cloning and multiple DNA fragment assembly

NEB announces introduction of one-step cloning and multiple DNA fragment assembly

New England Biolabs announces the introduction of the NEBuilder HiFi DNA Assembly Cloning Kit and Master Mix for one-step cloning and multiple DNA fragment assembly in as little as 15 minutes. [More]
Kyowa Hakko Kirin and Syndax sign agreement to develop entinostat in Japan and Korea

Kyowa Hakko Kirin and Syndax sign agreement to develop entinostat in Japan and Korea

Kyowa Hakko Kirin Co., Ltd., (Headquarters: Chiyoda-ku, Tokyo; president and CEO: Nobuo Hanai, "Kyowa Hakko Kirin") and Syndax Pharmaceuticals, Inc., (Waltham, Mass.; president and CEO: Arlene M. Morris, "Syndax") today jointly announced that the companies have entered into a license agreement for the exclusive rights to develop and commercialize entinostat in Japan and Korea. [More]
Research may provide new route to prevention and treatment of diabetes

Research may provide new route to prevention and treatment of diabetes

An analysis of the genomes and epigenomes of lean and obese mice and humans has turned up a wealth of clues about how genes and the environment conspire to trigger diabetes, Johns Hopkins researchers say. [More]
Offspring of mice treated with drug had delayed onset, reduced symptoms of Huntington's disease

Offspring of mice treated with drug had delayed onset, reduced symptoms of Huntington's disease

Famine, drug abuse and even stress can "silence" certain genes, causing health problems in generations to come. Now scientists are wondering—could therapies that change gene expression in parents help their children? [More]
Porvair Sciences releases 2015 catalogue of tissue culture plastics and epigenetic consumables

Porvair Sciences releases 2015 catalogue of tissue culture plastics and epigenetic consumables

Porvair Sciences has released a new 2015 catalogue that describes its popular range of high quality tissue culture treated plastics and consumable products for Epigenetics. [More]
Broccoli can help reduce HGPS-related defects

Broccoli can help reduce HGPS-related defects

Children who suffer from Hutchinson-Gilford Progeria syndrome age prematurely due to a defective protein in their cells. Scientists at Technische Universität München have now identified another important pathological factor: the system responsible for removing cellular debris and for breaking down defective proteins operates at lower levels in HGPS cells than in normal cells. The researchers have succeeded in reactivating protein breakdown in HGPS cells and thus reducing disease-related defects by using a substance from broccoli. [More]
Researchers uncover mechanism that helps white fat cells to become browner

Researchers uncover mechanism that helps white fat cells to become browner

White adipose tissue stores excess calories as fat that can be released for use in other organs during fasting. Mammals also have small amounts of brown adipose tissue, which primarily acts as an effective fat burner for the production of heat. Now researchers from the University of Southern Denmark have uncovered the mechanism by which white fat cells from humans gets reprogrammed to become browner. [More]
Study: Long-term endurance training alters epigenetic pattern in the human skeletal muscle

Study: Long-term endurance training alters epigenetic pattern in the human skeletal muscle

A new study from Karolinska Institutet in Sweden shows that long-term endurance training in a stable way alters the epigenetic pattern in the human skeletal muscle. The research team behind the study, which is being published in the journal Epigenetics, also found strong links between these altered epigenetic patterns and the activity in genes controlling improved metabolism and inflammation. [More]
Study finds that disarray in methylation helps tumors adapt to changing circumstances

Study finds that disarray in methylation helps tumors adapt to changing circumstances

The genetic tumult within cancerous tumors is more than matched by the disorder in one of the mechanisms for switching cells' genes on and off, scientists at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard report in a new study. [More]
Growth genes seem different in Hunger Winter children

Growth genes seem different in Hunger Winter children

Individuals conceived in the severe Dutch Famine, also called the Hunger Winter, may have adjusted to this horrendous period of World War II by making adaptations to how active their DNA is. Genes involved in growth and development were differentially regulated, according to researchers at the Leiden University Medical Center, Harvard University, and Columbia University's Mailman School of Public Health. [More]
DFG to establish eight new Collaborative Research Centres

DFG to establish eight new Collaborative Research Centres

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) will establish eight new Collaborative Research Centres (CRCs). [More]
DFG to establish new Collaborative Research Centres

DFG to establish new Collaborative Research Centres

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) will establish eight new Collaborative Research Centres (CRCs). [More]
Choosing the best way to verify the quality and quantity of Chromatin Immunoprecipitation DNA

Choosing the best way to verify the quality and quantity of Chromatin Immunoprecipitation DNA

Porvair Sciences has published a new guide to help laboratories choose the best way to verify the quality and quantity of their Chromatin Immunoprecipitation (ChIP) DNA. [More]
Effecting changes to FosB gene could help control addiction, depression

Effecting changes to FosB gene could help control addiction, depression

Regulation of a single, specific gene in a brain region related to drug addiction and depression is sufficient to reduce drug and stress responses, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published October 27 online in the journal Nature Neuroscience. [More]
High-absorption BCM-95 Curcumin can reduce spread of cancer cells

High-absorption BCM-95 Curcumin can reduce spread of cancer cells

A recently published cellular study on colorectal cancer showed that high-absorption BCM-95 Curcumin is able to reduce the spread of cancer cells and potentially increase the effectiveness of chemotherapy in the treatment of advanced colon cancer. [More]
Effects of unhealthy lifestyle persist even after atherosclerosis treatment

Effects of unhealthy lifestyle persist even after atherosclerosis treatment

Almost everyone knows that improving your eating habits will most likely improve your health. What most people may not know, however, is that the effects of poor eating habits persist long after dietary habits are improved. In a new report appearing in the November 2014 issue of the Journal of Leukocyte Biology, scientists use mice to show that even after successful treatment of atherosclerosis (including lowering of blood cholesterol and a change in dietary habits) the effects of an unhealthy lifestyle still affect the way the immune system functions. [More]
Douglas Mental Health University Institute researcher wins 2014 Wilder-Penfield prize

Douglas Mental Health University Institute researcher wins 2014 Wilder-Penfield prize

The Douglas Mental Health University Institute is proud to announce that its researcher and neurobiologist, Michael Meaney, C.M., Ph.D., C.Q., FRSC, is the 2014 laureate of the prestigious prix Wilder-Penfield. [More]
Epicure project: an interview with Frédéric Cren

Epicure project: an interview with Frédéric Cren

Epicure is a project led by Inventiva and Institut Curie that aims to deliver pre-clinical candidates on two novel epigenetic targets that have been selected due to their potential to activate immune responses against cancer cells. In addition one of these two targets has potential in respiratory indications such as asthma or COPD. [More]
InSilico Medicine, CCARL collaborate to improve personalized medicine projects in multiple sclerosis

InSilico Medicine, CCARL collaborate to improve personalized medicine projects in multiple sclerosis

InSilico Medicine, the company focused on drug discovery for cancer and age-related diseases, announced its investment in a research collaboration with Canada Cancer and Aging Research Laboratories, Inc. The companies will collaborate on improving decision making in clinical oncology and discovery, and personalized medicine projects in multiple sclerosis (MS). [More]