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Duke researchers discover blood markers linked to drug-resistant tumor cells

Duke researchers discover blood markers linked to drug-resistant tumor cells

While searching for a non-invasive way to detect prostate cancer cells circulating in blood, Duke Cancer Institute researchers have identified some blood markers associated with tumor resistance to two common hormone therapies. [More]
Researchers find switch that helps restore damaged axons

Researchers find switch that helps restore damaged axons

Researchers at the University of Wisconsin-Madison have found a switch that redirects helper cells in the peripheral nervous system into "repair" mode, a form that restores damaged axons. [More]
Parental psychiatric diseases may lead to risk for suicide attempts and violent offending by children

Parental psychiatric diseases may lead to risk for suicide attempts and violent offending by children

Risk for suicide attempts and violent offending by children appears to be associated with their parents' psychiatric disorders, according to an article published online by JAMA Psychiatry. [More]
Newly-developed epigenetic test can be used to identify tumors responsible for metastasis in cancer patient

Newly-developed epigenetic test can be used to identify tumors responsible for metastasis in cancer patient

In patients with cancer, initial diagnosis most often includes the detection of the primary or original tumor and the presence or absence of metastases, ie cells from the original tumor that have escaped from their original location and are growing into other tissues of the patient. [More]
Protein complex could play key role in natural development of stem cells into healthy blood cells

Protein complex could play key role in natural development of stem cells into healthy blood cells

A group of proteins best known for helping to activate all mammalian genes has been found to play a particularly commanding role in the natural development of specialized stem cells into healthy blood cells, a process known as hematopoiesis. [More]
Study shows Latinos age more slowly at molecular level than other ethnic groups

Study shows Latinos age more slowly at molecular level than other ethnic groups

A new paper co-authored by a UC Santa Barbara researcher reveals that Latinos age at a slower rate than other ethnic groups. The findings, published in the current issue of Genome Biology, may one day help scientists understand how to slow the aging process for everyone. [More]
Colorectal tumors present epigenetic heterogeneity, study finds

Colorectal tumors present epigenetic heterogeneity, study finds

A new study led by Dr. Manel Esteller, Director of the Epigenetics and Cancer Biology Program of Bellvitge Biomedical Research Institute, ICREA researcher and Professor of Genetics at University of Barcelona discovers that colorectal tumors present epigenetic heterogeneity that relates to the clinical course of the disease. [More]
Latinos age more slowly than other ethnic groups, reveals UCLA study

Latinos age more slowly than other ethnic groups, reveals UCLA study

A UCLA study is the first to show that Latinos age at a slower rate than other ethnic groups. The findings, published in the current issue of Genome Biology, may one day help scientists understand how to slow the aging process for everyone. [More]
Novel PET radiotracer reveals epigenetic activity in the human brain for the first time

Novel PET radiotracer reveals epigenetic activity in the human brain for the first time

A novel PET radiotracer developed at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital is able for the first time to reveal epigenetic activity - the process that determines whether or not genes are expressed - within the human brain. [More]
New Sequins technology could help improve quality of genomic analysis

New Sequins technology could help improve quality of genomic analysis

Australian genomics researchers have announced the development of Sequins -- synthetic 'mirror' DNA sequences that reflect the human genome. [More]
New study analyzes evolution of epigenetic mechanisms from bacteria to humans

New study analyzes evolution of epigenetic mechanisms from bacteria to humans

After the emergence of single-celled organisms some billions of years ago, nature started experimenting with how to diversify gene function without changing the sequence of the DNA, such that the blue print remains conserved, but allows gene products to have different functions. [More]
ZMYND8 protein can suppress metastasis-linked genes in prostate cancer

ZMYND8 protein can suppress metastasis-linked genes in prostate cancer

Although it reads like European license plate number, a protein known as ZMYND8 has demonstrated its ability to block metastasis-linked genes in prostate cancer, according to a study at The University of Texas MD Anderson Cancer Center. [More]
Menopause and insomnia could make women age faster

Menopause and insomnia could make women age faster

Two UCLA studies reveal that menopause--and the insomnia that often accompanies it -- make women age faster. [More]
Inability to turn off genes in the brain can affect learning and memory

Inability to turn off genes in the brain can affect learning and memory

Every time you play a game of basketball, make a cup of coffee or flick on a light switch, you are turning on genes in your brain. These same genes typically are turned off when the activity ceases - but when that doesn't happen, damaging consequences can occur. [More]
Scientists discover key cellular mechanism behind side-effects of antipsychotics

Scientists discover key cellular mechanism behind side-effects of antipsychotics

Since their development in the 1950s, antipsychotic drugs have been widely used to treat psychoses and neuropsychiatric disorders like schizophrenia. A debilitating side-effect of these drugs called parkinsonism limits their efficacy. [More]
Itaconate can suppress pro-inflammatory activity of macrophages

Itaconate can suppress pro-inflammatory activity of macrophages

An international group of scientists from US, Canada, Germany and Russia has revealed a substance produced in humans that can suppress the pro-inflammatory activity of macrophages - specific cells of immune system. [More]
Study demonstrates epigenetic link between environment and pubertal onset in humans

Study demonstrates epigenetic link between environment and pubertal onset in humans

Danish researchers have discovered a possible epigenetic link between the environment and pubertal timing. [More]
Scientists detect gene networks likely to be shared by all CLL patients

Scientists detect gene networks likely to be shared by all CLL patients

Research, involving scientists and doctors at the University of Southampton and Royal Bournemouth Hospital, has identified a network of genes that are likely to be shared by all patients who have chronic lymphocytic leukaemia (CLL). [More]
Advances in epigenome sequencing technologies can allow comprehensive analysis of cancers

Advances in epigenome sequencing technologies can allow comprehensive analysis of cancers

An international research collaboration led by UCL scientists has developed ways to improve the quality and accuracy of information harvested from epigenome sequencing datasets in two new research papers published jointly in Nature Biotechnology and Nature Communications today. According to the studies, epigenome sequencing technologies can allow for more comprehensive analysis of cancers - a key component in the development of targeted approaches to combat cancer. [More]
HDAC inhibitors may help regulate alcoholism-induced anxiety

HDAC inhibitors may help regulate alcoholism-induced anxiety

Epigenetics is the study of changes in organisms caused by modifying gene expression - by alcohol, for example - rather than alteration of the genetic code itself. Recent evidence suggests that alcohol can inhibit activity of an enzyme called histone deacetylase (HDAC) in the amygdala, a brain region that is crucial for storing memories and regulating fear, anxiety, and other emotions. [More]
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