Fallopian Tube News and Research

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Pilot human trial uses new falloposcope device to capture images of fallopian tubes

Due to a lack of effective screening and diagnostic tools, more than three-fourths of ovarian cancer cases are not found until the cancer is in an advanced stage.

22 Jan 2022

Human iPSC-derived fallopian tube organoids reveal the origins of common ovarian cancer

Stem cell scientists have revealed the origins of a common ovarian cancer by modeling fallopian tube tissues, allowing them to characterize how a genetic mutation puts women at high risk for this cancer.

29 Dec 2021

Cancer registry offers a better understanding of ovarian granulosa cell tumors

Examination of Japanese cases of gynecological cancer offers a better understanding of the profile of a rare ovarian tumor and could change treatment guidelines.

4 Dec 2021

Active management strategy helps women with early, nonviable pregnancies of unknown location

Women with early, nonviable pregnancies of unknown location who were given an active management strategy had more successful pregnancy resolutions than those given an expectant management strategy, according to a recent clinical trial published in JAMA.

13 Sep 2021

NIH-funded study examines most effective treatment option for pregnancy of unknown location

Preemptive treatment for a nonviable pregnancy of unknown location—a situation in which there is a positive pregnancy test result but the location of the pregnancy cannot be confirmed within or outside the uterus with other diagnostic tests—resolves the condition more rapidly than treating symptoms as they arise, suggests a study supported by the National Institutes of Health.

3 Aug 2021

Eggs and embryos go through a more dynamic and complex journey than previously thought

The journey of the egg and the embryo through the fallopian tube or oviduct toward the uterus is not well understood, mainly because it is inaccessible for direct imaging.

14 Jul 2021

Female reproductive organs not susceptible to direct SARS-CoV-2 infection

Researchers at the University in San Francisco, California, report that coronavirus disease 2019 (COVID-19) is unlikely to negatively impact on pregnancy-related outcomes such as premature birth, transmission to babies via breast milk, and infertility.

23 Jun 2020

Researchers investigate the early development of ovarian cancer

Researchers from the group of Hans Clevers at the Hubrecht Institute have modeled the development and progression of high-grade serous ovarian cancer in mini-versions of the female reproductive organs of the mouse.

27 May 2020

Study could help identify more targeted treatments for ovarian cancer

The rogue cellular engine that drives a majority of ovarian cancers remains frustratingly difficult to disable. A new study comparing cancerous tissue with normal fallopian tube samples advances important insights about this machinery and confirms biological hallmarks of survival.

20 May 2020

ACE2-TMPRSS2 profiling indicates tissue vulnerability to SARS-CoV-2 infection

A new study published in April 2020 on the preprint server bioRxiv reports that the different levels of susceptibility of various organs to viral attack by the SARS-CoV-2 virus causing the huge pandemic of COVID-19 sweeping around the world can be predicted from the level of expression of two molecules, the ACE2 receptor, and the TMPRSS2 protein.

20 Apr 2020

New quick and convenient microfluidic chip to assess male fertility

Current tests for male fertility include measuring the concentration and motility of spermatozoa. However, other characteristics of sperm, such as their ability to follow a chemical trail to the egg, can influence the likelihood of fertilization.

19 Feb 2020

Autophagy genes work against tumors in some ovarian cancers

Shedding light on a decades-old controversy, scientists at the Medical University of South Carolina and University of California at San Diego published findings in PLOS Genetics this month showing that autophagy or "self-eating" genes work against tumors in certain types of ovarian cancer.

13 Feb 2020

Secondary surgery for recurrent ovarian cancer patients does not result in longer survival

Researchers from The University of Texas MD Anderson Cancer Center reported that secondary tumor-reduction, or cytoreduction, surgery followed by chemotherapy did not result in longer survival than chemotherapy alone in patients with platinum-sensitive recurrent ovarian cancer.

13 Nov 2019

PARP inhibitor combined with chemotherapy increases survival for newly diagnosed ovarian cancer patients

Researchers from The University of Texas MD Anderson Cancer Center reported study results showing that initial treatment with the PARP inhibitor veliparib in combination with chemotherapy significantly increased progression-free survival for patients with newly diagnosed, metastatic high-grade serous ovarian cancer, according to the results of the VELIA trial.

28 Sep 2019

Management of ovarian cancer risk in women with BRCA1/2 gene mutations

A new review to help physicians manage the risk of ovarian cancer in women who carry the BRCA1/2 gene mutations is published in CMAJ.

12 Aug 2019

New protein target for deadly ovarian cancer

A new study shows that targeting a specific protein found within quickly spreading high-grade serous carcinomas (HGSC) of the ovary could help contain these cancers. HGSC is the most common and deadly form of epithelial ovarian cancer, which is itself the deadliest cancer of the female reproductive tract.

14 Jul 2019

New anti-HER2 drug shows promising anti-tumor activity in gullet, stomach and bowel cancers

An antibody that binds simultaneously to two distinct regions of the HER2 receptor to block the growth of cancer cells has shown promising signs of anti-tumor activity in a number of cancers including those of the gullet (esophagus), stomach and bowel.

14 Nov 2018

Maintenance therapy with olaparib improves progression-free survival in advanced ovarian cancer patients

Two-year maintenance therapy with olaparib, a PARP (poly ADP ribose polymerase) inhibitor, olaparib, led to a substantial, unprecedented improvement in progression-free survival (PFS) in newly diagnosed patients with advanced ovarian cancer and a BRCA1 or 2 mutation, results from the phase 3 SOLO-1 trial show.

22 Oct 2018

LYNPARZA Phase III SOLO-1 results show improved outcome for patients with advanced BRCA-mutated ovarian cancer

AstraZeneca and Merck & Co., Inc., Kenilworth, N.J., today announced detailed results from the Phase III SOLO-1 trial testing LYNPARZA (olaparib) 300 mg tablets twice-daily as a maintenance treatment for patients with newly diagnosed advanced BRCA-mutated ovarian cancer who were in complete or partial response following 1st-line standard platinum-based chemotherapy.

22 Oct 2018

ImmunoGen announces study results of platinum-resistant ovarian cancer therapy at ESMO 2018 Congress

ImmunoGen, Inc., a leader in the expanding field of antibody-drug conjugates for the treatment of cancer, today announced initial safety and preliminary anti-tumor activity from the FORWARD II expansion cohort assessing mirvetuximab soravtansine in combination with Merck's anti-PD-1 therapy, KEYTRUDA (pembrolizumab).

22 Oct 2018

Fallopian Tube News and Research

Pilot human trial uses new falloposcope device to capture images of fallopian tubes

Human iPSC-derived fallopian tube organoids reveal the origins of common ovarian cancer

Cancer registry offers a better understanding of ovarian granulosa cell tumors

Active management strategy helps women with early, nonviable pregnancies of unknown location

NIH-funded study examines most effective treatment option for pregnancy of unknown location

Eggs and embryos go through a more dynamic and complex journey than previously thought

Female reproductive organs not susceptible to direct SARS-CoV-2 infection

Researchers investigate the early development of ovarian cancer

Study could help identify more targeted treatments for ovarian cancer

ACE2-TMPRSS2 profiling indicates tissue vulnerability to SARS-CoV-2 infection

New quick and convenient microfluidic chip to assess male fertility

Autophagy genes work against tumors in some ovarian cancers

Secondary surgery for recurrent ovarian cancer patients does not result in longer survival

PARP inhibitor combined with chemotherapy increases survival for newly diagnosed ovarian cancer patients

Management of ovarian cancer risk in women with BRCA1/2 gene mutations

New protein target for deadly ovarian cancer

New anti-HER2 drug shows promising anti-tumor activity in gullet, stomach and bowel cancers

Maintenance therapy with olaparib improves progression-free survival in advanced ovarian cancer patients

LYNPARZA Phase III SOLO-1 results show improved outcome for patients with advanced BRCA-mutated ovarian cancer

ImmunoGen announces study results of platinum-resistant ovarian cancer therapy at ESMO 2018 Congress

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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