Fibrosarcoma News and Research

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How the gut microbiome supports iron uptake by intestinal regulatory T-cells

Research paper discusses the relationship between iron deficiencies and immune tolerance in patients with inflammatory bowel disease. The study shows that high cellular iron levels fostered by pentanoate, a short-chain fatty acid produced by intestinal microbiota, are necessary for the homeostasis of regulatory T cells in the intestine, and iron deficiencies in Treg can result in lethal autoimmune disease.

17 May 2023

What is the potential role of sphingosine kinase inhibitors as antiviral agents?

In a new study, researchers explored sphingosine kinases inhibitors and characterized the role of SKs in Ebola virus (EBOV) entry.

16 Aug 2022

Lower, more frequent doses of nanomedicines may provide additional benefits for cancer patients

Tiny structures called nanoparticles can be used to carry substances to certain parts of the body-;for example, to deliver a chemotherapy drug to a tumor.

11 Mar 2022

Study: NTRK fusions are far more frequently seen in pediatric tumors

In a large study of pediatric cancer patients, researchers from Children's Hospital of Philadelphia have analyzed the frequency, fusion partners, and clinical outcome of neurotrophic tyrosine receptor kinase (NTRK) fusions, which are clinical biomarkers that identify patients suitable for treatment with FDA-approved TRK inhibitors.

16 Jan 2021

New type of adoptive cell therapy could target prostate and pancreatic cancers in humans

In experiments with mice, researchers at the Johns Hopkins Kimmel Cancer Center say they have slowed the growth of transplanted human prostate and pancreatic cancer cells by introducing bone marrow cells with a specific gene deletion to induce a novel immune response.

5 Mar 2020

Scientists use supercomputers to shed light on skin cancer formation mechanism

Skin cancer, particularly melanoma, which is the deadliest and most serious type of human skin cancer, begins as a small lesion or blemish. Usually, these blemishes start off as harmless accumulation of melanocytes, which give the skin its color. As the disease progresses, it can spread throughout the body.

18 Dec 2019

Revolutionary cancer drugs that target any tumor to be fast-tracked into hospitals by NHS

Patients in England could be some of the first in the world to be treated with revolutionary cancer drugs that can target any type of tumor.

19 Jun 2019

Research may pave way for development of potent weapons against cancer

Despite significant advances in cancer research, the disease continues to exact a devastating toll. Because cancer is a disease of the body's own cells, which mutate and develop under evolutionary pressure, conventional treatments like chemotherapy and radiation often leave behind a residue of resistant cells that go on to expand and wreak havoc.

27 Nov 2018

FDA grants accelerated approval to oncology drug for treatment of key genetic driver of cancer

The U.S. Food and Drug Administration today granted accelerated approval to Vitrakvi (larotrectinib), a treatment for adult and pediatric patients whose cancers have a specific genetic feature (biomarker).

27 Nov 2018

Scientists discover genetic causes underlying group of related infant cancers

The genetic causes of a group of related infant cancers have been discovered by scientists at the Wellcome Sanger Institute, the University of Wuerzburg and their collaborators.

18 Jun 2018

First-of-its-kind cancer drug effective in 93% of pediatric patients

A first-of-its-kind drug targeting a fused gene found in many types of cancer was effective in 93 percent of pediatric patients tested, researchers at UT Southwestern's Simmons Cancer Center announced.

30 Mar 2018

New TSRI study may provide chance to target tumors before metastasis

New research from The Scripps Research Institute may give scientists a chance to target tumors before they metastasize.

9 Feb 2018

New targeted oral therapy results in durable responses across many kinds of cancer

Scientists may have developed the first targeted, oral, tumor-type agnostic therapy - a cancer medicine that works comparably well across many kinds of cancer, regardless of patient age. In clinical trials of adults and children with 17 different types of advanced cancer, larotrectinib treatment resulted in responses in 76% of patients.

5 Jun 2017

TSRI study reveals clues to where tumor metastases are born

Scientists at The Scripps Research Institute have discovered why some cancers may reoccur after years in remission.

3 May 2017

Researchers identify novel molecular mechanism involved in progression, metastasis of TNBC

University of Tsukuba-led researchers identified a novel molecular mechanism involved in progression and metastasis in the most aggressive form of breast cancer.

21 Apr 2017

Research finds differences in cell migration between normal and malignant tumor cells

What makes cancer so deadly is its ability to move . The better that doctors can keep tumors contained and protect unaffected organs in the body, the less lethal a cancer will be.

21 Dec 2016

Nanomechanical microcantilevers can quickly detect mutations in patients with malignant melanoma

Changes in the genetic make-up of tissue samples can be detected quickly and easily using a new method based on nanotechnology.

6 Sep 2016

Experimental treatment shrinks rare pediatric tumor by 90%

When a baby's life was threatened by a rare pediatric cancer that would not respond to surgery or chemotherapy, doctors at Nemours Children's Hospital rapidly, successfully shrank the tumor by 90 percent using an experimental treatment, according to a new study published online in Pediatric Blood and Cancer.

20 Apr 2016

Experimental drugs that modify cell metabolism also halt tumor growth

Experimental drugs that alter cell metabolism also halted tumor growth and extended survival in mice with cancers linked to changes in the same gene, according to a new study led by researchers at NYU Langone Medical Center, its Laura and Isaac Perlmutter Cancer Center and Massachusetts General Hospital.

15 Dec 2015

Washington University researchers develop way to apply light-based therapy to reach deep tumors

Light long has been used to treat cancer. But phototherapy is only effective where light easily can reach, limiting its use to cancers of the skin and in areas accessible with an endoscope, such as the gastrointestinal tract.

12 Mar 2015