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Scientists discover nanoparticles can disrupt intracellular transport pathways

Scientists at the Centre of Cancer Biomedicine at the Norwegian Radium Hospital are the first to show that uptake and accumulation of nanoparticles in cells can disrupt important intracellular transport pathways.

24 Aug 2011

Radiolabeled protein reveals presence of S. aureus endocarditis in mouse model

A novel imaging probe developed by Massachusetts General Hospital (MGH) investigators may make it possible to diagnose accurately a dangerous infection of the heart valves.

22 Aug 2011

Large-scale population imaging reveals robust sparse coding in Drosophila mushroom body

A research team at Cold Spring Harbor Laboratory (CSHL) led by Assistant Professor Glenn Turner has published results of experiments that show large populations of neurons in the brains of living fruit flies responding simultaneously to a variety of odors.

19 Aug 2011

Two-color stimulated emission depletion microscopy in living cells

Researchers are able to achieve extremely high-resolution microscopy through a process known as stimulated emission depletion (STED) microscopy. This cutting-edge imaging system has pushed the performance of microscopes significantly past the classical limit, enabling them to image features that are even smaller than the wavelength of light used to study them.

18 Aug 2011

Inexpensive microcalorimeters can quickly detect TB

Researchers have discovered a faster, cheaper method for the diagnosis of tuberculosis (TB). A major barrier in TB prevention, especially in developing countries, is that diagnosis is slow and costly.

17 Aug 2011

G-CSF therapy does not induce chromosomal instability in healthy stem cell donors

According to a study published in Blood, the Journal of the American Society of Hematology (ASH), researchers have reported that administration of granulocyte colony-stimulating factor (G-CSF), a drug that releases stem cells from the bone marrow into the blood, is unlikely to put healthy stem cell donors at risk for later development of abnormalities involving loss or gains of chromosomes that have been linked to hematologic disorders such as myelodysplastic syndromes (MDS) and acute myeloid leukemia.

12 Aug 2011

MYCN amplification can serve as a favorable prognostic indicator for neuroblastoma

Neuroblastoma, a malignant tumor that primarily affects infants and young children, is a leading cause of death for children with cancer. When amplification of the MYCN oncogene is found in the tumor, it usually indicates an aggressive tumor with rapid progression of the disease and a poor outcome. Thus MYCN amplification has come to be used as a prognostic indicator.

12 Aug 2011

NPL scientists mimick the ways viruses infect human cells and deliver genetic material

Scientists at the National Physical Laboratory (NPL) have mimicked the ways viruses infect human cells and deliver their genetic material. The research hopes to apply the approach to gene therapy - a therapeutic strategy to correct defective genes such as those that cause cancer.

12 Aug 2011

New treatment uses lasers to stimulate stem cells and reduce heart scarring

After a heart attack or stroke, heart scarring can lead to dangerously paper-thin heart walls and a decreased ability to pump blood through the body. Although the heart is unable to completely heal itself, a new treatment developed at Tel Aviv University uses laser-treated bone marrow stem cells to help restore heart function and health.

11 Aug 2011

Novel link between two receptors mediates fungal recognition in macrophages

Whitehead Institute researchers have uncovered a novel association between two fungal recognition receptors on the surface of certain immune cells, called macrophages.

9 Aug 2011

Scientists identify small molecule inhibitors of cellular uptake

Scientists from Freie Universität Berlin and the NeuroCure Cluster of Excellence led by biochemist Volker Haucke in collaboration with colleagues from Australia and the Leibniz Institute for Molecular Pharmacology in Berlin have developed small molecules that inhibit the internalization of important signaling molecules but also of pathogenic organisms such as the immunodeficiency virus and bacteria into cells.

5 Aug 2011

Chromogenic in situ hybridization can identify ALK rearrangement in lung cancer patients

A relatively simple and inexpensive method may be used to determine whether a lung cancer patient is a candidate for crizotinib therapy, according to research published in the August issue of the Journal of Thoracic Oncology, the official monthly journal of the International Association for the Study of Lung Cancer.

3 Aug 2011

Pregnancy and electromagnetic fields linked to asthma in kids

According to American researchers, children whose mothers had high exposure to electromagnetic fields while pregnant may have an increased risk of developing asthma. Many prior studies have failed to consistently show that chronic exposure to electromagnetic fields - from power lines and appliances such as microwaves ovens, hair dryers and vacuum cleaners - are harmful to human health.

1 Aug 2011

New fluorescent tool can track mysterious workings of cellular RNAs

The ability to tag proteins with a green fluorescent light to watch how they behave inside cells so revolutionized the understanding of protein biology that it earned the scientific teams who developed the technique Nobel Prizes in 2008.

30 Jul 2011

NanoString introduces new assay for leukemia fusion gene analysis

NanoString Technologies, Inc., a privately held provider of life science tools for translational research and developer of molecular diagnostics, today announced the availability of a comprehensive multiplexed assay for the simple and cost-effective analysis of fusion genes linked to leukemia.

From NanoString Technologies 29 Jul 2011

New silicone chip could make genetic analysis far more sensitive, rapid, and cost-effective

UBC researchers have invented a silicone chip that could make genetic analysis far more sensitive, rapid, and cost-effective by allowing individual cells to fall into place like balls in a pinball machine.

27 Jul 2011

Lipid-based nanocarrier can improve cancer treatments

Scientists seeking to improve cancer treatments have created a tiny drug transporter that maximizes its ability to silence damaging genes by finding the equivalent of an expressway into a target cell.

27 Jul 2011

Maltodextrin-based imaging probes could improve diagnosis and treatment of bacterial infections

A new family of contrast agents that sneak into bacteria disguised as glucose food can detect bacterial infections in animals with high sensitivity and specificity. These agents -- called maltodextrin-based imaging probes -- can also distinguish a bacterial infection from other inflammatory conditions.

21 Jul 2011

Humans and zebrafish share mechanisms that regulate the circadian system

Circadian rhythms - the natural cycle that dictates our biological processes over a 24-hour day - does more than tell us when to sleep or wake. Disruptions in the cycle are also associated with depression, problems with weight control, jet lag and more. Now Prof. Yoav Gothilf of Tel Aviv University's Department of Neurobiology at the George S. Wise Faculty of Life Sciences is looking to the common zebrafish to learn more about how the human circadian system functions.

21 Jul 2011

IHD blood test for Alzheimer's disease yields 83% sensitivity and 82% specificity

Innovative Health Diagnostics (IHD), the innovative company specialising in the development of diagnostic blood tests for Alzheimer's disease and neurodegenerative illnesses presents its first clinical results for its IHD-Amy blood test for Alzheimer's disease.

18 Jul 2011

Fluorescence News and Research

Scientists discover nanoparticles can disrupt intracellular transport pathways

Radiolabeled protein reveals presence of S. aureus endocarditis in mouse model

Large-scale population imaging reveals robust sparse coding in Drosophila mushroom body

Two-color stimulated emission depletion microscopy in living cells

Inexpensive microcalorimeters can quickly detect TB

G-CSF therapy does not induce chromosomal instability in healthy stem cell donors

MYCN amplification can serve as a favorable prognostic indicator for neuroblastoma

NPL scientists mimick the ways viruses infect human cells and deliver genetic material

New treatment uses lasers to stimulate stem cells and reduce heart scarring

Novel link between two receptors mediates fungal recognition in macrophages

Scientists identify small molecule inhibitors of cellular uptake

Chromogenic in situ hybridization can identify ALK rearrangement in lung cancer patients

Pregnancy and electromagnetic fields linked to asthma in kids

New fluorescent tool can track mysterious workings of cellular RNAs

NanoString introduces new assay for leukemia fusion gene analysis

New silicone chip could make genetic analysis far more sensitive, rapid, and cost-effective

Lipid-based nanocarrier can improve cancer treatments

Maltodextrin-based imaging probes could improve diagnosis and treatment of bacterial infections

Humans and zebrafish share mechanisms that regulate the circadian system

IHD blood test for Alzheimer's disease yields 83% sensitivity and 82% specificity

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