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Fragile X Syndrome News and Research RSS Feed - Fragile X Syndrome News and Research

Fragile X syndrome is the most common form of inherited mental retardation. A problem with a specific gene causes the disease. Normally, the gene makes a protein you need for brain development. But the mutation causes a person to make little or none of the protein, which results in the symptoms of Fragile X.

Seaside Therapeutics commences STX107 Phase 1 clinical trial for Fragile X Syndrome

3. November 2009 05:18
Seaside Therapeutics LLC today announced that the Company has initiated a Phase 1 clinical trial of STX107, a highly potent, selective mGluR5 antagonist, in development for the treatment of Fragile X Syndrome. The single ascending dose study is designed to evaluate the safety, tolerability and pharmacokinetics of STX107 in healthy volunteers. Fragile X Syndrome is the most common inherited form of mental impairment and the most common known cause of autism. [More]

Phase 1 study of STX107 for Fragile X syndrome begins

3. November 2009 03:09
NIH-supported scientists at Seaside Therapeutics in Cambridge, Mass., are beginning a clinical trial of a potential medication designed to correct a central neurochemical defect underlying Fragile X syndrome, the most common inherited cause of intellectual disability. There has to date been no medication that could alter the disorder's neurologic abnormalities. The study will evaluate safety, tolerability, and optimal dosage in healthy volunteers. [More]

Report on a recent survey conducted on diagnostic labs

25. September 2009 06:43
From Kalorama Information a unique tool for assessing the diagnostic business today. Working in conjunction with premier diagnostic survey database Emmes Group, Kalorama Information presents the summarized results from a recent survey of a critical mass of diagnostic labs in the U.S, with analysis from Kalorama's leading diagnostic analyst, Shara Rosen. [More]

Chemists rationally design inhibitors against an RNA molecule that causes myotonic muscular dystrophy

9. August 2009 20:31
Chemists at the University at Buffalo have used rational drug design to synthesize small, cell-permeable molecules that are effective in vitro against two common types of myotonic muscular dystrophy, a result that has implications for potentially curing muscular dystrophy, as well as other diseases. [More]

National Institutes of Health develops research plan on Fragile X syndrome and associated disorders

20. July 2009 18:29
The National Institutes of Health has developed a research plan to advance the understanding of fragile X syndrome and its associated conditions, fragile X-associated tremor/ataxia syndrome and fragile X-associated primary ovarian insufficiency. Fragile X syndrome causes intellectual and developmental disabilities and results from a mutation in a gene on the X chromosome. [More]

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Measuring fragile X mental retardation

24. June 2009 05:06
Researchers from the University of California, Davis have developed a specific and quantitative means of measuring levels of the fragile X mental retardation 1 (FMR1) protein (FMRP), which is mutated in fragile X syndrome. The related report by Iwahashi et al, "A quantitative ELISA assay for the fragile X mental retardation 1 protein," appears in the July 2009 issue of the Journal of Molecular Diagnostics. [More]

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Small molecules might block mutant protein production in Huntington's disease

5. May 2009 19:03
Molecules that selectively interfere with protein production can stop human cells from making the abnormal molecules that cause Huntington's disease, researchers at UT Southwestern Medical Center have found. [More]

Small molecules might block mutant protein production in Huntington's disease

3. May 2009 20:24
Molecules that selectively interfere with protein production can stop human cells from making the abnormal molecules that cause Huntington's disease, researchers at UT Southwestern Medical Center have found. [More]

Melatonin medication helpful for sleep problems in children with autism, Fragile X syndrome

15. April 2009 21:47
A study in the April 15 issue of the Journal of Clinical Sleep Medicine determined that over-the-counter melatonin medication can shorted the length of time it takes for children with autistic spectrum disorder (ASD), Fragile X Syndrome (FXS), or both to fall asleep at the beginning of the night. [More]

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Guidance for evaluating menopause-like condition in girls and young women

5. February 2009 04:23
A comprehensive plan to help health care professionals diagnose and treat primary ovarian insufficiency-a menopause-like condition affecting girls and young women that may occur years before normal menopause is expected-has been developed by a scientist at the National Institutes of Health. [More]

Discovery of the novel Fragile X granule could lead to new autism treatment

5. February 2009 03:44
A Brown University research team has discovered something in the brain that could serve as a target for future autism and mental retardation treatments. [More]

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Sociability traced to region of brain called amygdala

29. January 2009 10:33
People with a genetic condition called Williams syndrome are famously gregarious. Scientists, looking carefully at brain function in individuals with Williams syndrome, think they may know why this is so. [More]

Biologists discover link between CGG repeats in DNA and neurological disorders

12. January 2009 21:30
Researchers have long known that some repetitive DNA sequences can make human chromosomes "fragile," i.e. appearing constricted or even broken during cell divisions. [More]

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New drug being tested for Fragile X syndrome

6. January 2009 22:04
A pilot trial of an oral drug therapy called fenobam has shown promising initial results and could be a potential new treatment option for adult patients with Fragile X syndrome (FXS). [More]

New system of scoring IQ tests taken by children with fragile X syndrome

16. December 2008 21:14
Parents of children with intellectual disabilities have long been frustrated by intelligence quotient (IQ) testing that tells them little to nothing about the long-term learning potential of their children. [More]

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