Frontotemporal Dementia News and Research

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Suberoylanilide hydroxamic acid holds promise against familial frontotemporal dementia

A drug already approved for people with cancer shows early potential as a therapy for a common form of dementia, UT Southwestern Medical Center researchers report.

1 Jun 2011

Many patients receive an incorrect dementia diagnosis: Lund study

Many patients receive an incorrect dementia diagnosis. This is shown by a study carried out by neuropathology researchers in Lund, Sweden.

31 May 2011

Proteostasis acquires Harvard University's two novel protein target licenses

Proteostasis Therapeutics announced today that it has acquired two exclusive licenses from Harvard University to technologies for enhancing the activity of a key cellular protein clearance mechanism, the ubiquitin-proteasome pathway.

27 Apr 2011

Sarcasm and lie detection failure signals dementia: Study

Researchers have found that inability to recognize others' insincerity, lies and sarcasm could be a warning sign of a form of dementia. They found that people with frontotemporal dementia - a type of dementia that affects the frontal and temporal lobes of the brain - often lose the ability to detect sarcasm and lies, while people who grow older normally don't experience this.

17 Apr 2011

Person's inability to understand sarcasm and lies can be a warning sign of dementia

By asking a group of older adults to analyze videos of other people conversing -- some talking truthfully, some insincerely -- a group of scientists at the University of California, San Francisco has determined which areas of the brain govern a person's ability to detect sarcasm and lies.

16 Apr 2011

Malarial drugs may help treat specific form of frontotemporal dementia

Frontotemporal dementia is caused by a breakdown of nerve cells in the frontal and temporal region of the brain, which leads to, among other symptoms, a change in personality and behavior. The cause of some forms of frontotemporal dementia is a genetically determined reduction of a hormone-like growth factor, progranulin.

3 Feb 2011

Common psychiatric drugs could slow dementia

Researchers say commonly used psychiatric drugs could be effective in slowing the progression of certain types of dementia. Dr John Kwok and colleagues from Neuroscience Research Australia have discovered a mutant gene that causes abnormal proteins build up in the brains of people with frontotemporal dementia, a disease that affects people in their 50s and 60s.

28 Oct 2010

Career choice may influence where dementia takes root in the brain: Study

In an international study of patients with a devastating type of dementia that often strikes in middle age, researchers have found intriguing evidence that career choice may influence where the disease takes root in the brain.

23 Sep 2010

New research studies presented at Alzheimer's Association International Conference

The primary therapeutic target in Alzheimer's disease has been the beta amyloid peptide, which clusters outside cells in the brain to form sticky clumps known as plaques. Recently, more attention has been given to the tau protein, which aggregates inside the brain cells of people with Alzheimer's, forming neurofibrillary tangles. Precisely how these proteins interact in causing the disease is unclear.

14 Jul 2010

Scientist leads global discussion, research on insula

A scientist at Barrow Neurological Institute is leading the global discussion and research on a hidden lobe of the brain called the insula. A.D. "Bud" Craig, PhD, who began studying the often-ignored lobe more than two decades ago, has organized and edited a special edition of the journal Brain Structure and Function dedicated to the emerging medical and scientific interest in the insula.

8 Jul 2010

ISB, GIND collaborate on whole-genome sequencing to identify drug targets for Huntington's Disease

The Institute for Systems Biology (ISB) of Seattle, WA, is collaborating with the Gladstone Institute of Neurological Disease (GIND) and its Taube-Koret Center for Huntington's Disease Research to use whole-genome sequencing to identify genes and novel drug targets related to the onset and progression of Huntington's disease (HD). The research team, led by GIND associate director and senior investigator Steven Finkbeiner, MD, PhD, will also use induced pluripotent stem (iPS) cells from patients with HD to screen for drugs that might delay, prevent, or even reverse this devastating condition.

16 Jun 2010

ADDF, AFTD announce recipients of Frontotemporal Dementia Drug Discovery Program award

The Alzheimer's Drug Discovery Foundation (ADDF) and the Association for Frontotemporal Dementias (AFTD) announced today the recipients of their third annual research award, Frontotemporal Dementia Drug Discovery Program. The goal of the program is to accelerate the development of novel therapies for frontotemporal dementia (FTD). The program will provide a total of $1,200,000 in research grants over four years.

8 Apr 2010

Mutant ATPase blocks autophagy partway and causes multi-tissue degenerative disease

It's important to finish what you start, say Jeong-Sun Ju and researchers from Washington University School of Medicine, St. Louis. In the December 14, 2009 issue of the Journal of Cell Biology (www.jcb.org), Ju et al. reveal how a mutant ATPase blocks autophagy partway through to cause a multi-tissue degenerative disease.

15 Dec 2009

Frontotemporal Dementia News and Research

Suberoylanilide hydroxamic acid holds promise against familial frontotemporal dementia

Many patients receive an incorrect dementia diagnosis: Lund study

Proteostasis acquires Harvard University's two novel protein target licenses

Sarcasm and lie detection failure signals dementia: Study

Person's inability to understand sarcasm and lies can be a warning sign of dementia

Malarial drugs may help treat specific form of frontotemporal dementia

Common psychiatric drugs could slow dementia

Career choice may influence where dementia takes root in the brain: Study

New research studies presented at Alzheimer's Association International Conference

Scientist leads global discussion, research on insula

ISB, GIND collaborate on whole-genome sequencing to identify drug targets for Huntington's Disease

ADDF, AFTD announce recipients of Frontotemporal Dementia Drug Discovery Program award

Mutant ATPase blocks autophagy partway and causes multi-tissue degenerative disease

Brain disorder that causes early dementia is highly hereditary: Study

New mouse models resembles human ALS; may provide important tool for screening new drugs

Mouse model of ALS closely resembles humans with the paralyzing disorder, says report

Positron emission tomography scans may improve the accuracy of dementia diagnosis

Neurodegeneration study reveals targets of destruction

Blood test predicts chance of frontal lobe dementia

Discovery of mechanism that may explain Parkinson's and other neurological disorders

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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