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New finding has potentially major implications for anti-angiogenic therapy

Scientists supported by the National Institute of Dental and Craniofacial Research (NIDCR) have added a key new piece to the puzzle of how tumor cells induce new blood vessels to form and fuel their abnormal growth, a well-known process called angiogenesis.

18 Jul 2005

Compound derived from cottonseed could help improve the effectiveness of chemotherapy at treating head and neck cancer

The findings, which appear in the July issue of the journal Molecular Cancer Therapeutics, could lead to a treatment that provides an effective option to surgically removing the cancer, helping patients preserve vital organs involved in speech and swallowing.

18 Jul 2005

Variations in the gene for protein kinase C beta 1 (PRKCB1) strongly associated with autism

This exciting finding suggests some answers to a number of previous, but unexplained, observations about autism and provides the potential for a mechanistic explanation for some of the characteristics of the condition. The results of the study are published today in the journal Molecular Psychiatry.

18 Jul 2005

Asthma may be linked to a decreased risk of brain cancer

According to new research there is a suggestion that gene variants known to raise the risk of asthma, might also decrease the risk of a common type of brain cancer that progresses rapidly and is fatal.

18 Jul 2005

New theory on aging says popping pills and drinking orange juice no guarantee you'll live longer

In direct contrast to previous reports, researchers now say that drinking gallons of orange juice and popping vitamin pills may not be a guarantee that you will live longer.

18 Jul 2005

Genome studies may help target new drugs to fight them

One parasite causes a deadly sleeping sickness in Africa. The second damages the internal organs of millions of Latin Americans. The third causes terrible lesions on the face or limbs of victims from Brazil to India.

18 Jul 2005

Study shows mutation in NOTCH1 gene causes aortic valve disease

By studying five generations of a Dallas family, UT Southwestern Medical Center researchers have discovered that a mutation in a key gene causes aortic valve disease, a common heart birth defect as well as a major contributor to adult heart disease.

18 Jul 2005

New molecular insights may one day lead to opportunities to stave off old age

Delving deep into the molecular subtleties of a strain of mice engineered to age rapidly, scientists have found that an accumulation of genetic mutations prompts a cascade of programmed cell death that seems to underpin the aging process.

18 Jul 2005

NIPA levels act as switch regulating cell division

Cells control mitosis (cell division) by assembling a biochemical switch to block it or by disassembling the switch to trigger it, according to investigators at St. Jude Children's Research Hospital and the Technical University of Munich.

18 Jul 2005

Scientists sequence the genomes of three species of parasites responsible for causing diseases that kill or cripple millions

Howard Hughes Medical Institute (HHMI) scientists who participated in the project say the sequencing of the genomes of the parasitic protozoa that cause Chagas disease, African sleeping sickness, and leishmaniasis, could significantly impact world health. Some of the genes discovered may prove to be good drug and vaccine targets.

17 Jul 2005

Lipid helps cell wall protein fold into proper shape

A protein that provides a vital passage through a bacterium's outer cell wall will misfold and malfunction if that wall is built of the 'wrong' material, scientists at The University of Texas Medical School at Houston report in a finding that has long-term implications for understanding diseases caused by misfolded proteins such as cystic fibrosis, Alzheimer's disease, and mad cow disease.

17 Jul 2005

Scientists have begun to clarify how one of the body's molecules controls the trafficking of T cells through the blood

...lymph nodes and on to tissues to fight infection -- a crucial response that sometimes goes awry, attacking the body's own tissues and causing autoimmune diseases.

17 Jul 2005

New compound ruboxistaurin may decrease vision loss in diabete

A multicenter international study chaired by a Joslin Diabetes Center investigator and reported in the July issue of the American Diabetes Association's journal Diabetes brings hopeful news to the 18 million people in the United States -- and millions more worldwide -- with type 1 or type 2 diabetes.

15 Jul 2005

Novel way in which the brain size of developing mammals may be regulated

Howard Hughes Medical Institute researchers have discovered a novel way in which the brain size of developing mammals may be regulated. They have identified a signaling pathway that controls the orientation in which dividing neural progenitor cells are cleaved during development.

14 Jul 2005

Complicated plasminogen system yields potential therapeutic target; Implications for aging and degenerative diseases

Skeletal muscles naturally repair themselves very efficiently after injury. But when they don’t, otherwise successful recovery following damage from overuse during exercise, surgery or trauma can be stymied. Furthermore, as we age, muscle repair slows noticeably, and in Duchenne Muscular Dystrophy and other degenerative muscle diseases, normal repair functions can’t cope with disease progression.

14 Jul 2005

Erlotinib increases survival in patients with advanced non-small cell lung cancer

An international clinical study led by Canadian researchers has demonstrated that a drug called erlotinib increases survival in patients with advanced non-small cell lung cancer who typically have no other treatment options.

13 Jul 2005

Transplanted neural stem cells may serve not only as replacement cells for tissue repair, but in some circumstances may also protect the brain from inflammation

Researchers at the San Raffaele Hospital (Milan, Italy) published unexpected results of studies in which immature nerve cells (adult mouse neural stem cells) injected into the blood of mice with MS-like disease were able to suppress the immune attacks that damage the brain and spinal cord tissues.

13 Jul 2005

Researchers gain better understanding of how nerves need to be reconnected after spinal cord injury

Nerve cells relay messages at blink-of-the-eye speeds by squirting chemicals called neurotransmitters across tiny gaps called synapses to awaiting message receptors. But lots of different receptors and neurotransmitters work simultaneously. Which goes where to send the proper message?

13 Jul 2005

White blood cell called a neutrophil appears to be crucial to abdominal aortic aneurysm formation

Each year, 200,000 Americans find out that the largest blood vessel in their body, the aorta, may burst open at any time. About 20,000 die suddenly from such a rupture. And another 36,000 have surgery to repair or replace the swelling section of aorta before time runs out.

13 Jul 2005

Stressgen granted U.S. patent providing coverage for the manufacture of HspE7

Stressgen Biotechnologies announced today that the U.S. Patent and Trademark Office granted US Patent Number 6,900,035, covering methods of manufacturing HspE7, the Company's lead product candidate for human papillomavirus (HPV)- related diseases and cancer.

13 Jul 2005

G Protein News and Research

New finding has potentially major implications for anti-angiogenic therapy

Compound derived from cottonseed could help improve the effectiveness of chemotherapy at treating head and neck cancer

Variations in the gene for protein kinase C beta 1 (PRKCB1) strongly associated with autism

Asthma may be linked to a decreased risk of brain cancer

New theory on aging says popping pills and drinking orange juice no guarantee you'll live longer

Genome studies may help target new drugs to fight them

Study shows mutation in NOTCH1 gene causes aortic valve disease

New molecular insights may one day lead to opportunities to stave off old age

NIPA levels act as switch regulating cell division

Scientists sequence the genomes of three species of parasites responsible for causing diseases that kill or cripple millions

Lipid helps cell wall protein fold into proper shape

Scientists have begun to clarify how one of the body's molecules controls the trafficking of T cells through the blood

New compound ruboxistaurin may decrease vision loss in diabete

Novel way in which the brain size of developing mammals may be regulated

Complicated plasminogen system yields potential therapeutic target; Implications for aging and degenerative diseases

Erlotinib increases survival in patients with advanced non-small cell lung cancer

Transplanted neural stem cells may serve not only as replacement cells for tissue repair, but in some circumstances may also protect the brain from inflammation

Researchers gain better understanding of how nerves need to be reconnected after spinal cord injury

White blood cell called a neutrophil appears to be crucial to abdominal aortic aneurysm formation

Stressgen granted U.S. patent providing coverage for the manufacture of HspE7

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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