Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Novel molecular targeting technologies to deliver gene-silencing therapy

Researchers have combined novel molecular targeting technologies to deliver gene-silencing therapy specifically to tumor cells shielded by a normally impermeable obstacle, the blood brain barrier.

1 Jun 2004

Randomness in gene expression to lead to differences in people that are genetically identical

Experiments by Howard Hughes Medical Institute (HHMI) researchers have revealed it might be possible for randomness in gene expression to lead to differences in cells — or people, for that matter — that are genetically identical.

27 May 2004

Men with low prostate specific antigen levels on screening tests can still have prostate cancer

Men with low PSA (prostate specific antigen) levels on screening tests can still have prostate cancer, according to a study* released today by scientists from the National Cancer Institute (NCI).

27 May 2004

Using gene therapy to fight rheumatoid arthritis

Guided by a similar principle, arthritis researchers at the University of Florida and Harvard University hope to use gene therapy to help joint cells pump out a harmless protein that parks in receptor sites, leaving a notorious inflammatory agent “circling the lot” and unable to cause pain, swelling and possible joint damage.

21 May 2004

Protein that appears to play a key role in Alzheimer's disease

A protein that allows human cancer to resist multiple anticancer drugs also appears to play a key role in Alzheimer's disease, according to research conducted at Fox Chase Cancer Center. The protein, active in brain tissue, could be a target for new drugs to treat patients with Alzheimer's.

20 May 2004

New study of tumor genetics may help to treat patients with head and neck cancer

Head and neck tumors account for more than 40,000 new cancers annually in the United States. The most common of these is squamous cell carcinoma. Prognosis is based largely on location and size of the tumor, and if the cancer has spread, or metastasized, to lymph nodes and distant sites in the body.

19 May 2004

Technique to visualize changes in nerve connections when flies learn may help to understand how memories form

For the first time, researchers have used a technique called optical imaging to visualize changes in nerve connections when flies learn. These changes may be the beginning of a complex chain of events that leads to formation of lasting memories.

14 May 2004

Launch of myDNA.com breast cancer channel

The myDNA.com Breast Cancer Channel integrates multi-cultural, relevant health information related to medications, clinical trials, support groups, leading hospitals, clinics, healthcare providers, and genetic, genomic and gene expression tests.

6 May 2004

New Canadian Fat Lab

As obesity is fast overtaking tobacco as the leading risk factor for heart disease, a new laboratory for studying the biology of fat cells (adipocytes) is opening its doors at the Henderson Research Centre.

5 May 2004

New technique to deliver gene therapy to soft-tissue tumors

Using new research and technology that shows bone marrow-derived mesenchymal stem cells (MSCs) will engraft at the site of a tumor and contribute to the growth of stromal fibroblasts (the healthy tissue surrounding a tumor)

2 May 2004

Researchers profile over 6000 genes in the two primary types of normal breast cells

For several years, scientists have attempted to identify gene expression changes, using microarrays or ‘DNA chips’, in order to understand and predict breast cancer onset, progression, and clinical outcome.

1 May 2004

A new prognostic marker has shown potential to predict recurrence in certain colon cancer patients

In the study, a team of researchers led by Veridex, LLC, a Johnson & Johnson company, used gene expression profiling to identify the new marker – a 23-gene signature – which may predict disease recurrence in patients initially diagnosed with Dukes' B colon cancer.

29 Apr 2004

Scientists have unraveled the behavior of one key component of bacteria

The researchers studied a mechanism of action they call the "magic spot" – an important regulator of gene expression. They describe their results in the current issue of the journal Cell.

29 Apr 2004

Scientists identify six genes associated with the most common form of non-Hodgkin's lymphoma

In a paper that will be published on Thursday, April 29, 2004 in the New England Journal of Medicine, a team of scientists from Stanford University and Applied Biosystems, an Applera Corporation business, describe the identification of six genes associated with survival in diffuse large B cell lymphoma (DLBCL), the most common form of non-Hodgkin's lymphoma.

28 Apr 2004

New analytical approach that combines genetic and clinical data to give individualized prognosis of cancer recurrence

Researchers at Duke University have developed a new analytical approach that combines genetic and clinical data to give cancer patients an individualized prognosis of their cancer recurrence. The information could prove critical in deciding how aggressively to treat the disease following surgery.

26 Apr 2004

Japanese scientists have created a viable mouse derived from two genetic mothers with no contribution by a male animal

Japanese scientists have created a viable mouse derived from two genetic mothers with no contribution by a male animal.

23 Apr 2004

Free software helps capture the molecular signatures of cells

A new, free software package developed by the Broad Institute of MIT and Harvard makes it easier and faster for scientists to capture the molecular signatures of cells in a particular state--information that's crucial to disease diagnosis and prognosis.

14 Apr 2004

Molecular analyses of leukemia patients suggest strategies for better treatments

The cure rate for pediatric acute lymphoblastic leukemia (ALL) might continue to rise with improved use of conventional therapies. But even more effective and less toxic therapies based on genetic and pharmacogenetic studies might one day push the success rate close to 100 percent, according to an article published by investigators at St. Jude Children’s Research Hospital in the April 8 issue of the New England Journal of Medicine.

7 Apr 2004

New research findings in study of Rett Syndrome

Rudolf Jaenisch of the Whitehead Institute of Biomedical Research in Cambridge, MA reports in the April 6, 2004 online issue of the Proceedings of the National Academy of Sciences that introduction of the MeCP2 protein into post-mitotic nerve cells of MeCP2 mutant mice rescues the symptoms of Rett Syndrome. This raises the possibility that neurons are functionally normal in a newborn child and that neural dysfunction manifests itself only later due to prolonged MeCP2 deficiency. If correct, therapeutic strategies aimed at preventing the onset of Rett symptoms could be initiated at birth.

7 Apr 2004

Zebrafish show effects of ionizing and UV radiation differ during embryo development

Adam Dicker, M.D., Ph.D., associate professor of radiation oncology at Jefferson Medical College of Thomas Jefferson University and Jefferson’s Kimmel Cancer Center in Philadelphia, Mary Frances McAleer, M.D., Ph.D., a resident in the Department of Radiation Oncology at Jefferson Medical College and their co-workers compared the effects on zebrafish embryos of two types of radiation – ionizing radiation, which is the kind given to patients for cancer treatment, and ultraviolet (UV) radiation, which comes naturally from the sun.

30 Mar 2004

Gene Expression News and Research

Further Reading

Novel molecular targeting technologies to deliver gene-silencing therapy

Randomness in gene expression to lead to differences in people that are genetically identical

Men with low prostate specific antigen levels on screening tests can still have prostate cancer

Using gene therapy to fight rheumatoid arthritis

Protein that appears to play a key role in Alzheimer's disease

New study of tumor genetics may help to treat patients with head and neck cancer

Technique to visualize changes in nerve connections when flies learn may help to understand how memories form

Launch of myDNA.com breast cancer channel

New Canadian Fat Lab

New technique to deliver gene therapy to soft-tissue tumors

Researchers profile over 6000 genes in the two primary types of normal breast cells

A new prognostic marker has shown potential to predict recurrence in certain colon cancer patients

Scientists have unraveled the behavior of one key component of bacteria

Scientists identify six genes associated with the most common form of non-Hodgkin's lymphoma

New analytical approach that combines genetic and clinical data to give individualized prognosis of cancer recurrence

Japanese scientists have created a viable mouse derived from two genetic mothers with no contribution by a male animal

Free software helps capture the molecular signatures of cells

Molecular analyses of leukemia patients suggest strategies for better treatments

New research findings in study of Rett Syndrome

Zebrafish show effects of ionizing and UV radiation differ during embryo development

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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