Gene Knockout News and Research

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Scientists identify the main components driving amyloid beta-associated synapse degeneration

Healthy adult brains are endowed with a vast number of synapses, structures that relay signals across nerve cells to enable communications, information processing and storage throughout the nervous system.

18 Aug 2021

Study identifies Foxo1 gene as a potential treatment target for hereditary lymphedema

A University of South Florida preclinical study unexpectedly identified the gene Foxo1 as a potential treatment target for hereditary lymphedema.

10 Aug 2021

Researchers study the role of subnuclear NSrp70 in T cell-mediated adaptive immunity

T cells are components of the body’s immune system. The ability of T cells to recognize diverse pathogens and mount a defense against them stems from the way proteins are spliced during their development and maturation.

15 Jul 2021

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

A new study by researchers at the University of Connecticut Health Center, USA, reports the crucial nature of the pathogen pattern recognition receptor (PRRs), especially the two RLRs, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), in triggering host cell immune responses within the cell. The RLRs are viral RNA sensors.

15 Feb 2021

Novel computational tool can systematically analyze cell images in C. elegans

A joint research team co-led by City University of Hong Kong (CityU) has developed a novel computational tool that can reconstruct and visualise three-dimensional (3D) shapes and temporal changes of cells, speeding up the analysing process from hundreds of hours by hand to a few hours by the computer.

23 Dec 2020

Scientists identify new therapeutic targets for SARS-CoV-2

To identify new potential therapeutic targets for SARS-CoV-2, a team of scientists at the New York Genome Center, New York University, and the Icahn School of Medicine at Mount Sinai, performed a genome-scale, loss-of-function CRISPR screen to systematically knockout all genes in the human genome.

27 Oct 2020

Nanomedicine-based strategy enhances anti-PD1 therapy to eradicate PTEN-negative GBM

A nanomedicine-based strategy for chemo-immunotherapy (CIT) of glioblastoma (GBM), which has the worst prognosis among brain tumors, was successfully developed.

7 Aug 2020

Identification of MTK1 SAPKKK as new human oxidative stress sensor

In an aging society, various studies are being conducted to explore the relationship between active oxygen and aging-related diseases such as cancer, chronic inflammatory diseases, and metabolic syndrome.

28 Jul 2020

Horizon Discovery introduces Cas9 and dCas9-VPR stable cell lines to simplify and accelerate CRISPR gene editing workflows

Horizon Discovery Group plc, today announced the introduction of its stably expressing Cas9 and dCas9-VPR cell lines to help accelerate gene knockout.

8 Jul 2020

New drug combinations could help overcome genetic immunotherapy resistance

A new study from researchers at the UCLA Jonsson Comprehensive Cancer Center helps explain how disruptions in genes can lead to the resistance to one of the leading immunotherapies, PD-1 blockade, and how new drug combinations could help overcome resistance to the anti-PD-1 therapy in a mechanistically-based way.

28 May 2020

GABA is a key regulator to metamorphosis, shows study

Metamorphosis, or a dramatic change in physical appearance, is a normal part of the life cycle of many animals, carried out to take advantage of different ecological niches.

1 Apr 2020

Scientists 'knock out' gene in myeloid cells to create listeriosis-immune mice

An international research team which includes specialists from ITMO University has conducted a series of experiments with the goal of studying the immune system and identifying the genes and proteins involved in the response to certain harmful bacteria.

28 Jan 2020

Horizon Discovery to offer novel base editing technology for clinical research

Horizon Discovery today announced that it will provide access to a novel base editing technology licensed from Rutgers for exclusive use in therapeutic, diagnostic and services applications.

From Revvity 14 Jan 2020

Horizon Discovery adds predesigned synthetic single guide RNA to its product range

Horizon Discovery Group plc, a global leader in the application of gene editing and gene modulation technologies, today announced the addition of predesigned synthetic single guide RNA (sgRNA) to its product range.

From Revvity 13 Dec 2019

Human apolipoprotein E promotes hepatitis B virus infection

Human apolipoprotein E (apoE) promotes hepatitis B virus (HBV) infection and production, according to a study published DATE in the open-access journal PLOS Pathogens by Luhua Qiao and Guangxiang (George) Luo of the University of Alabama at Birmingham School of Medicine.

From PLOS ONE 13 Aug 2019

Study identifies dozens of genetic mutations linked to albinism in ‘knockout’ mice

Albinism is the best-known of a group of rare genetic disorders that can affect both eyes and skin. Some genes have been identified that are linked to these conditions, but many remain mysterious.

2 Aug 2019

Study offers new clues to autism's underlying biology

Over the past decade, autism spectrum disorder has been linked to mutations in a variety of genes, explaining up to 30 percent of all cases to date.

21 Jun 2019

Finnish researchers discover gene mutation that reduces fear, anxiety and increases social interaction

Finnish researchers at the University of Eastern Finland and the University of Oulu have discovered of a new type of gene mutation that reduces fear and anxiety, and increases social interaction.

3 May 2019

Study describes vulnerability shared by large subset of cancer cell lines

Cancer cells adapt to potentially fatal mutations and other molecular malfunctions by adjusting one or more other genes' activity, in the process becoming dependent on those genes for their survival and growth.

12 Apr 2019

Researchers study animal venoms to identify new medicines for treating diseases

Animal venoms are the subject of study at research center based at the Butantan Institute in São Paulo. But in this case, the idea is not to find antidotes, but rather to use the properties of the venoms themselves to identify molecular targets of diseases and, armed with that knowledge, develop new compounds that can be used as medicines.

15 Feb 2019