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Salk researchers receive BRAIN Initiative funding

Salk researchers receive BRAIN Initiative funding

Joseph Ecker, a Salk professor and Howard Hughes Medical Institute investigator, and Margarita Behrens, Salk staff scientist, have been named recipients in the 2014 round of grants from the National Institutes of Health (NIH) through the BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative for leading-edge work in neuroscience. [More]
Study shows healthy fat in olive oil may revive a failing heart

Study shows healthy fat in olive oil may revive a failing heart

Oleate, a common dietary fat found in olive oil, restored proper metabolism of fuel in heart cells in an animal model of heart failure. [More]
Virginia Tech professor wins Paul L. Busch Award for outstanding work in water quality research

Virginia Tech professor wins Paul L. Busch Award for outstanding work in water quality research

Amy Pruden, professor of civil and environmental engineering at Virginia Tech, is the 2014 recipient of the Paul L. Busch Award, including a $100,000 research grant. [More]
Pitt researchers awarded $11.8 million NIH grant to explore genetic roots of cleft lip, palate

Pitt researchers awarded $11.8 million NIH grant to explore genetic roots of cleft lip, palate

Researchers at the University of Pittsburgh School of Dental Medicine have been awarded a $11.8 million, five-year grant from the National Institute of Dental and Craniofacial Research, part of the National Institutes of Health, to continue their exploration of the genetic roots of cleft lip and cleft palate and to expand the effort to include populations in Colombia, Nigeria, the Philippines and Pennsylvania. [More]
Prenatal maternal stress exposure to Quebec ice storm predicts epigenetic profile of offspring

Prenatal maternal stress exposure to Quebec ice storm predicts epigenetic profile of offspring

The number of days an expectant mother was deprived of electricity during Quebec's Ice Storm (1998) predicts the epigenetic profile of her child, a new study finds. [More]
TSRI study points way to potential therapies for hereditary spastic paraplegia

TSRI study points way to potential therapies for hereditary spastic paraplegia

Scientists at The Scripps Research Institute have discovered that a gene mutation linked to hereditary spastic paraplegia, a disabling neurological disorder, interferes with the normal breakdown of triglyceride fat molecules in the brain. The TSRI researchers found large droplets of triglycerides within the neurons of mice modeling the disease. [More]
Study assesses effectiveness of UK-wide screening programme for Lynch Syndrome

Study assesses effectiveness of UK-wide screening programme for Lynch Syndrome

Screening families of patients with bowel cancer for a genetic condition would cut their risk of developing bowel, womb, and ovarian cancers, new research has found. [More]
Myriad Genetics' Tumor BRACAnalysis CDx identifies 44% more candidates for PARP therapy

Myriad Genetics' Tumor BRACAnalysis CDx identifies 44% more candidates for PARP therapy

Myriad Genetics, Inc. today announced that its Tumor BRACAnalysis CDx- companion diagnostic test significantly improved the detection of cancer-causing BRCA1/2 mutations by 44 percent in women with ovarian cancer. Data from this new study were presented at the 2014 European Society for Medical Oncology annual meeting in Madrid, Spain. [More]
Scientists discover mechanism that resists cancer drugs in estrogen-positive breast cancer

Scientists discover mechanism that resists cancer drugs in estrogen-positive breast cancer

Scientists have discovered a previously unknown mechanism by which estrogen prepares cells to divide, grow and, in the case of estrogen-positive breast cancers, resist cancer drugs. The researchers say the work reveals new targets for breast cancer therapy and will help doctors predict which patients need the most aggressive treatment. [More]
Researchers create new Cas9 animal model for in vivo genome editing experiments

Researchers create new Cas9 animal model for in vivo genome editing experiments

Researchers from the Broad Institute and Massachusetts Institute of Technology have created a new mouse model to simplify application of the CRISPR-Cas9 system for in vivo genome editing experiments. [More]
Lung-MAP, ALCHEMIST clinical trials offer innovative study designs for lung cancer patients

Lung-MAP, ALCHEMIST clinical trials offer innovative study designs for lung cancer patients

The recent launch of two clinical trials offer innovative study designs for patients with lung cancer. These clinical trials are the direct result of a National Cancer Institute sponsored workshop chaired by Drs. Fred R. Hirsch, Shakun Malik and Claudio Dansky- Ullman, that brought together the NCI Thoracic Malignancies Steering Committee, the US Food and Drug Administration, academicians, clinicians as well as industry and government stakeholders to discuss issues and challenges related to clinical trial design and biomarkers for lung cancer targeted-therapies. [More]
Study provides support for new understanding of the immune system

Study provides support for new understanding of the immune system

A study published in the journal Science provides support for a new-and still controversial-understanding of the immune system. The research was conducted by collaborators in the U.S. and Europe, including Robert Cramer, PhD, an assistant professor of microbiology and immunology at the Geisel School of Medicine and member of the Dartmouth Lung Biology Center, and Kelly Shepherdson, PhD, at the time a graduate student in Cramer's lab. [More]
Cedars-Sinai to participate in a consortium studying motor neuron disorders

Cedars-Sinai to participate in a consortium studying motor neuron disorders

Investigators at the Cedars-Sinai Board of Governors Regenerative Medicine Institute have received a grant from the National Institutes of Health to participate in a consortium taking the study of motor neuron disorders - such as Lou Gehrig's disease and spinal muscular atrophy - to a new, comprehensive perspective. [More]
Scientists discover new clues about drug used in treating blood cancer

Scientists discover new clues about drug used in treating blood cancer

Keck Medicine of USC scientists have discovered new clues about a drug instrumental in treating a certain blood cancer that may provide important targets for researchers searching for cures. [More]
Research findings provide clues for design of future HIV vaccine

Research findings provide clues for design of future HIV vaccine

Scientists at The Scripps Research Institute have described how a single family of antibodies that broadly neutralizes different strains of HIV has evolved remarkably diverse structures to attack a vulnerable site on the virus. [More]
BRD4 protein appears to play key role in keeping stem cells in immature "pluripotent" state

BRD4 protein appears to play key role in keeping stem cells in immature "pluripotent" state

A protein implicated in several cancers appears to play a pivotal role in keeping stem cells in an immature "pluripotent" state, according to a new study by NYU Langone Medical Center scientists. [More]
International researchers identify novel causes for severe childhood epilepsies

International researchers identify novel causes for severe childhood epilepsies

In the largest collaborative study so far, an international team of researchers, including scientists from VIB and Antwerp University identified novel causes for severe childhood epilepsies. [More]
Two genes that cause pediatric glaucoma increases risk of future stroke up to ten times

Two genes that cause pediatric glaucoma increases risk of future stroke up to ten times

Every year in Canada about 50,000 people suffer from a stroke, caused either by the interruption of blood flow or uncontrolled bleeding in the brain. While many environmental risk factors exist, including high blood pressure and smoking, stroke risk is also frequently inherited. Unfortunately, remarkably little is known regarding stroke's genetic basis. [More]
Triple-punch of antibodies prevents, wipes out hepatitis C infection in laboratory mice

Triple-punch of antibodies prevents, wipes out hepatitis C infection in laboratory mice

A triple-punch of antibodies both prevented hepatitis C infection and wiped out the disease after it had established itself in laboratory mice, according to a study led by Princeton University researchers. [More]
‘Missing’ schizophrenia heritability found

‘Missing’ schizophrenia heritability found

Researchers have matched up single nucleotide polymorphism sets with clinical syndromes to show that previously identified genetic variants can account for nearly all cases of schizophrenia. [More]