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Experimental drug may become key tool to target triple-negative breast cancer with immunotherapy

Experimental drug may become key tool to target triple-negative breast cancer with immunotherapy

Previous studies at the University of Colorado Cancer Center show that the experimental drug AMPI-109 potently kills triple-negative breast cancer cells. [More]
Novel drug delivery system may offer new hope for patients with rare fatal genetic disorder

Novel drug delivery system may offer new hope for patients with rare fatal genetic disorder

Researchers at Oregon State University and other institutions have discovered a type of drug delivery system that may offer new hope for patients with a rare, ultimately fatal genetic disorder - and make what might become a terrible choice a little easier. [More]
Deficiency in important enzyme leads to alcohol dependency

Deficiency in important enzyme leads to alcohol dependency

A research group under the leadership of Linköping University Professor Markus Heilig has identified an enzyme whose production is turned off in nerve cells of the frontal lobe when alcohol dependence develops. [More]
Penn scientists find striking similarities between human patients with LCA and dogs

Penn scientists find striking similarities between human patients with LCA and dogs

Ciliopathies are diseases that affect the cilia, sensory organelles that most mammalian cells possess and which play a critical role in many biological functions. [More]
Gentle combination of FDA-approved drugs could combat photoreceptor degeneration in mice

Gentle combination of FDA-approved drugs could combat photoreceptor degeneration in mice

In microseconds, every light ray that enters the eye triggers an explosion of coordinated cellular events. [More]
Studying mutant peptides may help detect weaknesses in tumor cells

Studying mutant peptides may help detect weaknesses in tumor cells

Researchers from MIPT, the Institute of Biomedical Chemistry, the Institute for Energy Problems of Chemical Physics, and the Research Institute of Physico-Chemical Medicine have presented an algorithm to detect mutant proteins based on mass spectrometry data and the results of exome sequencing. [More]
Nicotinic receptors could be new therapeutic target to prevent memory loss linked to Alzheimer's

Nicotinic receptors could be new therapeutic target to prevent memory loss linked to Alzheimer's

Several scientific studies have indicated that nicotine may be beneficial for memory function. [More]
Leading Chikungunya vaccine in clinical trial phase 2

Leading Chikungunya vaccine in clinical trial phase 2

With the first patient vaccinated, a Phase 2 clinical trial of a promising prophylactic vaccine candidate against Chikungunya fever has now commenced. The product is the most advanced Chikungunya vaccine candidate globally and is developed by the Austrian biotech company Themis Bioscience GmbH. [More]
Skin cells derived from autistic donors grow faster than those from control subjects

Skin cells derived from autistic donors grow faster than those from control subjects

Brain cells grow faster in children with some forms of autism due to distinct changes in core cell signaling patterns, according to research from the laboratory of Anthony Wynshaw-Boris, MD, PhD, chair of the department of genetics and genome sciences at Case Western Reserve University School of Medicine. [More]
Newly-developed epigenetic test can be used to identify tumors responsible for metastasis in cancer patient

Newly-developed epigenetic test can be used to identify tumors responsible for metastasis in cancer patient

In patients with cancer, initial diagnosis most often includes the detection of the primary or original tumor and the presence or absence of metastases, ie cells from the original tumor that have escaped from their original location and are growing into other tissues of the patient. [More]
Basic cell biology research into neurodegeneration may fuel understanding of neurodegenerative diseases

Basic cell biology research into neurodegeneration may fuel understanding of neurodegenerative diseases

Clinical trials and translational medicine have certainly given people hope and rapid pathways to cures for some of mankind's most troublesome diseases, but now is not the time to overlook the power of basic research, says UC Santa Barbara neuroscientist Kenneth S. Kosik. [More]
Penn State dermatologist clarifies common myths about psoriasis

Penn State dermatologist clarifies common myths about psoriasis

Psoriasis is a much-misunderstood disease, often kept under wraps by sufferers who want to hide their skin lesions. [More]
Scientists devise new route to synthesize insecticide in 15 steps

Scientists devise new route to synthesize insecticide in 15 steps

For chemists like Sarah Reisman, professor of chemistry at Caltech, synthesizing molecules is like designing your own jigsaw puzzle. You know what the solved puzzle looks like--the molecule--and your job is to figure out the best pieces to use to put it together. [More]
Researchers explore molecular mechanisms through which lead exposure may affect neural stem cells

Researchers explore molecular mechanisms through which lead exposure may affect neural stem cells

Researchers have identified a potential molecular mechanism through which lead, a pervasive environmental toxin, may harm neural stem cells and neurodevelopment in children. [More]
Naturally-occurring sugars in woman's breast milk may protect infants against life threatening bacteria

Naturally-occurring sugars in woman's breast milk may protect infants against life threatening bacteria

A type of sugar found naturally in some women's breast milk may protect newborn babies from infection with a potentially life threatening bacterium called Group B streptococcus, according to a new study from Imperial College London. [More]
Novel small-molecule Wnt inhibitor may provide new treatment option for colorectal cancer patients

Novel small-molecule Wnt inhibitor may provide new treatment option for colorectal cancer patients

A team including the National Cancer Center, the RIKEN Center for Life Science Technologies , and Carna Biosciences Inc., has jointly announced the development of a novel small-molecule Wnt inhibitor named NCB-0846. [More]
Study reveals how pluripotency differs among mice, monkeys, and humans

Study reveals how pluripotency differs among mice, monkeys, and humans

Not too shabby, humans. New research shows that certain primate stem cells have pluripotency superior to some types derived from mice. [More]
Gene fusions in esophageal adenocarcinomas offer new molecular insights into lethal cancer

Gene fusions in esophageal adenocarcinomas offer new molecular insights into lethal cancer

Despite years of research, cellular mechanisms contributing to cancers like esophageal adenocarcinoma have remained elusive. [More]
Research findings point to potential drug targets to improve angiogenesis in diabetes patients

Research findings point to potential drug targets to improve angiogenesis in diabetes patients

Diabetes heightens the risk of vascular damage to heart and limbs, and impairs the ability to repair damage with new growth of blood vessels, called angiogenesis. [More]
Breakthrough in cancer cell screening advances personalised treatment of childhood leukaemia

Breakthrough in cancer cell screening advances personalised treatment of childhood leukaemia

Researchers at Newcastle University have been able to accurately predict how children whose cancer returns after treatment for leukaemia are likely to respond to further treatment. [More]
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