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Vaccination against single strain could confer protection against diverse Zika virus infections

Vaccination against single strain could confer protection against diverse Zika virus infections

Vaccination against a single strain of Zika virus should be sufficient to protect against genetically diverse strains of the virus, according to a study conducted by investigators from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health; Washington University in St. Louis; and Emory University in Atlanta. [More]
Research shows clear link between heart and the brain of LQTS patients

Research shows clear link between heart and the brain of LQTS patients

Researchers at the University of Rochester Medical Center recently discovered a genetic link between Long QT Syndrome (LQTS), a rare cardiac rhythm disease, and an increased risk for seizures. [More]
Researchers using internet to find study participants may hamper recruitment of minority, poor people

Researchers using internet to find study participants may hamper recruitment of minority, poor people

Recruiting minorities and poor people to participate in medical research always has been challenging, and that may not change as researchers turn to the internet to find study participants and engage with them online, new research suggests. [More]
Study clarifies role of KLF12 in CRC tumor growth

Study clarifies role of KLF12 in CRC tumor growth

Results of preclinical studies by MUSC investigators reported in the July 2016 issue of PLOS One, demonstrate for the first time that the transcription factor KLF12 promotes CRC cell growth, in part, by activating EGR1. Furthermore, data demonstrate that KLF12 and EGR1 levels synergistically correlate with poor CRC prognoses. [More]
Triple-combination therapy patch shrinks tumors, prevents recurrence in colon cancer mice model

Triple-combination therapy patch shrinks tumors, prevents recurrence in colon cancer mice model

Investigators at Brigham and Women's Hospital have developed a hydrogel patch that can adhere to tumors in a preclinical model of colon cancer, delivering a local, combination treatment as the elastic gel breaks down over time. [More]
Study verifies human gene therapy in MPS I animal model

Study verifies human gene therapy in MPS I animal model

Researchers are closer to finding a better way to treat children with a rare metabolic disorder called MPS I. It is caused by a deficiency of the key enzyme IDUA needed to break down complex sugars in cells. [More]
Novel method sheds light on how disruption in LRRK2 gene causes inherited Parkinson's disease

Novel method sheds light on how disruption in LRRK2 gene causes inherited Parkinson's disease

Scientists have developed a new method of measuring the activity of disease-causing mutations in the LRRK2 gene, a major cause of inherited Parkinson's disease. [More]
Study identifies two proteins crucial for self-renewal of skin stem cells

Study identifies two proteins crucial for self-renewal of skin stem cells

Our skin renews, heals wounds, and regenerates the hair that covers it thanks to a small group of stem cells. These cells continually produce new ones, which appear on the skin surface after a few days. [More]
Novel conjugate therapy shows promise in destroying ALL cells with few side effects

Novel conjugate therapy shows promise in destroying ALL cells with few side effects

Researchers at UC Davis and Ionis Pharmaceuticals have developed a hybrid treatment that harnesses a monoclonal antibody to deliver antisense DNA to acute lymphoblastic leukemia (ALL) cells and that may lead to less toxic treatments for the disease. [More]
Scientists identify novel way to target lung cancer through KRAS gene

Scientists identify novel way to target lung cancer through KRAS gene

UT Southwestern Medical Center researchers have identified a new way to target lung cancer through the KRAS gene, one of the most commonly mutated genes in human cancer and one researchers have so far had difficulty targeting successfully. [More]
New study to examine genomics of anti-platelet therapy after coronary interventions

New study to examine genomics of anti-platelet therapy after coronary interventions

Which antiplatelet medication is best after a coronary stent? The Tailored Antiplatelet Therapy to Lessen Outcomes After Percutaneous Coronary Intervention (TAILOR-PCI) Study examines whether prescribing heart medication based on a patient's CYP2C19 genotype will help prevent heart attack, stroke, unstable angina, and cardiovascular death in patients who undergo percutaneous coronary intervention (PCI), commonly called angioplasty. [More]
Blood pressure hormone system important for cardiovascular health can promote obesity

Blood pressure hormone system important for cardiovascular health can promote obesity

New research by University of Iowa scientists helps explain how a hormone system often targeted to treat cardiovascular disease can also lower metabolism and promote obesity. [More]
Scientists identify new group of molecules that could slow tumour growth in prostate cancer patients

Scientists identify new group of molecules that could slow tumour growth in prostate cancer patients

Prostate cancer patients have been offered hope after scientists at Newcastle University, UK, have identified a new group of molecules that could be targeted to slow tumour growth. [More]
Human immune system proteins can help combat chlamydia infections

Human immune system proteins can help combat chlamydia infections

Scientists from Federal Research and Clinical Centre of Physical-Chemical Medicine, Koltzov Institute of Developmental Biology and MIPT have shown that peptidoglycan recognition proteins (PGLYRPs) of the human immune system can play a key role in the fight against chlamydia infections. Their study was published in Infection and Immunity. [More]
New gene therapy shows promising results for treating neurodegenerative disorders

New gene therapy shows promising results for treating neurodegenerative disorders

A new gene therapy approach designed to replace the enzyme that is deficient in patients with the inherited neurodegenerative disorders Tay-Sachs and Sandhoff diseases successfully delivered the therapeutic gene to the brains of treated mice, restored enzyme function, and extended survival by about 2.5-fold. [More]
Researchers discover genetic changes in MSH3 gene in patients with hereditary colon cancer

Researchers discover genetic changes in MSH3 gene in patients with hereditary colon cancer

The formation of large numbers of polyps in the colon has a high probability of developing into colon cancer, if left untreated. [More]
Scientists identify mutation responsible for new, rare genetic disorder

Scientists identify mutation responsible for new, rare genetic disorder

An international team of researchers has discovered the mutation responsible for a rare, newly identified genetic disorder that causes craniofacial abnormalities and developmental delays. [More]
Study finds risk markers for Parkinson's disease hiding in unusual spots

Study finds risk markers for Parkinson's disease hiding in unusual spots

Clues that point toward new risk mechanisms for developing Parkinson's disease are hiding in some unusual spots, according to a study published today in Scientific Reports [More]
New consensus statement recommends transition of care for adolescents with neurologic disorders

New consensus statement recommends transition of care for adolescents with neurologic disorders

A new consensus statement provides recommendations for transitioning adolescents and young adults with neurologic disorders to adult care. [More]
Revolutionary surgery improves airway and jaw position in children with Treacher Collins syndrome

Revolutionary surgery improves airway and jaw position in children with Treacher Collins syndrome

A revolutionary surgery developed by Dr. Richard Hopper, surgical director of Seattle Children's Craniofacial Center, called subcranial rotation distraction, is changing the lives of children who are tracheostomy dependent. [More]
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