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Researchers identify multiple new subtypes of most common childhood cancer

Like cartographers completing a map, investigators have identified multiple new subtypes of the most common childhood cancer--research that will likely improve the diagnosis and treatment of high-risk patients.

14 Jan 2019

Molecular hallmarks of tumor hypoxia across 19 cancer types discovered

Unlike healthy tissues, tumors thrive in low-oxygen environments, often acquiring the ability to resist treatment and spread to other sites in the body. Despite being a well-known cause of therapy resistance and metastasis, the impact of low oxygen, known as hypoxia, on tumor cells is poorly understood.

14 Jan 2019

Scientists discover mutational signatures of tumor hypoxia

Researchers have discovered mutational signatures of tumor hypoxia in 19 cancer types that could be used to identify patients who need higher treatment doses.

14 Jan 2019

New path for treating Latino immigrants with mental health and substance misuse symptoms

A team of researchers at the Disparities Research Unit at Massachusetts General Hospital (MGH) - in collaboration with two teams in Spain and collaborators in the U.S. and Puerto Rico - has tested a novel preventive intervention designed to provide tailored treatment for Latino immigrants with both mental health and substance misuse symptoms.

11 Jan 2019

Study finds specific function of HIV protein that slows viral spread in early stages of infection

A study from a Massachusetts General Hospital research team has identified the specific function of a protein found in HIV and related viruses that appears to slow down viral spread in the earliest stages of infection.

11 Jan 2019

Bacteria on the International Space Station are adapting to survive, not to harm

Mutant bacteria stranded in space by visiting astronauts have been adapting to survive in their new environment, according to a new study.

10 Jan 2019

HIMSS recognizes Rush for reaching Stage 7 on Adoption Model for Analytics Maturity

Rush University Medical Center is just the third health care provider in the country to achieve the Healthcare Information and Management Systems Society's Stage 7 for the Adoption Model for Analytics Maturity.

10 Jan 2019

NorthShore and Color partner to deliver the power of genomics in routine primary care

NorthShore University HealthSystem and Color today announced a groundbreaking partnership to deliver the power of genomics to routine primary care at population scale.

9 Jan 2019

New mechanism of gene regulation involved in tumor progression discovered

Genes contain all the information needed for the functioning of cells, tissues, and organs in our body. Gene expression, meaning when and how are the genes being read and executed, is thoroughly regulated like an assembly line with several things happening one after another.

9 Jan 2019

Study shows how specific mutations in SYNE1 gene may increase bipolar disorder risk

A new study by researchers at The Picower Institute for Learning and Memory at MIT finds that the protein CPG2 is significantly less abundant in the brains of people with bipolar disorder and shows how specific mutations in the SYNE1 gene that encodes the protein undermine its expression and its function in neurons.

9 Jan 2019

New ACMG points to consider: Patient re-contact after revision of genomic test results

Genomic testing is becoming increasingly common in medicine. Moreover, ongoing advances in technology and an ever-increasing understanding of what genetic variants mean can result in reinterpretation of the clinical significance of variants found in patients.

9 Jan 2019

Novel technique detects new strains of microbes in human fecal microbiota after obesity surgery

Using a unique bioinformatics technique developed at the University of Alabama at Birmingham, UAB researchers have detected the emergence of new strains of microbes in the human fecal microbiota after obesity surgery.

9 Jan 2019

Scientists explore bacterial immunity to better understand infectious disease

Patients with cystic fibrosis are often infected by pseudomonas aeruginosa, a bacterium that infects the lungs and prevents breathing, often causing death.

8 Jan 2019

New molecular engineering method improves precision of biomarker analysis

Researchers from the University of Helsinki in cooperation with the University of Tartu, Competence Centre on Health Technologies from Estonia, and the Karolinska Institute, published an article in Nature's partner journal Genomic Medicine in which they present Targeted Allele Counting by sequencing along with several of its potential applications.

8 Jan 2019

Researchers design new questionnaire to improve knowledge of impact of menopause on women

A new questionnaire being developed through a collaboration between the Massachusetts General Hospital Midlife Women's Health Center and the North American Menopause Society is designed to improve knowledge of the extent and impact on women of genitourinary symptoms of menopause.

8 Jan 2019

MGH-led research team reveals how solid stress impacts tissue surrounding brain tumors

A Massachusetts General Hospital-led research team has demonstrated, for the first time, how solid stress - the physical forces exerted by the solid components of a tumor - impacts the tissue surrounding brain tumors and contributes to resulting neurological dysfunction and neuronal cell death.

8 Jan 2019

Biomarkers identified that could predict the risk of stroke

Researchers have successfully developed two biomarkers that could help predict the risk of a heart condition and stroke.

7 Jan 2019

Genes are involved in development of atrial fibrillation

Atrial fibrillation is the most common form of heart arrhythmia. About ten per cent of everyone over age 75 develop this condition, in which the two upper chambers of the heart (the atria) beat much faster than the main chambers (the ventricles), creating a fluttering feeling in the chest.

7 Jan 2019

Scientists highlight lack of diversity in genomic studies

A growing number of genomic studies have generated important discoveries regarding human health and behavior, but new research from the University of Oxford suggests that scientific advancement is limited by a lack of diversity.

7 Jan 2019

GE Healthcare and VUMC announce partnership to enable safer, more precise cancer immunotherapies

GE Healthcare and Vanderbilt University Medical Center today announced a five-year partnership to enable safer and more precise cancer immunotherapies. Multiple diagnostic tools will be developed to help predict both the efficacy of an immunotherapy treatment and its adverse effects for a specific patient before the therapy is administered.

7 Jan 2019

Genomic News and Research

Researchers identify multiple new subtypes of most common childhood cancer

Molecular hallmarks of tumor hypoxia across 19 cancer types discovered

Scientists discover mutational signatures of tumor hypoxia

New path for treating Latino immigrants with mental health and substance misuse symptoms

Study finds specific function of HIV protein that slows viral spread in early stages of infection

Bacteria on the International Space Station are adapting to survive, not to harm

HIMSS recognizes Rush for reaching Stage 7 on Adoption Model for Analytics Maturity

NorthShore and Color partner to deliver the power of genomics in routine primary care

New mechanism of gene regulation involved in tumor progression discovered

Study shows how specific mutations in SYNE1 gene may increase bipolar disorder risk

New ACMG points to consider: Patient re-contact after revision of genomic test results

Novel technique detects new strains of microbes in human fecal microbiota after obesity surgery

Scientists explore bacterial immunity to better understand infectious disease

New molecular engineering method improves precision of biomarker analysis

Researchers design new questionnaire to improve knowledge of impact of menopause on women

MGH-led research team reveals how solid stress impacts tissue surrounding brain tumors

Biomarkers identified that could predict the risk of stroke

Genes are involved in development of atrial fibrillation

Scientists highlight lack of diversity in genomic studies

GE Healthcare and VUMC announce partnership to enable safer, more precise cancer immunotherapies

Genetics & Genomics - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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