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New drug shows promise in treating sarcomas

A new compound that targets a receptor within sarcoma cancer cells shrank tumors and hampered their ability to spread in mice and pigs, a study from researchers at the University of Illinois reports.

14 Dec 2018

Acne could have a genetic basis find researchers promising new cure

In one of the pioneering genetic studies of acne, it has been seen that the condition that affects millions of teenagers and adults could have a genetic basis. This genetic study can also pave the way for new and accurate treatment for acne promise researchers. The study results are published in the latest issue of the journal Nature Communications.

13 Dec 2018

New mouse model shows potential for rapid identification of promising muscular dystrophy therapies

A Massachusetts General Hospital research team has created a new mouse model of a common form of muscular dystrophy with the potential of rapidly distinguishing promising therapeutic drugs from those unlikely to be successful.

13 Dec 2018

Blood test helps identify distinct molecular signatures in children with cystic fibrosis

Researchers at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, and colleagues, used a blood test and microarray technology to identify distinct molecular signatures in children with cystic fibrosis.

12 Dec 2018

Genetics study offers hope for new acne treatment

A discovery by researchers from the School of Basic & Medical Biosciences and NIHR Guy's and St Thomas' Biomedical Research Centre could lead to new treatments for severe acne. Scientists found 15 genome regions linked to developing the condition.

12 Dec 2018

Faster, cheaper test has potential to enhance prostate cancer evaluation

For men newly diagnosed with prostate cancer or patients previously treated, the risk of metastasis is a crucial determinant of whether to choose conservative management or undergo further treatment.

12 Dec 2018

Ezogabine treatment reduces motor neuron excitability in ALS patients, study shows

Brian Wainger, MD, PhD, of the Healey Center for ALS at Massachusetts General Hospital presented initial, top-level results of a recently completed phase 2 clinical trial of ezogabine (also called retigabine) on December 9 at the Motor Neurone Disease Association annual meeting in Glasgow, Scotland.

11 Dec 2018

New data from TAILORx trial confirms lack of chemo benefit regardless of race or ethnicity

An analysis of race and ethnicity data from the TAILORx clinical trial was presented at the 2018 San Antonio Breast Cancer Symposium.

10 Dec 2018

Black women with breast cancer have worse outcomes despite receiving equivalent treatments as white women

Even with equivalent treatments in women with hormone receptor-positive, HER2-negative breast cancer, black women had significantly higher breast cancer recurrence and increased overall mortality compared to white women in a large phase III clinical trial, TAILORx, according to data presented at the 2018 San Antonio Breast Cancer Symposium, held Dec. 4-8.

7 Dec 2018

New technology for profiling genetic makeup of myeloma tumor cells developed

Cancer arises when cells lose control. Deciphering the "blueprint" of cancer cells - outlining how cancer cells hijack specific pathways for uncontrolled proliferation - will lead to more efficient ways to fight it.

7 Dec 2018

Elevated hormone flags liver disease in mice with serious genomic disorder

Researchers have discovered that a hormone, fibroblast growth factor 21 (FGF21), is extremely elevated in mice with liver disease that mimics the same condition in patients with methylmalonic acidemia (MMA), a serious genomic disorder.

6 Dec 2018

Study reveals how the absence of Dna2 enzyme affects chromosome instability

Cells have in place a number of mechanisms to protect the integrity of the genome, including processes that repair mistakes that may occur during DNA replication.

6 Dec 2018

New massive sequencing platform implemented for double factor preimplantation genetic testing

A research team from the Universitat Autònoma de Barcelona, in collaboration with the Blood and Tissue Bank of Catalonia, has managed to implement a massive sequencing platform for Preimplantation Genetic Testing for the first time in history.

5 Dec 2018

CEASE intervention enhances delivery of smoking cessation assistance for breastfeeding mothers

A study led by MassGeneral Hospital for Children researchers demonstrates that an MGHfC-developed program designed to help the parents of pediatric patients quit smoking can increase the provision of such assistance to breastfeeding mothers.

5 Dec 2018

FDA takes significant step forward in driving development of novel genetic tests

The U.S. Food and Drug Administration today took a significant step forward in driving the efficient development of novel diagnostic technologies that scan a person's DNA to diagnose genetic diseases and guide medical treatments.

5 Dec 2018

Sema4, Mount Sinai, Sanofi announce launch of new collaborative asthma study

Sema4, a patient-centered predictive health company, and the Mount Sinai Health System today announced the launch of a five-year collaborative study with Sanofi designed to provide new insights into the biological mechanisms and other factors implicated in asthma.

4 Dec 2018

Epigenetic maps of the inner ear could lead to development of therapeutics for hearing loss

Epigenetics is the expression and control of genes. The epigenetics involved in the inner ear is a critical part of the mystery of hearing.

3 Dec 2018

Researchers uncover genes that lead to excessive tau in dementia

Researchers have identified two major groups of genes involved in the mutations that lead to excess production of tau, a protein involved in dementia.

3 Dec 2018

Study uncovers how HIV DNA is blocked from entering the cell nucleus

Multiple components of the nuclear pore complex and nuclear import machinery enable a protein called human myxovirus resistance 2 (MX2) to inhibit HIV-1 infection, according to a study published November 29 in the open-access journal PLOS Pathogens by Michael Malim of King’s College London, and colleagues.

3 Dec 2018

Cleveland Clinic expert develops personalized prediction model for Myelodysplastic Syndromes

At the American Society of Hematology Annual Meeting, Cleveland Clinic medical hematologist and oncologist Aziz Nazha, M.D., will present results of a personalized prediction model that surpassed current prediction models for Myelodysplastic Syndromes.

3 Dec 2018

Genomic News and Research

New drug shows promise in treating sarcomas

Acne could have a genetic basis find researchers promising new cure

New mouse model shows potential for rapid identification of promising muscular dystrophy therapies

Blood test helps identify distinct molecular signatures in children with cystic fibrosis

Genetics study offers hope for new acne treatment

Faster, cheaper test has potential to enhance prostate cancer evaluation

Ezogabine treatment reduces motor neuron excitability in ALS patients, study shows

New data from TAILORx trial confirms lack of chemo benefit regardless of race or ethnicity

Black women with breast cancer have worse outcomes despite receiving equivalent treatments as white women

New technology for profiling genetic makeup of myeloma tumor cells developed

Elevated hormone flags liver disease in mice with serious genomic disorder

Study reveals how the absence of Dna2 enzyme affects chromosome instability

New massive sequencing platform implemented for double factor preimplantation genetic testing

CEASE intervention enhances delivery of smoking cessation assistance for breastfeeding mothers

FDA takes significant step forward in driving development of novel genetic tests

Sema4, Mount Sinai, Sanofi announce launch of new collaborative asthma study

Epigenetic maps of the inner ear could lead to development of therapeutics for hearing loss

Researchers uncover genes that lead to excessive tau in dementia

Study uncovers how HIV DNA is blocked from entering the cell nucleus

Cleveland Clinic expert develops personalized prediction model for Myelodysplastic Syndromes

Genetics & Genomics - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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