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Scientists identify novel way to target lung cancer through KRAS gene

Scientists identify novel way to target lung cancer through KRAS gene

UT Southwestern Medical Center researchers have identified a new way to target lung cancer through the KRAS gene, one of the most commonly mutated genes in human cancer and one researchers have so far had difficulty targeting successfully. [More]
Scientists develop prediction score to identify older adults at risk of developing pneumonia

Scientists develop prediction score to identify older adults at risk of developing pneumonia

In a study published in the Journal of American Geriatrics Society, researchers developed a "prediction score" to help healthcare professionals determine which older adults might be most at risk for developing pneumonia. [More]
Researchers examine link between poor physical performance and dementia risk in oldest adults

Researchers examine link between poor physical performance and dementia risk in oldest adults

The number of people living well into their 90s is projected to quadruple by 2050. By mid-century, nearly 9 million people will be 90-years-old or older. [More]
Scientists discover group of genes that can help predict damage in transplanted kidney

Scientists discover group of genes that can help predict damage in transplanted kidney

A multicenter team of researchers led by Barbara Murphy, MD, of the Icahn School of Medicine at Mount Sinai has identified a panel of genes which can help predict whether a transplanted kidney will later develop fibrosis, an injury which can cause the organ to fail. Their results were published in the July 21 edition of Lancet. [More]
HSS researchers launch new study to find if stem cell treatment could help people with knee arthritis

HSS researchers launch new study to find if stem cell treatment could help people with knee arthritis

Researchers at Hospital for Special Surgery have launched a study to determine if a treatment using stem cells could help people with painful knee arthritis. [More]
Patient characteristics, outcomes differ for indoor and outdoor fallers, study shows

Patient characteristics, outcomes differ for indoor and outdoor fallers, study shows

Falling can have serious consequences for older adults, including a loss of function and increased risk of institutionalization. [More]
Researchers discover novel neuroprotection strategies to slow progression of Parkinson's disease

Researchers discover novel neuroprotection strategies to slow progression of Parkinson's disease

Using a robust model for Parkinson's disease, University of Alabama at Birmingham researchers and colleagues have discovered an interaction in neurons that contributes to Parkinson's disease, and they have shown that drugs now under development may block the process. [More]
Buprenorphine implants could be effective option to treat adults with opioid dependence

Buprenorphine implants could be effective option to treat adults with opioid dependence

While buprenorphine has long been used to treat adults with opioid dependence, its efficacy can be hindered by lack of adherence to daily, sublingual (beneath the tongue) doses of the medication. [More]
New method helps characterize immune cells in tumor tissues

New method helps characterize immune cells in tumor tissues

Despite recent achievements in the development of cancer immunotherapies, only a small group of patients typically respond to them. Predictive markers of disease course and response to immunotherapy are urgently needed. [More]
JAD announces recipient of 2016 Alzheimer Award

JAD announces recipient of 2016 Alzheimer Award

The Journal of Alzheimer's Disease is pleased to announce that Mark W. Bondi, PhD, ABPP/CN, Professor of Psychiatry at UC San Diego and Director of the Neuropsychological Assessment Unit at the VA San Diego Healthcare System, has been chosen as the recipient of the 2016 Alzheimer Award presented by the journal in recognition of his outstanding work on the development of a novel and promising method of staging preclinical Alzheimer's disease (AD) based on number of abnormal biomarkers that is predictive of progression to mild cognitive impairment (MCI) and AD. [More]
Study shows parvalbumin-interneurons in the amygdala influence fear memory encoding

Study shows parvalbumin-interneurons in the amygdala influence fear memory encoding

Fear memory encoding, the process responsible for persistent reactions to trauma-associated cues, is influenced by a sparse but potent population of inhibitory cells called parvalbumin-interneurons (PV-INs) in the amygdala, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published online July 14 in the journal Neuron. [More]
UCLA-led study finds wide acceptance of end-of-life care orders among California nursing home residents

UCLA-led study finds wide acceptance of end-of-life care orders among California nursing home residents

UCLA-led research finds broad acceptance of written end-of-life care orders among California nursing home residents, with nearly half completing a Physician Orders for Life-Sustaining Treatment, or POLST, form in 2011. [More]
TBI with LOC linked to late-life neurodegeneration but not Alzheimer's disease

TBI with LOC linked to late-life neurodegeneration but not Alzheimer's disease

Traumatic brain injury (TBI) with a loss of consciousness (LOC) may be associated with later development of Parkinson's disease but not Alzheimer's disease or incident dementia, according to a study conducted at the Icahn School of Medicine at Mount Sinai and the University of Washington School of Medicine. [More]
Study finds delayed onset of illness for centenarians than younger counterparts

Study finds delayed onset of illness for centenarians than younger counterparts

Research has shown that the human lifespan has the potential to be extended. But would this merely mean people living longer in poor health? The upbeat findings from a new study in the Journal of the American Geriatrics Society indicate that those extra years could well be healthy ones [More]
Scientists develop new nonradioactive method to determine telomere length

Scientists develop new nonradioactive method to determine telomere length

UT Southwestern Medical Center cell biologists have identified a new method for determining the length of telomeres, the endcaps of chromosomes, which can influence cancer progression and aging. [More]
Communication training for orthopedic surgery residents seeks to enhance interactions with older adults

Communication training for orthopedic surgery residents seeks to enhance interactions with older adults

A program to improve orthopedic surgery residents' communication skills with older adults is having a positive impact, according to a new study. [More]
Researchers identify exact origin of 2009 swine H1N1 flu pandemic

Researchers identify exact origin of 2009 swine H1N1 flu pandemic

The 2009 swine H1N1 flu pandemic — responsible for more than 17,000 deaths worldwide — originated in pigs from a very small region in central Mexico, a research team headed by investigators at the Icahn School of Medicine at Mount Sinai is reporting. [More]
Virus-like elements within human genome linked to development of lupus and Sjogren's syndrome

Virus-like elements within human genome linked to development of lupus and Sjogren's syndrome

Researchers at Hospital for Special Surgery have uncovered a potential genetic trigger of systemic autoimmune disease. [More]

New study reveals how adapter older adults live well, despite having chronic illnesses

You might believe that older adults who deal with extensive chronic illnesses or serious diseases would be more likely to be frail and to have a poorer quality of life than healthier older adults. [More]
Study examines how frequently older adults with diagnosed and undiagnosed dementia perform unsafe activities

Study examines how frequently older adults with diagnosed and undiagnosed dementia perform unsafe activities

Dementia currently affects some 5 million people in the U.S., and that number is expected to triple by 2050. Having dementia affects the way you think, act, and make decisions. [More]
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