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Research provides pathway toward creation of first broad-spectrum antiviral drug

Research provides pathway toward creation of first broad-spectrum antiviral drug

By studying the rare person -- about one in a million -- who can fight off viral infections more effectively than everyone else, investigators at the Icahn School of Medicine at Mount Sinai have developed a strategy to help the rest of us achieve this enhanced anti-viral state. [More]
Older, frail hypertensive adults could benefit from intensive lowering of blood pressure

Older, frail hypertensive adults could benefit from intensive lowering of blood pressure

Adults with hypertension who are age 75 years and older, including those who are frail and with poor overall health, could benefit from lowering their blood pressure below current medical guidelines. [More]
More than 7 in 10 older hip fracture patients not aware of having osteoporosis

More than 7 in 10 older hip fracture patients not aware of having osteoporosis

More than 7 in 10 older adults who suffer hip fractures aren't told they have the bone-weakening disease osteoporosis - despite the fact that hip fractures nearly always signify the presence of this potentially debilitating condition, according to revealing new research by Northwell Health physicians. [More]
Serum biomarkers can help predict risk of IBD development and complications

Serum biomarkers can help predict risk of IBD development and complications

Years before inflammatory bowel disease (IBD) is diagnosed and symptoms exist, biomarkers are already circulating that can help predict risk not only of disease development but also of complications, according to research published online last week, which will also appear in the June 15th print issue of Alimentary Pharmacology & Therapeutics. [More]
Guide to advance directives: an interview with Dr Lisa Price

Guide to advance directives: an interview with Dr Lisa Price

An advance directive is a very specific legal document that details the medical treatments you want, and, importantly, don’t want, if you’re unable to communicate with a physician. This may happen as a result of a critical illness that could make you confused or unable to speak. [More]
Older women at increased risk of receiving inappropriate prescription medicines, study shows

Older women at increased risk of receiving inappropriate prescription medicines, study shows

Nearly one in three British Columbia women over age 65 received inappropriate prescription medicines in 2013, according to a University of British Columbia study. One in four men of the same age received similar prescriptions. [More]
Researchers examine critical role of hypoxia in induction, amplification of FOP lesions

Researchers examine critical role of hypoxia in induction, amplification of FOP lesions

The cellular response to the lack of oxygen fans the flames of flare-ups in a rare bone disorder. In fibrodysplasia ossificans progressiva (FOP), a mutation triggers bone growth in muscles, which limits motion, breathing, and swallowing, among a host of progressive symptoms. [More]
Novel gene therapy can treat pulmonary hypertension linked with heart failure

Novel gene therapy can treat pulmonary hypertension linked with heart failure

Scientists have used a novel gene therapy to halt the progression of pulmonary hypertension, a form of high blood pressure in the lung blood vessels that is linked to heart failure, according to a study led by Roger J. Hajjar, MD, Professor of Medicine and Director of the Cardiovascular Research Center at the Icahn School of Medicine at Mount Sinai. [More]
Older women with chronic health problems more likely to have lower quality of life

Older women with chronic health problems more likely to have lower quality of life

Researchers writing in the Journal of the American Geriatrics Society recently learned that older women who are frail, and who have six or more chronic health conditions, are twice as likely to have a lower quality of life compared to women with less than three risk factors. [More]
Frailty, depression symptoms in older adults can affect spouses

Frailty, depression symptoms in older adults can affect spouses

Frailty, a condition that affects 10 percent of people aged 65 and older, can make older adults more prone to disability, falls, hospitalization and a shorter lifespan. Recently, researchers writing in the Journal of the American Geriatrics Society examined the effects of frailty and depression on married couples. [More]
Under-expressed miR-9 gene may contribute to schizophrenia risk

Under-expressed miR-9 gene may contribute to schizophrenia risk

By turning skin cells into brain neurons, researchers at the Icahn School of Medicine at Mount Sinai have identified that certain tiny molecules aiding in gene expression, known as microRNAs (miRNAs), are under-expressed in the brains of the 14 schizophrenia patients they studied. Their findings, published online today in the journal Cell Reports, show that one of these molecules, a miRNA known as miR-9, is a risk factor that controls the activity of hundreds of genes. [More]
Bacteria-derived gut metabolites can affect brain’s myelin content and induce depression-like symptoms

Bacteria-derived gut metabolites can affect brain’s myelin content and induce depression-like symptoms

Specific combinations of gut bacteria produce substances that affect myelin content and cause social avoidance behaviors in mice, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published today in the medical journal eLife. This research suggests that targeting intestinal bacteria, or their metabolites, could be one way to treat debilitating psychiatric disorders and demyelinating diseases, like multiple sclerosis. [More]
New diagnostic approach may help physicians more efficiently screen for dementia

New diagnostic approach may help physicians more efficiently screen for dementia

A tiered diagnostic approach that incorporates clinical, imaging and laboratory data may help physicians more efficiently screen for neurodegenerative disorders such as dementia, according to the consensus of a multi-disciplinary panel of experts. [More]
Researchers evaluate TBI-associated risk factors in older adults

Researchers evaluate TBI-associated risk factors in older adults

Traumatic brain injury (TBI), a leading cause of death and disability, has become so common in recent times that it has been called a "silent epidemic." And because older adults are more likely to suffer TBI, have worse outcomes, and are less likely to survive their injury than younger adults, older adults are considered a "silent population" within this epidemic. [More]
Researchers examine effectiveness of antipsychotic drugs to prevent or treat delirium

Researchers examine effectiveness of antipsychotic drugs to prevent or treat delirium

In a study published in the Journal of the American Geriatrics Society, researchers examined whether or not antipsychotic drugs, which are sometimes used to prevent or treat delirium, are effective. [More]
Removal of Dnmt1 enzyme during OPC differentiation could lead to neurological symptoms

Removal of Dnmt1 enzyme during OPC differentiation could lead to neurological symptoms

The removal of the enzyme Dnmt1 during oligodendrocyte progenitor cell (OPC) differentiation in the central nervous system resulted in inefficient myelin formation and neurological deterioration, including loss of control of bodily movements, in mice, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published today in the medical journal Cell Reports. The results could lead to a new understanding of multiple sclerosis and other myelin disorders in humans. [More]
Lung ultrasound may be highly effective, safe for diagnosing pneumonia in children

Lung ultrasound may be highly effective, safe for diagnosing pneumonia in children

Lung ultrasound has been shown to be highly effective and safe for diagnosing pneumonia in children and a potential substitute for chest X-ray, according to a study conducted at the Icahn School of Medicine at Mount Sinai. Results are currently published in the medical journal Chest. [More]
Wake Forest Baptist researchers looking for ways to keep older adults on their feet

Wake Forest Baptist researchers looking for ways to keep older adults on their feet

There's no getting around it: Simply getting around is a major issue for older adults.
"People are in nursing homes for two reasons, either they can't think or they can't walk," said Stephen Kritchevsky, Ph.D., director of the Sticht Center on Aging at Wake Forest Baptist Medical Center. North Carolina. "We're working very hard on the thinking part, and the walking part is equally important. [More]
Two common approaches to post-operative AF equally safe, effective

Two common approaches to post-operative AF equally safe, effective

Cleveland Clinic researchers, as part of the Cardiothoracic Surgical Trials Network, have found that two common approaches to post-operative atrial fibrillation - rhythm control and rate control - are equally safe and effective. [More]
Mount Sinai Health System recognized as 'Leaders in LGBT Healthcare Equality' by HRC Foundation

Mount Sinai Health System recognized as 'Leaders in LGBT Healthcare Equality' by HRC Foundation

Six campuses of the Mount Sinai Health System - The Mount Sinai Hospital, Mount Sinai Beth Israel, Mount Sinai St. Luke's, Mount Sinai West (formerly known as Mount Sinai Roosevelt), Mount Sinai Queens, and New York Eye and Ear Infirmary of Mount Sinai - have been recognized as "Leaders in LGBT Healthcare Equality" by the Human Rights Campaign (HRC) Foundation, the educational arm of the country's largest lesbian, gay, bisexual and transgender (LGBT) civil rights organization. [More]
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