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Ghrelin is a hormone produced mainly by P/D1 cells lining the fundus of the human stomach and epsilon cells of the pancreas that stimulates appetite. Ghrelin levels increase before meals and decrease after meals. It is considered the counterpart of the hormone leptin, produced by adipose tissue, which induces satiation when present at higher levels. Ghrelin is also produced in the hypothalamic arcuate nucleus where it stimulates the secretion of growth hormone from the anterior pituitary gland.
Wen Dan Tang significantly reduces insomnia-related anxiety

Wen Dan Tang significantly reduces insomnia-related anxiety

Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medicine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. [More]
Georgia Regents Medical Center explores new treatment for Parkinson's disease-related constipation

Georgia Regents Medical Center explores new treatment for Parkinson's disease-related constipation

Georgia Regents Medical Center is among about a dozen centers nationally exploring the potential of a new drug that may offer relief to people with Parkinson's who have failed standard approaches to treating constipation. [More]

Aeterna Zentaris announces FDA acceptance for filing of macimorelin acetate NDA for AGHD

Aeterna Zentaris Inc. today announced that the U.S. Food and Drug Administration has accepted for filing the Company's New Drug Application for its ghrelin agonist, macimorelin acetate, in Adult Growth Hormone Deficiency. The acceptance for filing of the NDA indicates the FDA has determined that the application is sufficiently complete to permit a substantive review. [More]
Obesity is an expensive problem, says bariatric surgeon

Obesity is an expensive problem, says bariatric surgeon

As a preeminent expert in the field of obesity surgery, board-certified bariatric surgeon Michael Feiz, M.D., F.A.C.S, has personally seen the physical, emotional and financial toll that obesity takes on his patients. [More]
Embolizing left gastric artery may be potential bariatric treatment for weight loss

Embolizing left gastric artery may be potential bariatric treatment for weight loss

A new study reports that individuals who underwent embolization of the left gastric artery for gastrointestinal bleeding experienced a 7.9 percent decrease in body weight three months after the procedure. [More]
Transarterial embolization procedure helps reduce body weight

Transarterial embolization procedure helps reduce body weight

A new study reports that individuals who underwent embolization of the left gastric artery for gastrointestinal bleeding experienced a 7.9 percent decrease in body weight three months after the procedure. Results of the study, which offer a potential new avenue for obesity research, will be presented next week at the annual meeting of the Radiological Society of North America. [More]
Helsinn grants exclusive commercialization rights to Chugai Pharma Marketing for anamorelin drug

Helsinn grants exclusive commercialization rights to Chugai Pharma Marketing for anamorelin drug

Swiss-based Helsinn group has granted Chugai Pharma Marketing Ltd., a wholly-owned subsidiary of Chugai Pharmaceutical Co., Ltd., exclusive commercialization rights to their innovative ghrelin receptor agonist, anamorelin, for the three major European pharma markets. [More]
Diets and the famine reaction: an interview with Associate Professor Amanda Salis, University of Sydney

Diets and the famine reaction: an interview with Associate Professor Amanda Salis, University of Sydney

The statistic that you often hear is that 95% of diets fail, but in actual fact, emerging research is now showing that it’s around 70% of diets that fail. That means that around 30% of people who are losing weight are actually keeping it off. So we’re doing better now than we were doing in the past, but there’s still work to be done. [More]
Aeterna Zentaris submits macimorelin acetate NDA to FDA

Aeterna Zentaris submits macimorelin acetate NDA to FDA

Aeterna Zentaris Inc. today announced that it has submitted a New Drug Application to the U.S. Food and Drug Administration ("FDA") for its ghrelin agonist, macimorelin acetate (AEZS-130). [More]
Researchers highlight presence of specific antibodies that regulate appetite in obese patients

Researchers highlight presence of specific antibodies that regulate appetite in obese patients

Obesity affects more than 15% of adults in France, and its constitutive mechanisms are still not completely explained. Normally, fine control of weight and food intake is coordinated by a specialised part of the brain (the hypothalamus). [More]
Ghrelin hormone released during chronic stress may predispose people to PTSD

Ghrelin hormone released during chronic stress may predispose people to PTSD

​About a dozen years ago, scientists discovered that a hormone called ghrelin enhances appetite. Dubbed the "hunger hormone," ghrelin was quickly targeted by drug companies seeking treatments for obesity - none of which have yet panned out. [More]

Rhythm starts RM-493 clinical trials in obesity patients with genetic deficiency

Rhythm announced today the initiation of the first of a series of clinical trials with RM-493, the company's novel melanocortin 4 receptor (MC4R) agonist, for the treatment of obesity in individuals with a genetic deficiency in the MC4R pathway. [More]

Rhythm Awarded $1.35M From Michael J. Fox Foundation

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MJFF awards $1.35M to Rhythm for Phase 2 clinical trial of RM-131 for Parkinson's disease

Rhythm announced today that The Michael J. Fox Foundation for Parkinson's Research has awarded a $1.35 million research grant to Rhythm to help fund a Phase 2 clinical trial of RM-131, the company's novel ghrelin agonist, for the treatment of refractory constipation in patients with Parkinson's disease. [More]

Sleep-deprived people may buy more high-calorie foods the following day

People who were deprived of one night’s sleep purchased more calories and grams of food in a mock supermarket on the following day in a new study published in the journal Obesity, the official journal of The Obesity Society. [More]

Study: People who are deprived of sleep purchase more food on following day

People who were deprived of one night's sleep purchased more calories and grams of food in a mock supermarket on the following day in a new study published in the journal Obesity, the official journal of The Obesity Society. [More]
Appetite-Controlling Hormone Leaves Obese People Still Hungry

Appetite-Controlling Hormone Leaves Obese People Still Hungry

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Glucagon loses its ability to help obese people, but continues to suppress hunger pangs

Glucagon, a hormone involved in regulating appetite, loses its ability to help obese people feel full after a meal, but it continues to suppress hunger pangs in people with type 1 diabetes, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). [More]
Health benefits of sufficient sleep: an interview with Dr Monique Verschuren, National Institute for Public Health and the Environment, the Netherlands

Health benefits of sufficient sleep: an interview with Dr Monique Verschuren, National Institute for Public Health and the Environment, the Netherlands

We used 6 hours or less per 24 hours as the definition of insufficient sleep, with 7 hours or more as sufficient sleep. In general, this is considered the amount of sleep that is sufficient for adults, although there can be differences between persons with respect to the amount of sleep needed. [More]

High-calorie breakfast protects against diabetes, hypertension and cardiovascular problems

Whether you hope to lose weight or just stay healthy, what you eat is a crucial factor. The right nutrients can not only trim your waistline, but also provide energy, improve your mood, and stave off disease. Now a Tel Aviv University researcher has found that it's not just what you eat - but when. [More]