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Ghrelin is a hormone produced mainly by P/D1 cells lining the fundus of the human stomach and epsilon cells of the pancreas that stimulates appetite. Ghrelin levels increase before meals and decrease after meals. It is considered the counterpart of the hormone leptin, produced by adipose tissue, which induces satiation when present at higher levels. Ghrelin is also produced in the hypothalamic arcuate nucleus where it stimulates the secretion of growth hormone from the anterior pituitary gland.

Aeterna Zentaris reports consolidated revenues of $8.6 million for third quarter 2009

11. November 2009 07:39
AEterna Zentaris Inc., a global biopharmaceutical company focused on endocrinology and oncology, today reported financial and operating results as at and for the three-month and nine-month periods ended September 30, 2009. [More]

Phase 3 clinical trial of macimorelin (AEZS-130) to be completed by AEterna Zentaris

19. October 2009 08:12
AEterna Zentaris Inc., a global biopharmaceutical company focused on endocrine therapy and oncology, today announced that it has initiated activities intended to complete the clinical development of the growth hormone secretagogue (GHS) / ghrelin agonist compound macimorelin (AEZS-130) which could be the first oral diagnostic test approved for growth hormone deficiency (GHD). Macimorelin is the International Non-proprietary Name (INN) designated for the compound by the World Health Organization (WHO). [More]

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Stomach hormone ghrelin may lead to new treatments for alcohol dependence

30. June 2009 03:37
Researchers at the Sahlgrenska Academy, Gothenburg, have discovered a new brain mechanism involved in alcohol addiction involving the stomach hormone ghrelin. When ghrelin’s actions in the brain are blocked, alcohol’s effects on the reward system are reduced. It is an important discovery that could lead to new therapies for addictions such as alcohol dependence. [More]

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Appetite-stimulating hormone may protect muscle from atrophy

13. June 2009 20:50
Researchers have found a potential new treatment for the common problem of muscle atrophy. Results of the animal study were presented at The Endocrine Society's 91st Annual Meeting in Washington, D.C. [More]

Exercise suppresses appetite by affecting appetite hormones

12. December 2008 12:21
A vigorous 60-minute workout on a treadmill affects the release of two key appetite hormones, ghrelin and peptide YY, while 90 minutes of weight lifting affects the level of only ghrelin, according to a new study. [More]

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Investigational drug, MK-677 shows promise for reducing age-related frailty

5. November 2008 07:40
Researchers at the University of Virginia Health System report that a daily single oral dose of an investigational drug, MK-677, increased muscle mass in the arms and legs of healthy older adults without serious side effects, suggesting that it may prove safe and effective in reducing age-related frailty. [More]

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Anti-frailty pill for seniors in the pipeline

5. November 2008 01:59
An 'anti-frailty' pill for seniors could be in the pipeline - the pill which increases muscle mass in arms and legs of older adults is the brainchild of researchers at the University of Virginia Health System. [More]

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Scientists discover a catalytic antibody that degrades a known appetite stimulant

28. October 2008 01:20
The antibody works against the gastric hormone ghrelin (pronounced "grell-in"), which has been linked to weight gain and fat storage through its metabolic actions. These findings point towards a potentially novel treatment for obesity that would interfere directly with the some of the biological mechanisms determining weight. [More]

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People with severe obstructive sleep apnea often have poor diets

15. October 2008 03:25
A study in the October 15 issue of the Journal of Clinical Sleep Medicine shows that unrelated to obesity, people with severe SDBs consume a more unhealthy diet, which may be a factor contributing to greater cardiovascular morbidity and mortality. These findings were most evident among women. [More]

Helicobacter pylori may help prevent adenocarcinoma, esophageal cancers

6. October 2008 16:29
Some bacteria may help protect against the development of a type of esophageal cancer, known as adenocarcinoma, according to a new review of the medical literature. These bacteria, which are called Helicobacter pylori, live in the stomachs of humans. [More]

Australian scientist finds the key to overeating as we age

21. August 2008 20:16
A Monash University scientist has discovered key appetite control cells in the human brain degenerate over time, causing increased hunger and potentially weight-gain as we grow older. [More]

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Research finds a role for the GABA neurotransmitter in maintaining energy balance

10. August 2008 21:05
Controlling body weight is a complicated process, as any frustrated dieter might attest. But as scientists continue to investigate the brain's intricate neurocircuitry and its role in maintaining energy balance, they are forming a clearer picture of the myriad events that lead to weight gain and weight loss. [More]

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Hunger hormone ghrelin increases during stress, may have antidepressant effect

24. June 2008 00:14
New research at UT Southwestern Medical Center may explain why some people who are stressed or depressed overeat. [More]

Blocked brain enzyme shows potential as target for appetite control, weight loss and blood sugar management

6. May 2008 20:04
Imagine being able to tone down appetite and promote weight loss, while improving the body's ability to handle blood sugar levels. [More]

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Gut hormone makes food appear more desirable

6. May 2008 19:56
A gut hormone that causes people to eat more does so by making food appear more desirable, suggests a new report in the May issue of Cell Metabolism, a publication of Cell Press. In a brain imaging study of individuals, the researchers found that reward centers respond more strongly to pictures of food in subjects who had received an infusion of the hormone known as ghrelin. [More]

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