Glucocorticoid is a compound that belongs to the family of compounds called corticosteroids (steroids). Glucocorticoids affect metabolism and have anti-inflammatory and immunosuppressive effects. They may be naturally produced (hormones) or synthetic (drugs).
Failure of hormone deprivation therapy, which is used to slow prostate cancer in patients, leads to castration-resistant prostate cancer, a lethal form of advanced disease with limited treatment options.
Born too soon, she weighed just over 1 pound at birth and spent the first three months of her life in the neonatal intensive care unit, fighting to live.
As is well-known, space flights bring with them a unique set of health hazards. That includes bone and muscle deterioration. Loss of bone density is currently one of the most serious problems for astronauts.
Tokyo Institute of Technology research: Gravitational biology: Real time imaging and transcriptome analysis of medaka aboard space station
The current method of treating prostate cancer involves identifying gene defects, which could help with the diagnosis of cancer and the development of individualised cancer treatments for patients.
Scientists have long known that chronic exposure to psychosocial stress early in life can lead to an increased vulnerability later in life to diseases linked to immune dysfunction and chronic inflammation, including arthritis, asthma, cancer, diabetes, heart disease and even mental illness.
A new study at the University of York has shown that a standard hormone supplement, used to boost energy levels in prostate cancer patients following radiotherapy, could potentially increase the chances of the cancer returning.
Due to the ageing of populations as well as increasing obesity and adverse lifestyle factors, type 2 diabetes (T2D) is reaching epidemic proportions in many parts of the world.
A team led by Wayne State University School of Medicine researcher Mark Greenwald, Ph.D., will use a four-year, $2,279,723 competitively renewed grant from the National Institute on Drug Abuse of the National Institutes of Health to explore whether the opioid addiction treatment medication buprenorphine can decrease the magnitude and/or duration of responses to stressors faced by recovering addicts.
The Endocrine Society today issued a Clinical Practice Guideline that recommends treating insufficient hormone levels in individuals with hypopituitarism by replacing hormones at levels as close to the body's natural patterns as possible.
A post-marketing safety study mandated by the U.S. Food and Drug Administration has shown that a combination drug therapy for the treatment of asthma is safe and effective.
A study published in the journal Scientific Reports from Nature publishing group, describes the mechanism by which caffeine counteracts age-related cognitive deficits in animals.
Scientists at the Research Institute of McGill University Health Centre have discovered a new genetic mutation linked to osteonecrosis of the hip, specifically the femoral head - the spherical-shaped mass at the top of the femur.
Traumatic experiences in childhood increase the risk of developing behavioral and psychiatric disorders later in life. It is also known that the consequences of a trauma can likewise be observed in the children of people affected even if those children have themselves not experienced any trauma.
A new study has helped to unveil the mystery of why chronic stress and depression can lead to bone loss and increase the risk of fractures.
Glucocorticoid (or steroid) therapy, prescribed to around half of patients with rheumatoid arthritis, is a known risk factor for developing diabetes. A study from The University of Manchester has found how the risk of diabetes increases in relation to the dosage, duration and timing of steroids.
Caltech biologists have performed the first large-scale screening in a vertebrate animal for genes that regulate sleep, and have identified a gene that when overactivated causes severe insomnia. Expression of the gene, neuromedin U (Nmu), also seems to serve as nature's stimulant--fish lacking the gene take longer to wake up in the morning and are less active during the day.
Simple physics may play a larger role than previously thought in helping control key bodily processes - such as how the body fights infection.
Pomalidomide (trade name: Imnovid) has been approved since 2013 for the treatment of multiple myeloma that has returned and is difficult to treat. The drug is an option for adults who have received two or more prior treatment regimens, including treatment with the drugs lenalidomide and bortezomib, and in whom the last treatment had no sufficient effect.
Two new studies by cancer scientists at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) suggest new approaches for treating cancer by inhibiting overactive cancer-promoting genes and by enhancing the activity of sluggish tumor-suppressor genes.