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Renaissance of "food as medicine" in modern clinical trials

Priya Venkatesan discusses in Nature Medicine how dietary interventions can prevent or delay diseases, highlighting the reemergence of "food as medicine" in modern clinical trials.

17 Apr 2024

Managing diabetes with probiotics and synbiotics

Systematic review in Clinical Nutrition analyzed randomized trials to assess the impact of prebiotics and synbiotics on glycemic control in diabetes, revealing significant benefits in fasting glucose, serum insulin, and HbA1C levels.

16 Apr 2024

Placental IGFBP1: A key factor in development of gestational diabetes

A new study led by the Harvard Pilgrim Health Care Institute has identified that a deficit in the placental expression of the gene insulin-like growth factor 1 (IGFBP1) and low IGFBP1 circulating levels are associated with insulin resistance during pregnancy, highlighting a potential risk factor for the development of gestational diabetes.

16 Apr 2024

Two decades of data confirm Mediterranean diet cuts hypertension risk

Over a 20-year study, adherence to the Mediterranean diet significantly reduced the incidence of hypertension among adults initially free from the condition, emphasizing the diet's long-term benefits in managing blood pressure.

15 Apr 2024

Soft tumor environments prime cancer cells for survival during metastasis

Researchers have discovered how the mechanical properties of tumors can prime cancer cells to better survive their spread to other organs.

13 Apr 2024

Are we eating what's really good for us? New insights into macronutrients and chronic disease

Review explores the impact of macronutrients like carbohydrates, proteins, and fats on health, emphasizing the need for precision in dietary guidance to manage and prevent chronic diseases effectively.

11 Apr 2024

Study reveals key gut microbiome differences in prediabetic patients

Study explores the differences in gut microbiome composition between prediabetic patients and healthy individuals, revealing significant variations that correlate with altered metabolic functions and potential diabetes progression.

11 Apr 2024

Exploring the health secrets of cucurbits: A closer look at Cucumis and Momordica

Review investigates the health impacts of Cucumis and Momordica plants, emphasizing their potential in managing diabetes, inflammation, and cancer due to their rich bioactive compounds.

11 Apr 2024

Gut bacteria play a pivotal role in obesity's impact on body fat metabolism

Review explores the complex interplay between gut microbiota dysregulation in obesity and its impacts on white and brown adipose tissue metabolism, focusing on direct and indirect effects on mitochondria, highlighting potential avenues for obesity treatment through microbiota-focused strategies.

11 Apr 2024

Study shows daily glucose levels fluctuate more than we thought, challenging diabetes diagnosis

Study reveals significant fasting glucose variability in nondiabetic adults using continuous glucose monitoring, challenging current diabetes diagnosis criteria and emphasizing the need for multiple measurements to reduce misclassification.

11 Apr 2024

New sleep-enhancing nutraceutical blend falls short in clinical trial

Study investigates the impact of a unique nutraceutical blend, combining L-theanine with valerian, saffron, and lemon balm extracts, on improving sleep quality, finding no significant difference compared to a placebo in individuals experiencing poor sleep.

10 Apr 2024

Meat or not to meat? Study challenges health claims of plant-based substitutes

Study finds no significant cardiometabolic health benefits of plant-based meat analog diets compared to animal-based meat diets among Singaporeans at risk of type 2 diabetes, challenging assumptions about plant-based meat substitutes' health advantages.

9 Apr 2024

CMS121 holds promise for treating metabolic diseases

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 6, entitled, "CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction."

9 Apr 2024

Study links glucose time series complexity to diabetes progression

Weiping Jia et al., at Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, China, conducted a study to explore the relationship between the complexity of glucose time series, as derived from continuous glucose monitoring (CGM), and the deterioration of glucose regulation.

9 Apr 2024

Childhood sedentariness associated with increase in blood insulin concentration, study shows

An increase in sedentary time from childhood is associated with a significant increase in blood insulin concentration, a new study shows.

9 Apr 2024

The complex relationship between obesity and male reproductive function

Authors have analyzed current evidence on the impact of obesity on the male reproduction system.

9 Apr 2024

SGLT2 inhibitors: A game-changer in preventing heart failure and sudden cardiac deaths

study reveals that SGLT2 inhibitors consistently lower the risk of major adverse cardiovascular events by 9% across various patient groups, especially impacting cardiovascular death reduction, highlighting their broad therapeutic potential beyond diabetes management.

9 Apr 2024

Ninerafaxstat shows good tolerability and safety in nonobstructive HCM patients

The investigational drug ninerafaxstat showed a good tolerability and safety profile, along with evidence of improvements in symptoms and exercise capacity among people with nonobstructive hypertrophic cardiomyopathy (HCM), according to results of a 12-week phase 2 trial presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Treating early-stage heart failure in diabetic patients: Insights from ARISE-HF trial

One of the first studies to attempt to treat early-stage heart failure in patients with Type 2 diabetes did not meet its primary endpoint, but a preplanned subgroup analysis found a statistically significant effect of treatment in patients who were not taking SGLT2 inhibitors or GLP-1 RAs, which are antidiabetic medications that also have benefits for the heart.

8 Apr 2024

Study: Empagliflozin shows mixed results in heart attack patients

Use of the sodium glucose cotransporter-2 (SGLT-2) inhibitor empagliflozin following a heart attack did not show a significant benefit in reducing overall heart failure hospitalizations or death from any cause, according to a study presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024