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Study explores sex-specific effects in Alzheimers disease pathology

The role of biological sex in the development and progression of Alzheimer's Disease (AD).

19 Oct 2023

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Research describes the development of a synthetic delivery vector called STxB for mucosal vaccination. It induces mucosal immunity, including resident memory CD8+ T cells and IgA antibodies, against antigens derived from mucosal viruses when administered intranasally in mice.

21 May 2023

A fast, highly sensitive, point-of-care RT-LAMP and CRISPR/Cas12a assay for the detection of SARS-CoV-2

Researchers used isothermal amplification with CRISPR-Cas12a to detect SARS-CoV-2.

30 Jun 2022

RT-LAMP assay shows promise as point-of-care SARS-CoV-2 detection assay across multiple settings

Researchers evaluate the feasibility and robustness of an optimized RT-LAMP SARS-CoV-2 detection assay across multiple resource-restricted settings.

4 Mar 2022

Study explores whether gut bacteria profiles differ by race and insulin sensitivity status

In the present study published in PLOS ONE, researchers designed and undertook a unique study to investigate these interactions further.

21 Jan 2022

Novel strategy to produce SARS-CoV-2 nucleocapsid protein for serological testing

New research discusses an alternative method of purifying the SARS-CoV-2 N protein using only metal exchange chromatography and denaturing conditions.

18 Nov 2021

Study reveals molecular machinery that regulates membrane association of Arf proteins

The small GTPases of the ADP-ribosylation factor (Arf) family are key initiators of various physiological processes including secretion, endocytosis, phagocytosis, and signal transduction. Arf family proteins function to mediate the recruitment of cytosolic effectors to specific subcellular compartments.

7 Jan 2021

Dextran sulphate-induced tau assemblies cause tau propagation in non-transgenic mice

Accumulation of assembled tau protein in the central nervous system is characteristic of Alzheimer's disease and several other neurodegenerative diseases, called tauopathies.

23 Sep 2020

Diagnosis of COVID-19 by RT-LAMP assay in 25 minutes

Even as COVID-19 continues its inexorable march, taking hundreds of thousands of lives and causing nearly 11 million cases, the diagnosis of the infection is still not sensitive or specific enough. Now, a new study by scientists at the Francis Crick Institute and published on the preprint server medRxiv...

3 Jul 2020

Nasal swab tests miss low viral SARS-CoV-2

A recent study by researchers from Beth Israel Deaconess Medical Center and Harvard Medical School, currently available on the preprint server medRxiv, demonstrates how nasal swab samples reliably detect patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that present with high viral loads, but may miss many patients with lower viral loads – questioning their role as a sole specimen for diagnostic purposes.

15 Jun 2020

New route for total synthesis of tetrodotoxin

In Japan, puffer fish is considered a delicacy, but the tickle to the taste buds comes with a tickle to the nerves: fugu contains tetrodotoxin, a strong nerve toxin.

6 Mar 2020

Researchers solve crystal structure for enzyme that plays key role in DNA methylation

A research team led by a biochemist at the University of California, Riverside has solved the crystal structure for an enzyme that plays a key role in DNA methylation, the process by which methyl groups are added to the DNA molecule.

7 Feb 2018

Scientists invent new way of folding and protecting recombinant proteins

A team from the NUS Yong Loo Lin School of Medicine has invented a fundamentally new way of folding and protecting recombinant proteins.

13 Nov 2017

‘Green’ disinfectant shows promise against hospital-acquired infections

Research shows that the polyhexamethylene-guanidine hydrochloride-based disinfectant Akwaton effectively destroys Bacillus subtilis spores even at low concentrations.

8 Aug 2012

New combination therapy can help improve cure rates for neuroblastoma

An experimental treatment that combines intense chemotherapy with a radioactive isotope linked to synthesized neurotransmitter is being tested in newly diagnosed cases of high-risk neuroblastoma - a deadly, hard-to-cure childhood cancer.

13 Jun 2012

NUS, NTU students win WFF's Ph.D. Prizes for environmental research

Antibiotics, which are among the world's most widely prescribed medicines, can easily find their way into rivers and lakes because they tend not to be removed through the normal sewage process.

8 Jul 2011

Carnosine may help prevent, treat cataracts

Researchers are reporting evidence from tissue culture experiments that the popular dietary supplement carnosine may help to prevent and treat cataracts, a clouding of the lens of the eye that is a leading cause of vision loss worldwide.

15 Jul 2009

Scientists evolve new proteins from scratch

Nature, through the trial and error of evolution, has discovered a vast diversity of life from what can only presumed to have been a primordial pool of building blocks.

24 May 2007

Study shows how the plague bacteria Yersinia pestis causes disease

The bacteria responsible for the plague and some forms of food poisoning "paralyze" the immune system of their hosts in an unexpected way, according to a new study in the September 8, 2006 issue of the journal Cell.

7 Sep 2006

Researchers have successfully targeted an HIV protein that has eluded existing therapies

Researchers targeted Nef, a protein responsible for accelerating the development of acquired immunodeficiency syndrome, or AIDS. Nef was targeted with small molecules synthesized by the researchers – molecules that disrupted Nef’s interaction with other proteins.

26 Sep 2004