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Heart failure (HF) is a condition in which a problem with the structure or function of the heart impairs its ability to supply sufficient blood flow to meet the body's needs. It should not be confused with cardiac arrest or myocardial infarction.
Researchers examine impact of extreme temperatures on number of deaths

Researchers examine impact of extreme temperatures on number of deaths

When temperatures are extremely high or low, there is a significant increase in the number of deaths caused by heart failure or stroke. [More]
Cardioxyl reports positive results from CXL-1427 Phase I trial for treatment of ADHF

Cardioxyl reports positive results from CXL-1427 Phase I trial for treatment of ADHF

Cardioxyl Pharmaceuticals, Inc. announced today the positive results of a clinical trial demonstrating that CXL-1427, a novel potential treatment for acute decompensated heart failure (ADHF), was well tolerated in healthy volunteers. [More]
Neuregulin 1 effective in promoting peripheral nerve regrowth

Neuregulin 1 effective in promoting peripheral nerve regrowth

Neuregulin 1 (NRG1) is a pleiotropic factor characterized by the existence of numerous isoforms arising from alternative splicing of exons that confer to the protein deeply different characteristics. [More]
Albuminuria change is a strong cardiovascular risk indicator in diabetes

Albuminuria change is a strong cardiovascular risk indicator in diabetes

Changes in albuminuria predict cardiovascular mortality and morbidity over and above glucose levels and blood pressure, say researchers. [More]
Phase 3 trial: NEXAVAR tablets fail to meet primary endpoint in HER2-negative breast cancer patients

Phase 3 trial: NEXAVAR tablets fail to meet primary endpoint in HER2-negative breast cancer patients

Bayer HealthCare and Onyx Pharmaceuticals Inc., an Amgen subsidiary, today announced that an investigational Phase 3 trial of NEXAVAR (sorafenib) tablets in patients with advanced breast cancer did not meet its primary endpoint of improving progression-free survival (PFS). [More]
Researchers receive inaugural funding from AHA to prevent heart disease and stroke

Researchers receive inaugural funding from AHA to prevent heart disease and stroke

Researchers and clinicians at UT Southwestern Medical Center are among a small, select group at U.S. universities to receive inaugural funding from the American Heart Association (AHA) for work that takes aim at heart disease and stroke. [More]
University of Leicester receives funding from two Masonic charities for heart study

University of Leicester receives funding from two Masonic charities for heart study

A University of Leicester research project has received vital philanthropic funding for the second year from two Masonic charities. [More]
Right kind of fat keeps the heart healthy

Right kind of fat keeps the heart healthy

Too much dietary fat is bad for the heart, but the right kind of fat keeps the heart healthy, according to a paper published in The Journal of Experimental Medicine. [More]
Expert guidance offers recommendations for hand hygiene in healthcare facilities

Expert guidance offers recommendations for hand hygiene in healthcare facilities

Expert guidance released today offers updated evidence reviews and recommendations for hand hygiene in healthcare facilities. [More]
Expert guidance helps prioritize strategies to prevent VAP

Expert guidance helps prioritize strategies to prevent VAP

Thousands of critically ill patients on life support develop ventilator-associated pneumonia (VAP) each year. A new document released today by a consortium of professional organizations helps prioritize strategies to prevent this potentially fatal infection. [More]
Potassium supplements with loop diuretics increase survival rates of heart failure patients

Potassium supplements with loop diuretics increase survival rates of heart failure patients

Researchers from the Perelman School of Medicine at the University of Pennsylvania found that patients taking prescription potassium supplements together with loop diuretics for heart failure have better survival rates than patients taking diuretics without the potassium. Moreover, the degree of benefit increases with higher diuretic doses. [More]
Freedom portable driver receives FDA approval for use with SynCardia Total Artificial Heart

Freedom portable driver receives FDA approval for use with SynCardia Total Artificial Heart

The Freedom portable driver received FDA approval on June 26, 2014 for use with the SynCardia temporary Total Artificial Heart as a bridge to transplantation in cardiac transplant candidates who are clinically stable. [More]
PAH disease burden ‘significant’

PAH disease burden ‘significant’

Patients with newly diagnosed pulmonary arterial hypertension have a substantial burden of disease, with more than half hospitalised during the first 3 years post-diagnosis, research shows. [More]
Education boosts glycaemic control after diabetes diagnosis

Education boosts glycaemic control after diabetes diagnosis

Attending a brief diabetes education programme enhances the glycaemic control achieved by patients newly diagnosed, research suggests. [More]
Exeter scientists find health benefits in rotten egg gas

Exeter scientists find health benefits in rotten egg gas

It may smell of flatulence and have a reputation for being highly toxic, but when used in the right tiny dosage, hydrogen sulfide is now being being found to offer potential health benefits in a range of issues, from diabetes to stroke, heart attacks and dementia. A new compound (AP39), designed and made at the University of Exeter, could hold the key to future therapies, by targeting delivery of very small amounts of the substance to the right (or key) places inside cells. [More]
Mercy Memorial Hospital System signs LOI to join Promedica

Mercy Memorial Hospital System signs LOI to join Promedica

Mercy Memorial Hospital System signed a letter of intent to join ProMedica, a not-for-profit, multi-hospital system based in Toledo, Ohio. [More]
Doctors offer new minimally invasive system to treat patients with narrowed, failing aortic heart

Doctors offer new minimally invasive system to treat patients with narrowed, failing aortic heart

Doctors at the Orlando Health Heart Institute are offering a new minimally invasive system to treat patients with narrowed, failing aortic heart valves who are considered to be at high risk to undergo surgery. Orlando Health is the only hospital in Orlando currently offering the Medtronic CoreValve® System. [More]
FDA grants Breakthrough Therapy status to Novartis' CTL019 for treatment of relapsed/refractory ALL

FDA grants Breakthrough Therapy status to Novartis' CTL019 for treatment of relapsed/refractory ALL

Novartis announced today that the United States Food and Drug Administration has granted Breakthrough Therapy status to CTL019, an investigational chimeric antigen receptor (CAR) therapy for the treatment of pediatric and adult patients with relapsed/refractory acute lymphoblastic leukemia (r/r ALL). [More]
Standard risk factors stratify already high-risk diabetic patients

Standard risk factors stratify already high-risk diabetic patients

Cardiovascular disease risk factors are associated with mortality even among patients with Type 2 diabetes who are already at high risk due to having high coronary artery calcified plaque, say researchers. [More]
Insulin pumps better than injections for glycaemic control in Type 2 diabetes

Insulin pumps better than injections for glycaemic control in Type 2 diabetes

Patients with Type 2 diabetes achieve better glycaemic control with insulin pumps than multiple insulin injections, show the findings of the OpT2mise randomised trial. [More]