Homocysteine News and Research

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Vitamin B12, folic acid supplements could potentially halt or reverse advanced form of fatty liver disease

Scientists at Duke-NUS Medical School in Singapore have uncovered a mechanism that leads to an advanced form of fatty liver disease-;and it turns out that vitamin B12 and folic acid supplements could reverse this process.

5 Aug 2022

COVID-19 may affect a group of biochemical reactions called one-carbon metabolism

A new study addresses the relationship between SARS-CoV-2 to the metabolism of one-carbon molecules in the host, suggesting new therapeutic pathways.

13 Apr 2022

Omicron BA.1.1 and BA.2 subvariants with new mutations in New Zealand and Hong Kong

A new study describes mutations found in the SARS-CoV-2 BA.1 variant in Hong Kong and New Zealand.

20 Mar 2022

Serum folate deficiency in older people may be associated with heightened dementia and death risks

Low levels of folate (vitamin B9) in the blood may be linked to a heightened risk of dementia and death from any cause in older people, suggests research published online in the journal Evidence Based Mental Health.

16 Mar 2022

Study suggests folic acid supplementation linked to increased risk for COVID-19 diagnosis

In a recent study posted to the medRxiv* preprint server, researchers evaluated if folic acid or methotrexate use impacts the risk of coronavirus disease 2019 (COVID-19) diagnosis or associated mortality in the United Kingdom (UK).

15 Feb 2022

Novel AI-based system models the progression of chronic diseases as patients age

Using artificial intelligence, a team of University at Buffalo researchers has developed a novel system that models the progression of chronic diseases as patients age.

7 Dec 2021

Could 6′,6′-difluoro-aristeromycin (DFA) have broad-spectrum antiviral potential against coronaviruses?

Researchers at the Leiden University Medical Center demonstrated that low-micromolar concentrations of 6′,6′-difluoro24 aristeromycin (DFA), an adenosine nucleoside analog, strongly inhibits the replication of Middle East respiratory syndrome coronavirus (MERS-CoV) in a cell-based infection assay.

25 May 2021

Inhibition of nsp14 methyltransferase as a potential antiviral target for SARS-CoV-2

Beyond vaccination, the broad-spectrum antiviral medication remdesivir has robust clinical evidence and is known as the best antiviral treatment to reduce severe COVID-19 infection in hospitalized patients. Research led by John F.X. Diffley of the Chromosome Replication Laboratory suggests a potential therapeutic target for treatment development is the viral RNA cap methyltransferases, essential for viral protein translation and immune evasion.

13 Apr 2021

Screening for SARS-CoV-2 non-structural protein 14 inhibitors

In a paper recently uploaded to the preprint server bioRxiv* by Diffley et al. (April 8th, 2021), inhibitors of one essential SARS-CoV-2 non-structural protein are explored, with four compounds, in particular, identified as potential antiviral leads that exhibit synergistic effects with antiviral drug remdesivir.

12 Apr 2021

The role of RNA capping of SARS-CoV-2 in immunity evasion

The SARS-CoV-2 pathogen successfully uses multiple immune evasion mechanisms to achieve infection within its host. An intriguing new study describes one such process, which may help develop drugs to counteract the virus more effectively.

16 Mar 2021

Anticardiolipin antibodies and COVID-19

A new study has shown that anticardiolipin antibodies are associated with the novel coronavirus infection or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19.

10 Jun 2020

Russian Science Foundation funds eleven Kazan University projects

Eleven Kazan University projects receive funding from the Russian Science Foundation. The results were published on 1st April 2020.

2 Apr 2020

B-group vitamins may be beneficial for people with first episode psychosis

B-group vitamins may be beneficial for maintaining concentration skills among people experiencing a first episode of psychosis, a study by researchers from Orygen, the National Centre of Excellence in Youth Mental Health, has found.

16 Jan 2019

Essential nutrient may hold promise in the war against Alzheimer's disease

In a new study, researchers at the Biodesign Institute explore a safe and simple treatment for one of the most devastating and perplexing afflictions: Alzheimer's disease.

8 Jan 2019

Precision medicine-based approach to slow or reverse biologic drivers of Alzheimer's disease

Alzheimer's disease is a progressive, neurodegenerative condition in which individuals exhibit memory loss, dementia, and impaired metabolism.

14 Nov 2018

New study reveals the extent of brain damage due to elevated homocysteine

The amino acid homocysteine occurs naturally in the human body, generated as a byproduct of methionine metabolism.

17 May 2018

Older Americans are hooked on vitamins despite scarce evidence they work

When she was a young physician, Dr. Martha Gulati noticed that many of her mentors were prescribing vitamin E and folic acid to patients. Preliminary studies in the early 1990s had linked both supplements to a lower risk of heart disease.

4 Apr 2018

Ludwig study elucidates mechanism behind metabolic vulnerability of some breast tumors

Scientists have known since the 1980s that many cancer cells are relatively sensitive to the deprivation of an essential amino acid known as methionine. It has, however, long been unclear what causes such marked dependency on methionine.

20 Dec 2017

Scientists create new method to make peptide stapling widely available

UK scientists have created a new method to structure peptides, which they say will be cheaper and make the process of using stapled peptides in drug discovery much more widely available.

2 Jun 2017

Avocado consumption linked to higher intake of essential nutrients, better diet quality

A new analysis of the National Health and Nutrition Examination Survey data, compared avocado consumers to non-consumers and found that consuming avocados may be associated with an overall better diet, higher intake of essential nutrients, lower body weight, lower Body Mass Index and smaller waist circumference.

2 May 2017