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Insilico Medicine's AI-designed drug ISM3412 receives FDA IND approval

Clinical stage artificial intelligence (AI)-driven drug discovery company Insilico Medicine announces that it has received approval from the U.S. Food and Drug Administration for its Investigational New Drug application for ISM3412, a small molecule inhibitor of MAT2A for the potential treatment of MTAP deleted cancers designed with Insilico's generative AI platform.

25 Apr 2024

Protecting telomeres: ILF3 and the regulation of R-loop dynamics

Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres.

22 Apr 2024

New insights into the exacerbation of psoriasis through specific genetic defects

The inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model.

27 Mar 2024

Bioengineering edible mycelium to enhance nutritional value, color, and flavor

A modular synthetic biology toolkit for Aspergillus oryzae, an edible fungus used in fermented foods.

21 Mar 2024

Study identifies CDK9's involvement in DNA repair during cell division

Researchers describe a newly-observed role for the protein Cyclin Dependent Kinase 9 (CDK9) in regulating DNA repair during cellular division, where errors can become the origin of cancerous tumor growth.

14 Mar 2024

Unveiling the molecular mechanism responsible for crossover interference during meiosis

Movies such as 'X-Men,' 'Fantastic Four,' and 'The Guardians,' which showcase vibrant mutant heroes, have captivated global audiences.

7 Mar 2024

Combo of targeted and immunotherapy may boost NSCLC treatment by overcoming immune resistance and enhancing anti-tumor activity

Researchers evaluated rational combination treatment regimens for advanced/metastatic non-small-cell lung cancer (NSCLC).

15 Feb 2024

Combination therapy offers breakthrough in NSCLC treatment

A specific combination of targeted therapy and immunotherapy may better help patients with non-small cell lung cancer (NSCLC) overcome inherent immune resistance and reinvigorate anti-tumor activity, according to a new study led by a researcher from The University of Texas MD Anderson Cancer Center.

13 Feb 2024

SARS-CoV-2 fragments found to mimic immune system peptides, fueling inflammation

Study reveals SARS-CoV-2 fragments mimic immune peptides, potentially driving the virus's inflammatory response, offering insights into COVID-19's severe inflammation mechanisms.

5 Feb 2024

Immune protein Ku70 key in fighting bowel cancer

Study establishes Ku70's role in tumor suppression, showing that reduced expression or mutations in this DNA repair protein significantly increase intestinal cancer risk.

30 Jan 2024

Gene variant linked to increased miscarriage risk through disrupted chromosome pairing

Scientists at deCODE genetics, a subsidiary of Amgen and their collaborators from Iceland, Denmark and USA published a study today in Nature Structural and Molecular Biology titled "Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effects on recombination".

29 Jan 2024

RecA protein skips "unwinding" step in DNA repair

Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by incorporating a dangling single-strand end into intact double strands, and repairing the break based on the undamaged sequence.

20 Jan 2024

Insilico Medicine leverages AI to identify promising new target for breast and gynecological cancers

Insilico Medicine("Insilico"), a clinical stage generative artificial intelligence (AI)-driven drug discovery company, recently published an early research that it has identified MYT1 as a promising new therapeutic target for breast and gynecological cancer, and discovered a series of novel, potent, and highly selective inhibitors specifically targeting MYT1.

19 Jan 2024

Combining health data with whole genome sequence data in cancer patients can help doctors provide more tailored care

Researchers evaluated the impact of integrating whole-genome sequencing data with clinical outcomes across 13,880 tumors from 33 cancer types, assessing precision care potentials within the UK NHS through the 100,000 Genomes Cancer Programme.

16 Jan 2024

mRNA COVID-19 vaccines highly effective in preventing hospitalizations among adolescents in Nordic study

Study evaluated the effectiveness of mRNA COVID-19 vaccines (BNT162b2, mRNA-1273, and heterologous schedules) in preventing hospitalization among adolescents in Nordic countries, finding high protection rates of 73% to 86% at six months.

14 Jan 2024

Study uncovers new weapon against PARP inhibitor-resistant ovarian cancers

A new editorial paper was published in Oncotarget's Volume 14 on December 22, 2023, entitled, "One more step toward treatment of PARP inhibitor-resistant ovarian cancers."

10 Jan 2024

Gut enzyme discovery sheds light on bilirubin balance in humans

Researchers study identified BilR, a gut microbiota-derived enzyme, crucial for converting bilirubin to urobilinogen, impacting bilirubin homeostasis in humans.

7 Jan 2024

New method illuminates intricate interactions of the synaptonemal complex in nematodes

We have two copies of each chromosome in every cell in our bodies except in our reproductive cells. Sperm and egg cells contain a single copy of each chromosome with a unique mix of genes from our parents, an evolutionary trick to give our offspring genetic variability.

3 Jan 2024

Evaluation of immunogenicity-induced DNA vaccines against different SARS-CoV-2 variants

Five DNA vaccine candidates based on different SARS-CoV-2 strains.

12 Dec 2023

Novel mRNA vaccine GLB-COV2-043 shows high efficacy against COVID-19 variants in early trials

The safety, efficacy, and immunogenicity of a mRNA-based vaccine.

5 Dec 2023