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Specific high-fat diets linked to increased tumor formation in mouse model of intestinal cancer

Specific high-fat diets linked to increased tumor formation in mouse model of intestinal cancer

A high-fat-diet-induced immune reaction causes inflammation leading to intestinal cancer in a mouse model - even among animals that are not obese -- according to a new study from the Perelman School of Medicine at the University of Pennsylvania, Case Western Reserve University, the Pacific Northwest Research Institute, and others. [More]
Higher proportion of CKD patients receive renal replacement therapy in the U.S. than other countries

Higher proportion of CKD patients receive renal replacement therapy in the U.S. than other countries

A new study indicates that a much higher proportion of patients with advanced chronic kidney disease (CKD)—even those ≥85 years of age—receive renal replacement therapy (RRT) such as maintenance dialysis or kidney transplantation in the United States than in other developed countries. [More]
Novel immunotherapy shows promise against AML in clinical trial

Novel immunotherapy shows promise against AML in clinical trial

A new type of immunotherapy shows promise against cases of acute myeloid leukemia (AML) that recur after treatment or that never respond to therapy in the first place. [More]
Penn Center for Global Health honors Ernest Madu with inaugural Global Health Champion award

Penn Center for Global Health honors Ernest Madu with inaugural Global Health Champion award

The Center for Global Health in the Perelman School of Medicine at the University of Pennsylvania is pleased to honor Ernest Madu, MD, chairman and CEO of the Heart Institute of the Caribbean with its first annual Global Health Champion Award. [More]
Study finds one in nine people admitted to ERs for violent injuries end up with recurrent visits

Study finds one in nine people admitted to ERs for violent injuries end up with recurrent visits

Approximately one in nine people sent to Florida emergency rooms (ERs) for injuries caused by acts of intentional violence - including shootings, stabbings, assaults, etc. - in 2010 ended up being violently injured again within two years. [More]
Study finds late onset and short duration of pain relief treatment in many terminal cancer patients

Study finds late onset and short duration of pain relief treatment in many terminal cancer patients

Many terminal cancer patients are not getting adequate pain relief early enough, according to a University of Leeds study. [More]
Liquid biopsies may be effective option for detecting mutations in advanced lung cancer patients

Liquid biopsies may be effective option for detecting mutations in advanced lung cancer patients

For patients with advanced lung cancer, a non-invasive liquid biopsy may be a more effective and suitable alternative to the gold standard tissue biopsy to detect clinically relevant mutations and help guide their course of treatment, suggests a new study published this week in the journal Clinical Cancer Research from researchers at the Abramson Cancer Center at the University of Pennsylvania. [More]
Virginia Mason offers totally laparoscopic advanced surgery for removing tumors from pancreas

Virginia Mason offers totally laparoscopic advanced surgery for removing tumors from pancreas

Virginia Mason now offers the totally laparoscopic Whipple procedure as an advanced surgical option for removing tumors from the head of the pancreas. [More]
New mouse model helps identify potential drug target for hard-to-treat social aspects of ASD

New mouse model helps identify potential drug target for hard-to-treat social aspects of ASD

A study of a new mouse model identifies a drug target that has the potential to increase social interaction in individuals with some forms of autism spectrum disorder (ASD), according to researchers in the Perelman School of Medicine at the University of Pennsylvania. The team published their work in Biological Psychiatry. [More]
Study highlights how warning labels on sugary drinks influence purchasing intentions of teenagers

Study highlights how warning labels on sugary drinks influence purchasing intentions of teenagers

Teens are more than 15 percent less likely to say they would purchase soft drinks and other sugary drinks that include health warning labels, according to a new study led by researchers at the Center for Health Incentives and Behavioral Economics in the Perelman School of Medicine at the University of Pennsylvania. [More]
Delirium in advanced cancer patients: an interview with Dr Knox Todd

Delirium in advanced cancer patients: an interview with Dr Knox Todd

Delirium is a terribly distressing syndrome of acute confusion. We often see it in the emergency department in older patients and in those with multiple medical problems. They may be acting strangely at home and concerned loved ones bring them to the emergency department. [More]
New study explores why cost of dying higher for African Americans and Hispanics

New study explores why cost of dying higher for African Americans and Hispanics

Dying in America is an expensive process, with about one in four Medicare dollars going to care for people in their last year of life. But for African Americans and Hispanics, the cost of dying is far higher than it is for whites. [More]
New biomaterial allows scientists to study how stem cells sense stiffness of surrounding environment

New biomaterial allows scientists to study how stem cells sense stiffness of surrounding environment

A new biomaterial can be used to study how and when stem cells sense the mechanics of their surrounding environment, found a team led by Robert Mauck, PhD, the Mary Black Ralston Professor for Education and Research in Orthopaedic Surgery, in the Perelman School of Medicine at the University of Pennsylvania. [More]
Non-coding RNAs play key role in maintaining proper balance between fighting infection and inflammation

Non-coding RNAs play key role in maintaining proper balance between fighting infection and inflammation

Special RNA molecules called long non-coding RNAs (lncRNAs) are key controllers for maintaining immune health when fighting infection or preventing inflammatory disorders, according to research led by Jorge Henao-Mejia, MD, PhD, an assistant professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania. [More]
Acupuncture may be viable option to manage pain in children with complex medical conditions

Acupuncture may be viable option to manage pain in children with complex medical conditions

It appears that acupuncture may be a viable option for pain management when it comes to pediatric patients who have complex medical conditions, according to new research published by Gillette Children's Specialty Healthcare in St. Paul, Minnesota. [More]
Penn study sheds light on role of essential compound in maintaining optimal muscle function

Penn study sheds light on role of essential compound in maintaining optimal muscle function

Maintaining proper levels of an essential helper molecule is crucial for optimal muscle function, according to a study led by Joseph Baur, PhD, an assistant professor of Physiology in the Perelman School of Medicine at the University of Pennsylvania. [More]
Researchers uncover how GWAS-implicated gene affects HDL-cholesterol levels

Researchers uncover how GWAS-implicated gene affects HDL-cholesterol levels

Researchers have uncovered how genes identified from genome-wide association studies (GWAS) affect high-density lipoprotein cholesterol (HDL-C), a biomarker of cardiovascular disease, after comparing several animal models with human patient data. [More]
Penn study shows synchronized refill program enhances medication adherence

Penn study shows synchronized refill program enhances medication adherence

Programs aimed at helping patients adhere to prescription medication regimens have become an area of interest for researchers as nearly half of patients do not take medications as prescribed. [More]
Metabolic-checkpoint inhibitor combination approach may improve cancer therapies

Metabolic-checkpoint inhibitor combination approach may improve cancer therapies

Reprogramming of the molecular pathways underlying normal metabolism is essential for T cell infection-fighting function and for the immune system to form a "memory" of the microbes it has already encountered. But exactly how metabolism in exhausted T cells is maintained in chronic infections and cancer is a missing element in this line of research. [More]
Penn's ADCC receives $8.8 million grant to continue research on treatment for AD and related dementias

Penn's ADCC receives $8.8 million grant to continue research on treatment for AD and related dementias

The University of Pennsylvania's Alzheimer's Disease Core Center has been awarded an estimated $8.8 million over five years from the National Institute on Aging to continue its mission of investigating mechanisms, diagnostics, treatments and strategies for Alzheimer's Disease (AD) and related dementias including Parkinson's disease (PD), Parkinson's disease dementia (PDD), Lewy Body dementia (LBD) and frontotemporal lobar degeneration (FTLD). [More]
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